Near-Infrared Spectroscopic Assessment of Tissue Hydration Following Surgery

Abstract. Diffuse reflectance spectroscopy system was developed for estimation of skin hydration in the near-infrared spectral range of 900-1700 nm. Experimental setup consisted of a near-infrared spectrometer, Y-type fiber optics probe with 1 detection and 6 illumination fibers, halogen-tungsten light source and a PC. By analyzing diffuse reflectance spectrum, a parameter representing skin hydration by performing baseline correction and calculating the area under the 1450 nm water absorption maximum is proposed. A clinical study was performed acquiring data of skin hydration of 39 patients' forearm skin. Results of the developed system are compared to results obtained by a commercial device based on skin conductance measurements. © 2017 Journal of Biomedical Photonics & Engineering.Keywords: Diffuse reflectance; near-infrared; spectroscopy; water; absorption; hydration; skin.

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“…To eliminate scattering effect on OD spectrum, we used linear baseline correction [23] between local minima at 1280 nm and 1650 nm (Fig. 2).…”

Section: Discussionmentioning

confidence: 99%

Comparison of a near-infrared reflectance spectroscopy system and skin conductance measurements for in vivo estimation of skin hydration: a clinical study

Saknīte

Zavorins

Zablocka

et al. 2017

JBPE

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“…For instance, the short wavelength region, 500 -600 nm is dominated by the absorption from oxygenated hemoglobin (HbO2) and deoxygenated hemoglobin (Hb) in the capillary bed of gingival tissue while the absorption from water results in an increased attenuation at longer wavelengths in the 900 -1100 nm region ( Fig. 2) (Sowa et al, 1999;Hanioka et al, 1990). By fitting optical attenuation spectra to the known optical properties (extinction coefficients) of HbO2 and Hb, optical spectroscopy can measure relative concentrations of HbO2 and Hb (Hanioka et al, 1990;Attas et al, 2001).…”

Section: Diagnosis Of Gingivitis By Optical Spectroscopymentioning

confidence: 99%

“…Thus, optical spectroscopy provides a measure of the hemoglobin oxygen saturation of tissues and the degree of tissue perfusion as well as a measure of tissue edema. Based upon these principles, visible -near infrared spectroscopy has been widely applied to biomedical problems, including cancer diagnostics, the early prediction of inflammationrelated treatment failures in burn victims Liu et al, 2005;Sowa et al, 1999) , and monitoring ischemic conditions in urology such as testicular tissue perfusion and oxygenation of testicular torsion (Capraro et al, 2007;Stothers et al, 2008). Commercially, some near infrared based cerebral oximetry monitors, i.e., NIRO and INVOS, have been employed in the clinical settings for the surveillance of the cerebral oxygen balance under CO 2 challenge (Yoshitani et al, 2002).…”

Section: Diagnosis Of Gingivitis By Optical Spectroscopymentioning

confidence: 99%

Diagnosis and Monitoring of Gingivitis in vivo Using Non-Invasive Technology - Infrared Spectroscopy

Liu¹,

Xiang²,

Cholakis³

et al. 2011

Gingival Diseases - Their Aetiology, Prevention and Treatment

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“…9 -14 Recent developments in focal-plane-array detectors for spectroscopic imaging and in the incorporation of improved charge-coupled device (CCD) detectors, along with the im-plementation of liquid crystal tunable filters for spectroscopic wavelength access, support the feasibility of noninvasive hyperspectral imaging approaches in humans. [15][16][17][18][19][20][21] In particular, the visible-reflectance imaging modality allows spatially relevant spectroscopic data to be recorded easily and rapidly from human subjects. With present-day computational power allowing multivariate spectrometric image analyses to be completed within a relatively short period of time, an effective and highly adaptable instrument may be designed with the potential for monitoring broad aspects of tissue perfusion.…”

