Near infrared spectroscopic assessment of engineered cartilage for implantation in a pre-clinical model

Abstract

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Visible and Near-Infrared Spectroscopy Enables Differentiation of Normal and Early Osteoarthritic Human Knee Joint Articular Cartilage

“…Thus, wavelength importance analysis for Classifier 1 showed that the spectral regions responsible for the classification of normal and OA tissue are consistent with absorption regions related to cartilage collagen content (1200–1400 nm) [ 1 , 31 ]. Kendal et al [ 14 , 20 ] have shown that an increasing baseline offset of Vis-NIR spectra reflects matrix maturation in engineered tissue construct. Since significant scattering has been shown in the visible region [ 17 ], the baseline offset in the region (400–600 nm) may reflect a difference in collagen organization between normal and degenerated tissue.…”