Near-infrared spectroscopy in peripheral vascular disease

Abstract

Near-infrared spectroscopy has been performed on the calf muscles of 38 subjects, 21 normal controls without vascular disease and 17 patients with peripheral vascular disease. Oxygen consumption was measured in the calf by calculating the rate of conversion of oxyhaemoglobin to deoxyhaemoglobin during a period of tourniquet-induced ischaemia. Postischaemic reoxygenation was also measured. Median oxygen consumption in patients with peripheral vascular disease was 0.10 ml 100 g tissue-1 min-1, while in the control group it was 0.20 ml 100 g tissue-1 min-1 (P less than 0.03, Mann-Whitney U test). The median time taken to reach maximum oxyhaemoglobin levels after ischaemia was 40 s in patients with peripheral vascular disease and 20 s in controls (P less than 0.02). The results indicate that oxygen consumption is reduced in peripheral vascular disease. Near infrared spectroscopy is a non-invasive method for assessing metabolic improvement resulting from surgical or pharmacological treatment.

Near Infrared Spectroscopy for Noninvasive Assessment of Claudication

“…A possible explanation for this observation is a redistribution of blood in the calf muscle during arterial occlusion. Increase of tHb during arterial occlusion was also found in other studies [13,14].…”

“…In contrast, Cheatle et al [14] found a reduced V02 at rest in claudicants. A possible explanation for this difference is that the claudicants in the present study had not totally recov ered from the walking exercise when arterial occlusion started, which may have overestimated V02 at rest, V02 after walking exercise is more increased in claudi cants than in nonclaudicants.…”

“…Recently the NIRS technique has been used to assess muscle oxygen consumption (V02) in patients with PAOD [14], V 02 at rest was reported to be lower and recovery times after arterial occlusion were longer in PAOD patients compared to nonclaudicants. Arterial inflow capacity was not quan tified.…”

Blood flow and oxygen consumption with near-infrared spectroscopy and venous occlusion: spatial maps and the effect of time and pressure of inflation

“…Reported values of muscle oxygen consumption at rest are in the range 1.8-12.3 mol/100 ml/min. 5,14 By measuring at rest we mean that the protocol does not involve the application of any particular stress to the measured tissue. In measurements at rest, the subject is lying or sitting motionless and no exercise is required.…”

Muscle Blood Flow and Oxygen Utilization Measured by Near-Infrared Spectroscopy during Handgrip Exercise in Chronic Respiratory Patients

“…NIRS blood flows for resting and post-exercise s h o w g o o d a g r e e m e n t w i t h s t r a i n -g a u g e plethysmography 21,32) , although flow measured by plethysmography is generally two to three times higher than the NIRS flow 21,24) . On the other hand, VO 2NIRS using arterial occlusion can be calculated from the rate of decrease in OxyHb [37][38][39][40] or from the rate of decrease in Hbdiff, reflecting the difference between oxyand deoxyhaemoglobin (Hbdiff) 2 0, 22 -2 4, 37 ) . VO 2NIRS during rest proved to be reproducible within one test session 2 3 ) and between test sessions 41) .…”