mentioning

confidence: 99%

Noninvasive Determination of Spatially Resolved and Time-Resolved Tissue Perfusion in Humans During Nitric Oxide Inhibition and Inhalation by Use of a Visible-Reflectance Hyperspectral Imaging Technique

et al. 2001

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Background-Vascular disease is commonly associated with reduced local synthesis of nitric oxide (NO) and impaired tissue perfusion. We introduce a novel noninvasive, visible-reflectance, hyperspectral imaging technique for quantifying the percentage of hemoglobin existing as oxyhemoglobin (HbO 2 ) as an index of skin tissue perfusion. Methods and Results-To simulate vascular endothelial dysfunction, N G -monomethyl-L-arginine (L-NMMA) was infused into the brachial arteries of 9 healthy subjects for 5 minutes to inhibit forearm NO synthesis, first with the subject breathing room air and subsequently during NO inhalation at 80 ppm for 1 hour. Blood flow was measured by venous occlusion plethysmography, and the percentage of HbO 2 perfusing skin tissue was imaged noninvasively with a visible-reflectance hyperspectral technique. L-NMMA reduced blood flow by 31.7Ϯ4.9% and percentage of HbO 2 by 6.5Ϯ0.1 (Pϭ0.002 and PϽ0.001 versus baseline, respectively). With subjects inhaling NO, blood flow fell during L-NMMA infusion by only 10.9Ϯ7.3%, and the percentage of HbO 2 decreased by 3.6Ϯ0.1 (Pϭ0.007 and PϽ0.001, respectively, versus room air L-NMMA responses). Conclusions-Visible-reflectance hyperspectral imaging demonstrates (1) a significant decline in the percentage of HbO 2 in skin tissue when blood flow is reduced after inhibition of forearm NO synthesis and (2) Key Words: peripheral vascular disease Ⅲ blood flow Ⅲ nitric oxide Ⅲ hemoglobin Ⅲ imaging M ore than 10 million Americans have diabetes mellitus, an important risk factor for cardiovascular disease. 1,2 In view of the morbidity and mortality associated with this condition, methods of early detection of vascular disease are needed to initiate appropriate treatment that might lead to an increased life expectancy and enhanced quality of life. Vascular endothelial dysfunction is common in type I and type II diabetes 3,4 and may result in vasoconstriction because of loss of endogenous synthesis of the vasodilating molecule nitric oxide (NO). 5 This, in turn, may compromise blood flow to the extremities of patients with diabetes and other diseases associated with vascular dysfunction, resulting in reduced tissue oxygenation and potentially leading to ulceration, infection, and loss of limb. An impediment to the appropriate clinical management of patients with peripheral arterial disease is the inability to monitor tissue perfusion noninvasively over time. We introduce a novel, noninvasive, visiblereflectance, hyperspectral imaging technique for assessing vascular endothelial dysfunction and its associated reduction in tissue hemoglobin oxygen saturation.Hemoglobin oxygen saturation may be measured by oximeters, although these devices are somewhat limited in usage. For example, a 2-wavelength transmission device restricts measurements to a single point, by which light is passed through either the finger or earlobe. 6 For application to other parts of the body (as, for example, the chest, forehead, or limbs), a transcutaneous reflectance oximeter was developed and f...

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Near-Infrared Spectroscopic Assessment of Tissue Hydration Following Surgery

Cited by 42 publications

References 16 publications

Comparison of a near-infrared reflectance spectroscopy system and skin conductance measurements for in vivo estimation of skin hydration: a clinical study

Comparison of a near-infrared reflectance spectroscopy system and skin conductance measurements for in vivo estimation of skin hydration: a clinical study

Diagnosis and Monitoring of Gingivitis in vivo Using Non-Invasive Technology - Infrared Spectroscopy

Noninvasive Determination of Spatially Resolved and Time-Resolved Tissue Perfusion in Humans During Nitric Oxide Inhibition and Inhalation by Use of a Visible-Reflectance Hyperspectral Imaging Technique

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