Near infrared spectroscopy to study the brain: an overview

Wolf, Martin; Morren, Geert; Haensse, Daniel; Karen, Tanja; Wolf, Ursula; Fauchère, Jean‐Claude; Bucher, H. U.

doi:10.2478/s11772-008-0042-z

Cited by 31 publications

(24 citation statements)

References 83 publications

(101 reference statements)

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“…On the other hand, in adults values for changes in light intensity range from 0.01% to 0.00001%. 29 The effect found here is about 63 times larger than the lower boundary of this given range for adults (assumption is DPF ¼ 4.714 and distance 1.25 cm). The increased effectiveness of NIRS in newborns is also shown in simulations.…”

Section: Optical Neuronal Signalmentioning

confidence: 88%

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Multimodal recording of brain activity in term newborns during photic stimulation by near-infrared spectroscopy and electroencephalography

et al. 2012

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In this study 14 healthy term newborns (postnatal mean age 2.1 days) underwent photic stimulation during sleep on two different days. Near-infrared spectroscopy (NIRS) and electroencephalography (EEG) was acquired simultaneously. The aims of the study were: to determine (i) the sensitivity and (ii) the repeatability of NIRS to detect the hemodynamic response, (iii) the sensitivity and (iv) the repeatability of EEG to detect a visual evoked potential (VEP), (v) to analyze optical data for the optical neuronal signal, and (vi) to test whether inadequate stimulation could be reason for absent hemodynamic responses. The results of the study were as follows. (i) Sensitivity of NIRS was 61.5% to detect hemodynamic responses; (ii) their reproducibility was 41.7%. A VEP was detected (iii) in 96.3% of all subjects with (iv) a reproducibility of 92.3%. (v) In two measurements data met the criteria for an optical neuronal signal. The noise level was 9.6·10-5% change in optical density. (vi) Insufficient stimulation was excluded as reason for absent hemodynamic responses. We conclude that NIRS is an promising tool to study cognitive activation and development of the brain. For clinical application, however, the sensitivity and reproducibility on an individual level needs to be improved. Abstract. In this study 14 healthy term newborns (postnatal mean age 2.1 days) underwent photic stimulation during sleep on two different days. Near-infrared spectroscopy (NIRS) and electroencephalography (EEG) was acquired simultaneously. The aims of the study were: to determine (i) the sensitivity and (ii) the repeatability of NIRS to detect the hemodynamic response, (iii) the sensitivity and (iv) the repeatability of EEG to detect a visual evoked potential (VEP), (v) to analyze optical data for the optical neuronal signal, and (vi) to test whether inadequate stimulation could be reason for absent hemodynamic responses. The results of the study were as follows. (i) Sensitivity of NIRS was 61.5% to detect hemodynamic responses; (ii) their reproducibility was 41.7%. A VEP was detected (iii) in 96.3% of all subjects with (iv) a reproducibility of 92.3%. (v) In two measurements data met the criteria for an optical neuronal signal. The noise level was 9.6 · 10 −5 % change in optical density. (vi) Insufficient stimulation was excluded as reason for absent hemodynamic responses. We conclude that NIRS is an promising tool to study cognitive activation and development of the brain. For clinical application, however, the sensitivity and reproducibility on an individual level needs to be improved.

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Section: Optical Neuronal Signalmentioning

confidence: 88%

“…This assumption holds true when changes in scattering are the source of intensity changes, as suggested in previous studies. 23,[27][28][29] Table 2 lists the results for each criterion and measurement. Two measurements met all criteria after application of PEMAPS (three without).…”

Section: Optical Neuronal Signalmentioning

confidence: 99%

Multimodal recording of brain activity in term newborns during photic stimulation by near-infrared spectroscopy and electroencephalography

et al. 2012

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“…Near infrared spectroscopy ͑NIRS͒ has been successfully applied in medicine for a variety of noninvasive diagnostic purposes, e.g., to quantitatively investigate the oxygenation, blood flow, volume, or function of tissues such as the breast, muscle, or brain. [1][2][3][4] Various techniques have been developed for this purpose. Continuous wave spectroscopy employs light sources with constant intensity to determine changes in attenuation.…”

