Near‐Infrared‐Triggered Azobenzene‐Liposome/Upconversion Nanoparticle Hybrid Vesicles for Remotely Controlled Drug Delivery to Overcome Cancer Multidrug Resistance

Abstract

Overcoming multidrug resistance is achieved by developing a novel drugdelivery-system paradigm based on azobenzene liposome and phosphatidylcholine-modified upconversion nanoparticle (UCNP) hybrid vesicles for controlled drug release using a nearinfrared (NIR) laser. Upon 980 nm light irradiation, the reversible photoisomerization of the azobenzene derivatives by simultaneous UV and visible light emitted from the UCNPs makes it possible to realize NIR-triggered release of the chemotherapeutic drug doxorubicin.

Self‐Amplified Photodynamic Therapy through the 1O2‐Mediated Internalization of Photosensitizers from a Ppa‐Bearing Block Copolymer

“…[1] Though PDT has been apromising option for cancer treatment owing to its non-invasiveness,t he photosensitizer still faces many barriers,s uch as poor water-solubility,non-selectivity,and poor biocompatibility,restricting the use of PDT in clinical practice. [2] To overcome these limitations,n anocarriers [2] such as polymer nanoparticles, [3] liposomes, [4] dendrimers, [5] and inorganic nanoparticles [6] or other kind nanoparticles, [7] have been developed for the delivery of these hydrophobic drugs to prolong blood circulation and enhance the accumulation of drugs in tumor tissues by the enhanced permeation and retention (EPR) effect. [8] Thedelivery efficiencyofhydrophobic drugs,such as photosensitizers,i se nhanced by the nanocarriers,b ut many limitations still exist, such as premature leakage and nonselective release of photosensitizers.…”

Near‐Infrared Triggered Decomposition of Nanocapsules with High Tumor Accumulation and Stimuli Responsive Fast Elimination

“…[21] As ap romising candidate,near-infrared (NIR) light would bring new opportunities owing to minimal absorbance and maximum penetration of tissues. [22][23][24] Thep olymer nanocapsules,i nw hich polymers can act as a"cage" and encapsulate small functional nanoparticles or drugs.However,unlike condensed materials, polymers are more likely to deform and reshape. [25][26][27] Thus they are often chosen as building blocks of stimuli responsive systems.…”

Near‐Infrared Photoinduced Reactions Assisted by Upconverting Nanoparticles

“…UCNPs can be incorporated not only into micelles but also vesicles (Figure b) . Zhang and co‐workers introduced UCNPs and the anticancer drug doxorubicin into vesicles formed from an amphiphilic azobenzene derivative . Upon 980 nm light irradiation, the photoisomerization of the azobenzene derivatives triggered by the upconverted light induced release of doxorubicin.…”

“…[21] UCNPs can be incorporated not only into micelles but also vesicles (Figure 6b). [22] Zhang and co-workersi ntroduced…”