Near-Infrared Spectroscopy: Clinical Use in High-Risk Neonates

Tran, Nhu; Tran, Martin; Lopez, Jeraldine; Ogbaa, Maxine; Votava‐Smith, Jodie K.; Brady, Ken

doi:10.1891/0730-0832/11-t-678

Cited by 3 publications

(2 citation statements)

References 57 publications

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“…Although NIRS has a wide range of applications in the medical field, such as brain function monitoring ( Grossmann, 2008 ; Holper et al, 2019 ), muscle oxygenation monitoring ( Klusiewicz et al, 2021 ), cardiac function monitoring ( Ortega-Loubon et al, 2019 ), neonatal care ( Tran et al, 2021 ), there are rare reports on liquid biopsy- based NIRS for cancer diagnosis. Our previous studies ( Zhu et al, 2023 ; Chen et al, 2021 ) showed a promising diagnostic value in cancer using plasma or pleural effusion.…”

Section: Discussionmentioning

confidence: 99%

Urine based near-infrared spectroscopy analysis reveals a noninvasive and convenient diagnosis method for cancers: a pilot study

Zhu,

Zhang,

Wang

et al. 2023

PeerJ

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Background The challenges in cancer diagnosis underline the need for continued research and development of new diagnostic tools and methods. This study aims to explore an effective, noninvasive, and convenient diagnostic tool using urine based near-infrared spectroscopy (NIRS) analysis combined with machine learning algorithm. Methods Urine samples were collected from a total of 327 participants, including 181 cancer cases and 146 healthy controls. These participants were randomly spit into train set (n = 218) and test set (n = 109). NIRS analysis (4,000 ∼10,000 cm−1) was performed for each sample in both train and test sets. Five pretreatment methods, including Savitzky-Golay (SG) smoothing, multiplicative scatter correction (MSC), baseline removal (BSL) with fitting polynomials to be used as baselines, the first derivative (DERIV1), and the second derivative (DERIV2), and combination with “scaling” and “center”, were investigated. Then partial least-squares (PLS) and linear support-vector machine (SVM) classification models were established, and prediction performance was evaluated in test set. Results NIRS had greatly overlapping in peaks, and PCA analysis failed in separation between cancers and healthy controls. In modeling with urine based NIRS data, PLS model showed its highest prediction accuracy of 0.780, with DERIV2, “scaling” and “center” pretreatment, while linear SVM displayed its best prediction accuracy of 0.844, with raw NIRS. With optimization in SVM, the prediction accuracy could improve to 0.862, when the top 262 features were involved as variables. Discussion This pilot study combining urine based NIRS analysis and machine learning is effective and convenient that might facilitate in cancer diagnosis, encouraging further evaluation with a large-size multi-center study.

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Section: Discussionmentioning

confidence: 99%

Urine based near-infrared spectroscopy analysis reveals a noninvasive and convenient diagnosis method for cancers: a pilot study

Zhu,

Zhang,

Wang

et al. 2023

PeerJ

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“…NIRS is an indirect measure of oxygenation and therefore has several limitations of its application when there is movement, low arterial oxygen levels, darker skin pigmentation, or changes in weight and/or edema ( 146 ). Perhaps the biggest limitation is that there are no established standards and specific guidelines for use and interpretation of NIRS in neonates are lacking.…”

Section: Methods Of Oxygen Measurement and Titrationmentioning

confidence: 99%

Oxygen in the neonatal ICU: a complicated history and where are we now?

Mamidi,

McEvoy

2024

Front. Pediatr.

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Despite major advances in neonatal care, oxygen remains the most commonly used medication in the neonatal intensive care unit (NICU). Supplemental oxygen can be life-saving for term and preterm neonates in the resuscitation period and beyond, however use of oxygen in the neonatal period must be judicious as there can be toxic effects. Newborns experience substantial hemodynamic changes at birth, rapid energy consumption, and decreased antioxidant capacity, which requires a delicate balance of sufficient oxygen while mitigating reactive oxygen species causing oxidative stress. In this review, we will discuss the physiology of neonates in relation to hypoxia and hyperoxic injury, the history of supplemental oxygen in the delivery room and beyond, supporting clinical research guiding trends for oxygen therapy in neonatal care, current practices, and future directions.

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