Section: Introductionmentioning

confidence: 99%

Multifrequency frequency-domain spectrometer for tissue analysis

Spichtig

Hornung

Brown

et al. 2009

Review of Scientific Instruments

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In this paper we describe the modification and assessment of a standard multidistance frequencydomain near infrared spectroscopy (NIRS) instrument to perform multifrequency frequency-domain NIRS measurements. The first aim of these modifications was to develop an instrument that enables measurement of small volumes of tissue such as the cervix, which is too small to be measured using a multidistance approach. The second aim was to enhance the spectral resolution to be able to determine the absolute concentrations of oxy-, deoxy-and total hemoglobin, water, and lipids. The third aim was to determine the accuracy and error of measurement of this novel instrument in both in vitro and in vivo environments. The modifications include two frequency synthesizers with variable, freely adjustable frequency, broadband high-frequency amplifiers, the development of a novel avalanche photodiode (APD) detector and demodulation circuit, additional laser diodes with additional wavelengths, and a respective graphic user interface to analyze the measurements. To test the instrument and algorithm, phantoms with optical properties similar to those of biological tissue were measured and analyzed. The results show that the absorption coefficient can be determined with an error of <10%. The error of the scattering coefficient was <31%. Since the accuracy of the chromophore concentrations depends on the absorption coefficient and not on the scattering coefficient, the <10% error is the clinically relevant parameter. In addition, the new APD had similar accuracy as the standard photomultiplier tubes. To determine the accuracy of chromophore concentration measurements we employed liquid Intralipid® phantoms that contained 99% water, 1% lipid, and an increasing concentration of hemoglobin in steps of 0.010 mM. Water concentration was measured with an accuracy of 6.5% and hemoglobin concentration with an error of 0.0024 mM independent of the concentration. The measured lipid concentration was negative, which shows that the current setup is not suitable for measuring lipids. Measurements on the forearm confirmed reasonable values for water and hemoglobin concentrations, but again not for lipids. As an example of a future application, chromophore concentrations in the cervix were measured and comparable values to the forearm were found. In conclusion the modified instrument enables measurement of water concentration in addition to oxy-and deoxyhemoglobin concentrations with a single source-detector distance in small tissue samples. Future work will focus on resolving the lipid component. In this paper we describe the modification and assessment of a standard multidistance frequency-domain near infrared spectroscopy ͑NIRS͒ instrument to perform multifrequency frequency-domain NIRS measurements. The first aim of these modifications was to develop an instrument that enables measurement of small volumes of tissue such as the cervix, which is too small to be measured using a multidistance approach. The second aim was to enhance the spect...

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“…650-950 nm) into tissue and measuring the diffusely back-reflected light, near-infrared spectroscopy (NIRS) is able to determine concentration changes of oxy-and deoxyhemoglobin ([O2Hb], [HHb]), which are related to changes in tissue hemodynamics and oxygenation [1][2][3][4]. For example, brain activity has been assessed using NIRS in adults [3,[5][6][7][8][9][10][11], infants and neonates [12][13][14][15], or animals [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

A New Approach for Automatic Removal of Movement Artifacts in Near-Infrared Spectroscopy Time Series by Means of Acceleration Data

et al. 2015

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Near-infrared spectroscopy (NIRS) enables the non-invasive measurement of changes in hemodynamics and oxygenation in tissue. Changes in light-coupling due to movement of the subject can cause movement artifacts (MAs) in the recorded signals. Several methods have been developed so far that facilitate the detection and reduction of MAs in the data. However, due to fixed parameter values (e.g., global threshold) none of these methods are perfectly suitable for long-term (i.e., hours) recordings or were not time-effective when applied to large datasets. We aimed to overcome these limitations by automation, i.e., data adaptive thresholding specifically designed for long-term measurements, and by introducing a stable long-term signal reconstruction. Our new technique ("acceleration-based movement artifact reduction algorithm", AMARA) is based on combining two methods: the "movement artifact reduction algorithm" (MARA, et al. Phys. Meas. 2010, 31, 649-662), and the "accelerometer-based motion artifact removal" (ABAMAR, Virtanen et al. J. Biomed. Opt. 2011, 16, 087005). We describe AMARA in detail and report about successful validation of the algorithm using empirical NIRS data, measured over the prefrontal cortex in adolescents during sleep. In addition, we compared the performance of AMARA to that of MARA and ABAMAR based on validation data.OPEN ACCESS Algorithms 2015, 8 1053 Scholkmann

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Near infrared spectroscopy to study the brain: an overview

Abstract: This paper gives an overview of principles, technologies, and applications using near infrared spectrometry and imaging (NIRS and NIRI)

Cited by 31 publications

References 83 publications

Multimodal recording of brain activity in term newborns during photic stimulation by near-infrared spectroscopy and electroencephalography

Multimodal recording of brain activity in term newborns during photic stimulation by near-infrared spectroscopy and electroencephalography

Multifrequency frequency-domain spectrometer for tissue analysis

A New Approach for Automatic Removal of Movement Artifacts in Near-Infrared Spectroscopy Time Series by Means of Acceleration Data

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