Near-infrared spectroscopy to monitor cerebral oxygen saturation in single-ventricle physiology

Ricci, Marco; Lombardi, Pierluca; Schultz, Steven; Galindo, Alvaro; Coscarella, Ernesto; Vasquez, Amelia; Rosenkranz, Eliot R.

doi:10.1016/j.jtcvs.2005.07.039

Cited by 22 publications

(28 citation statements)

References 17 publications

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“…Others have tested the feasibility of NIRS to record changes in brain oxygenation induced by hypoxemia [15][16][17][18][34][35][36]. However, hypoxemia was induced by application of artificial gas-mixtures simulating high altitude hypoxia.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast to SpO 2 , rSO 2 depends mainly on venous blood [14]. In previous methodological studies a clear positive correlation between SpO 2 and rSO 2 has already been demonstrated [16][17][18]. This correlation was shown in experiments where the participants inhaled hypoxic gas mixtures consisting of reduced O 2 substituted with N 2 during normocapnia.…”

Section: Introductionmentioning

confidence: 97%

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Evaluation of near-infrared spectroscopy under apnea-dependent hypoxia in humans

Eichhorn

Erdfelder

Kessler

et al. 2015

J Clin Monit Comput

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In this study we investigated the responsiveness of near-infrared spectroscopy (NIRS) recordings measuring regional cerebral tissue oxygenation (rSO2) during hypoxia in apneic divers. The goal was to mimic dynamic hypoxia as present during cardiopulmonary resuscitation, laryngospasm, airway obstruction, or the "cannot ventilate cannot intubate" situation. Ten experienced apneic divers performed maximal breath hold maneuvers under dry conditions. SpO2 was measured by Masimo™ pulse oximetry on the forefinger of the left hand. NIRS was measured by NONIN Medical's EQUANOX™ on the forehead or above the musculus quadriceps femoris. Following apnea median cerebral rSO2 and SpO2 values decreased significantly from 71 to 54 and from 100 to 65%, respectively. As soon as cerebral rSO2 and SpO2 values decreased monotonically the correlation between normalized cerebral rSO2 and SpO2 values was highly significant (Pearson correlation coefficient = 0.893). Prior to correlation analyses, the values were normalized by dividing them by the individual means of stable pre-apneic measurements. Cerebral rSO2 measured re-saturation after termination of apnea significantly earlier (10 s, SD = 3.6 s) compared to SpO2 monitoring (21 s, SD = 4.4 s) [t(9) = 7.703, p < 0.001, r(2) = 0.868]. Our data demonstrate that NIRS monitoring reliably measures dynamic changes in cerebral tissue oxygen saturation, and identifies successful re-saturation faster than SpO2. Measuring cerebral rSO2 may prove beneficial in case of respiratory emergencies and during pulseless situations where SpO2 monitoring is impossible.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Evaluation of near-infrared spectroscopy under apnea-dependent hypoxia in humans

Eichhorn

Erdfelder

Kessler

et al. 2015

J Clin Monit Comput

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“…It has the advantage of supplying a noninvasive, real-time, bedside measurement of cerebral oxygenation and hemodynamics which can be critical for the medical team to initiate interventions to maintain a safe cerebral oxygenation level. 10,14 The purpose of this study is to assess the performance of noninvasive NIRS monitoring and hemodynamic variables as predictors of survival and NDO in neonates with CHD undergoing cardiac surgery.…”

Section: Introductionmentioning

confidence: 99%

Cerebral tissue oxygenation index and lactate at 24 hours postoperative predict survival and neurodevelopmental outcome after neonatal cardiac surgery

Aly

Zurakowski

Glass

et al. 2016

Congenital Heart Disease

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“…Decreasing rSO 2 values are thought to reflect shifts in the delicate balance between cerebral O 2 supply and demand, suggestive of cerebral hypoxia; and indicate the need for interventions aimed at improving cerebral perfusion 33,53 . Similarly, keeping rSO 2 values ≥ 75% of the pre-induction baseline value has been associated with a decreased incidence of post-operative neurological outcomes and shorter hospital stays 12,33 .…”

Section: Discussionmentioning

confidence: 99%

“…By measuring the concentrations of oxygenated haemoglobin (oxyHb) and deoxygenated haemoglobin (deoxyHb), regional cerebral oxygen saturation (rSO 2 ) is determined 37,52,53 . An rSO 2 value greater than 20% below the baseline is indicative of cerebral hypoperfusion and should prompt immediate intervention to improve cerebral oxygenation, and thus prevent cerebral injury 8,12,13,36,51,53 .…”

Section: Non-invasive Neuromonitoringmentioning

confidence: 99%

Use of near‐infrared spectroscopy to identify trends in regional cerebral oxygen saturation in horses

McConnell

Rioja

Bester

et al. 2012

Equine Veterinary Journal

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Summary Reasons for performing study Alterations in cerebral haemodynamics may contribute to perianaesthetic complications in horses. Near‐infrared spectroscopy (NIRS) is frequently used intraoperatively in man to provide information regarding cerebral perfusion. Objectives To determine whether NIRS can identify trends in regional cerebral oxygen saturation (rSO2) in horses and whether there is a correlation between rSO2 and venous oxygen tensions. Methods A cerebral oximeter sensor recorded rSO2 from the dorsal sagittal sinus of 6 healthy horses. Values for rSO2, arterial and venous oxygen and carbon dioxide tensions (PaO2, PvO2, PaCO2 and PvCO2 respectively), along with arteriovenous oxygen saturations (SavO2) were recorded in unsedated (recording period [RP] 1), sedated (RP2) and anaesthetised horses (RP3–5) and during recovery (RP6–8). During anaesthesia, horses were ventilated to achieve states of normo‐ (RP3), hyper‐ (RP4) and hypocapnoea (RP5). Data were evaluated descriptively and analysed using linear mixed‐effects models and Pearson's correlation coefficient. Results Overall mean ± s.d. values for rSO2, PaO2, PvO2, PaCO2, SavO2 and mean arterial pressure varied significantly by RP (P<0.001). Significant decreases in rSO2 were identified between RP1 and the post anaesthetic periods (P<0.001). No significant differences in rSO2 values were identified between RP1 and the intra‐anaesthesia periods or between RP3, RP4 and RP5. Significant correlations were identified between rSO2 and PaO2 (r = 0.448, P<0.001), rSO2 and PvO2 (r = 0.512, P<0.001) and rSO2 and SavO2 (r = 0.469, P<0.001). Conclusions This is the first study to identify trends in rSO2 in horses using NIRS. A positive correlation was identified between rSO2 and PvO2, suggesting that alterations in cerebral oxygenation may be reflected in PvO2. Potential relevance Near‐infrared spectroscopy may be used to monitor trends in rSO2 during equine anaesthesia. Decreasing rSO2 values may act as an early warning signal, alerting clinicians to potential cerebral desaturation events and indicating a need for intervention.

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Near-infrared spectroscopy to monitor cerebral oxygen saturation in single-ventricle physiology

Cited by 22 publications

References 17 publications

Evaluation of near-infrared spectroscopy under apnea-dependent hypoxia in humans

Evaluation of near-infrared spectroscopy under apnea-dependent hypoxia in humans

Cerebral tissue oxygenation index and lactate at 24 hours postoperative predict survival and neurodevelopmental outcome after neonatal cardiac surgery

Use of near‐infrared spectroscopy to identify trends in regional cerebral oxygen saturation in horses

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