Near‐infrared spectroscopy for monitoring muscle oxygenation

Boushel, Robert; Piantadosi, Claude A.

doi:10.1046/j.1365-201x.2000.00713.x

Cited by 263 publications

(174 citation statements)

References 31 publications

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“…Using the algorithm developed by Wray et al (55), changes in its redox state correlate closely with flow of reducing equivalents down the phosphorylation pathway and depletion of high-energy metabolites during hypoxia or intense oxidative activity in other tissues (8,37,47). In the present study there was a rapid initial rise in CytOx (i.e., an increase in oxidized CytOx) over the first 2 min of occlusion.…”

Section: Discussionsupporting

confidence: 62%

“…In the present study there was a rapid initial rise in CytOx (i.e., an increase in oxidized CytOx) over the first 2 min of occlusion. In principle, such an increase in CytOx levels could reflect either a reduction in transfer of reducing equivalents from the tricarboxylic acid cycle or an increase in consumption of high-energy metabolites as occurs during maximal oxidative metabolism in muscle (8). The former mechanism seems more likely in the context of the profound, early deoxygenation and suppression of EEG activity in the present study and suggests a rapid decrease in metabolic activity.…”

Section: Discussionmentioning

confidence: 55%

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Regulation of cytochrome oxidase redox state during umbilical cord occlusion in preterm fetal sheep

Roelfsema¹,

Dean²,

Wassink³

et al. 2007

American Journal of Physiology-Regulatory, Integrative and Comp

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The preterm fetus is capable of surviving prolonged periods of severe hypoxia without neural injury for much longer than at term. To evaluate the hypothesis that regulated suppression of brain metabolism contributes to this remarkable tolerance, we assessed changes in the redox state of cytochrome oxidase (CytOx) relative to cerebral heat production, and cytotoxic edema measured using cerebral impedance, during 25 min of complete umbilical cord occlusion or sham occlusion in fetal sheep at 0.7 gestation. Occlusion was followed by rapid, profound reduction in relative cerebral oxygenation and EEG intensity and an immediate increase in oxidized CytOx, indicating a reduction in electron flow down the mitochondrial electron transfer chain. Confirming rapid suppression of cerebral metabolism there was a loss of the temperature difference between parietal cortex and body at a time when carotid blood flow was maintained at control values. As occlusion continued, severe hypotension/hypoperfusion developed, with a further increase in CytOx levels to a plateau between 8 and 13 min and a progressive rise in cerebral impedance. In conclusion, these data strongly suggest active regulation of cerebral metabolism during the initial response to severe hypoxia, which may help to protect the immature brain from injury. asphyxia; preterm; umbilical cord occlusion FETAL AND NEONATAL ANIMALS are well known to be able to survive much longer periods of hypoxia than adults (9, 22). More recently, it has become clear that preterm animals can withstand even longer periods of profound hypoxia and hypotension/hypoperfusion without neural injury than at term (17,28,35). In part, this remarkable tolerance to hypoxia may be related to greater anaerobic capacity in the immature brain (48), but an important additional factor is likely to be actively regulated suppression of cerebral activity. This mechanism, which is mediated by release of endogenous inhibitory neuromodulators such as ␥-aminobutyric acid (GABA) and adenosine during hypoxia, recently has been shown to be active in near-term (0.8 to 0.9 gestation) fetal sheep (6,23,33,49). For example, hypoxemia or adenosine infusion in near-term fetal sheep increased oxidation of cerebral cytochrome oxidase (CytOx) on near-infrared measurements, indicating a rapid reduction in electron flow down the mitochondrial electron transfer chain and, thus, a fall in metabolic activity (40, 41). Conversely, blockade of adenosine A 1 receptor activity during umbilical cord occlusion in near-term fetal sheep accelerated the onset and increased the magnitude of cerebral anoxic cytotoxic edema, with subsequently increased neuronal loss (23).This regulated suppression of metabolic rate during hypoxia or ischemia, before energy stores are depleted, has been termed adaptive hypometabolism (38). It may be of considerable importance not only before birth but also during birth itself and in other settings involving adaptation to low oxygen levels (34). The near-term fetus of the high-altitude, hypoxia-adapted llama...

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Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 55%

Regulation of cytochrome oxidase redox state during umbilical cord occlusion in preterm fetal sheep

Roelfsema¹,

Dean²,

Wassink³

et al. 2007

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Differences in the oxygendependent absorption spectra thus reflect changes in oxygenation at the level of small blood vessels and provide in vivo estimates of the balance between oxygen supply and oxygen consumption. NIRS technique operates in real time and monitors continuously changes in the status of tissue oxygenation [10,13]. A common measurement made with NIRS is muscle oxygenation during exercise.…”

Section: Experimental Approach To the Problemmentioning

confidence: 99%

Interval exercise training improves tissue oxygenation in patients with chronic heart failure

Vasileiadis¹,

Kravari²,

Terrovitis³

et al. 2013

WJCD

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Aim: Aim of our study was to evaluate the effects of interval exercise training (IT) programs, regarding whole body oxygen uptake and peripheral tissue oxygenation, in Chronic Heart Failure (CHF) patients during recovery. Methods: Twenty-six CHF patients (21 males/5 females), mean age of 49 ± 12 years, participated in the study. Fifteen patients were assigned to IT and 11 patients were assigned to IT followed by strength training. All patients were trained for 40 minutes per session, 3 times per week, for 12 weeks. They performed a symptom-limited cardiopulmonary exercise testing (CPET), before and after the completion of the program. Muscle tissue oxygen saturation (StO 2 ) of quadriceps femoris was continuously measured by Near Infrared Spectroscopy (NIRS) during CPET and during the recovery period after the end of exercise. Results: No differences were noted between the two patient groups regarding whole body and peripheral tissue oxygenation indices and, therefore, data from all patients were pooled. After training, an increase in peak oxygen uptake (17 ± 4.5 to 19 ± 5.5 ml/kg/min, p < 0.05), gas exchange threshold (11 ± 3.5 to 12.5 ± 3.5 ml/kg/min, p < 0.05), peak work rate achieved (105 ± 29 to 124 ± 37 Watt, p < 0.05) and the first degree slope of VO 2 at the first minute of recovery (0.45 ± 0.2 to 0.61 ± 0.3 L/min 2 , p < 0.05), was noted. In addition, tissue re-oxygenation time constant was decreased (65 ± 25 to 52 ± 28 sec, p < 0.001). Conclusion: In conclusion, interval exercise training accelerates oxygen uptake and peripheral tissue oxygenation during recovery from exercise in CHF patients.

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“…The chromophores are compounds, which absorb light at a particular wavelength or spectrum. The wavelengths used by NIRS are within the range of 700-1000nm (Boushel & Piantadosi, 2000). The light of NIRS can easily penetrate into the biological tissue and allows detection of changes in specific chromophore concentrations in human tissue.…”

Section: Introductionmentioning

confidence: 99%

Measurement of changes in the oxygenation of quadriceps muscles during the voluntary and involuntary fatigue test in normal healthy sedentary subjects

Rehma¹,

Siddiqui

Darain

2015

jhse

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Rehma, A,R., Siddiqui, M., & Darain, H. (2015) Measurement of changes in the oxygenation of quadriceps muscles during the voluntary and involuntary fatigue test in normal healthy sedentary subjects. J. Hum. Sport Exerc., 10(4), pp.867-882. The Purpose of this study is to investigate the changes in muscle oxygen consumption in response to the different fatigue protocol cycle ergometry and electrical stimulation (voluntary and involuntary) in human quadriceps muscle using near infrared spectroscopy (NIRS). Fifteen healthy sedentary voluntary University students between ages 20-60 were invited to participate in the study. Three minutes stimulation was performed to fatigue the muscle. Changes in muscle oxygenation were measured by near infrared spectroscopy. The present resistance was calculated as the estimated maximal power output. The data were analysed using the Kolmogorov-Smirnov (K-S) test to determine the distribution. Descriptive statistics are used to characterize the shape, central tendency, and variability within a set of data. Differences were tested by utilizing the Friedman test the level of statistical significance was set at P<0.05. There was no significant difference (p>0.05) was found between right leg oxygenated (∆HbO2), deoxygenated (∆HHb), and total haemoglobin (∆CHb) as compared to left leg during cycle ergometry fatigue test. On the other hand, significant difference (p<0.05) was found in oxygenated haemoglobin of right leg when two (cycle ergometry and electrical stimulation) fatigue results were compared. However, no significant difference (p>0.05) was found in deoxygenated (∆HHb) and total haemoglobin (∆CHb) of right leg when two (cycle ergometry and electrical stimulation) fatigue results were compared. There was no significant difference (p>0.05) found in oxygenated, deoxygenated and total haemoglobin between right and left leg cycle ergometry fatigue indices. Similarly, no significant difference (p>0.05) was found in oxygenated, deoxygenated and total haemoglobin of right leg when two (cycle ergometry and electrical stimulation) fatigue indices were compared. The significant difference (p<0.001) were found between two (cycle ergometry and electrical stimulation) fatigue results. This study reveals that the oxygen consumption was more in the electrical stimulation as compared to the cycle ergometry during the fatigue test. Significant difference was observed between the oxygenated haemoglobin when comparing the electrical stimulation with cycle ergometry. Similarly, significant differences were found between the legs in cycle ergometry fatigue test. influences, together with exercise-induced-effects, should be considered as causes. Results show a functioning preparation-system within the DRV for better prepared-junior-athletes to commence the IPCP.

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Near‐infrared spectroscopy for monitoring muscle oxygenation

Cited by 263 publications

References 31 publications

Regulation of cytochrome oxidase redox state during umbilical cord occlusion in preterm fetal sheep

Regulation of cytochrome oxidase redox state during umbilical cord occlusion in preterm fetal sheep

Interval exercise training improves tissue oxygenation in patients with chronic heart failure

Measurement of changes in the oxygenation of quadriceps muscles during the voluntary and involuntary fatigue test in normal healthy sedentary subjects

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