Near‐Infrared Responsive PEGylated Gold Nanorod and Doxorubicin Loaded Dissolvable Hyaluronic Acid Microneedles for Human Epidermoid Cancer Therapy

Abstract

Currently, epidermoid cancer is one of the most common malignancies among Caucasians. Traditional treatment may yield uncomfortable side effects for the patient. In order to solve these problems, the authors develop a near-infrared (NIR) responsive PEGylated gold nanorod (GNR-PEG) and doxorubicin (DOX) loaded dissolvable hyaluronic acid (HA) microneedle (GNR-PEG&DOX@HA MN) for human epidermoid cancer therapy. The as-made GNR-PEG&DOX@HA MNs has good skin penetration capability and heating ability. The heating can be transferred to the center of the tumor sites and the temperature is shown to rise up to 60°C within 5 min. Meanwhile, the release behavior of the DOX from GNR-PEG&DOX@HA MNs can be controlled by NIR light. The GNR-PEG&DOX@HA MNs shows good cell inhibition, and the photothermal effect is shown to completely destroy A431 cells in vitro. For in vivo antitumor study, the group treated with GNR-PEG&DOX@HA MNs transcutaneously reveals a remarkable antitumor efficacy, such that all mice are cured without recurrence under only one treatment. Hence, this novel transdermal drug delivery strategy offers hope to human epidermoid cancer therapy, and GNR-PEG&DOX@HA MN may serve as a promising candidate in clinical translation for human epidermoid cancer therapy.

Polymeric Nanoparticles with ROS‐Responsive Prodrug and Platinum Nanozyme for Enhanced Chemophotodynamic Therapy of Colon Cancer

“…In Vitro Cytotoxicity Assay: The cell cytotoxicity assay was investigated using the MTT method. [20] In short, a density of 4 × 10 3 CT26 cells was seeded into a 96-well plate for 24 h. CPT, HPPH, CPT-CC-HPPH NP, CPT-CC-HPPH/Pt NP, CPT-TK-HPPH NP, and CPT-TK-HPPH/Pt NP with various concentrations were added and cultured for 12 h. The cells were treated with or without 660 nm laser irradiation at 200 mW cm −2 for 5 min as designed. The cells were then incubated for 12 and 36 h following the standard MTT method.…”

Microneedle Arrays Combined with Nanomedicine Approaches for Transdermal Delivery of Therapeutics

“…However, finding an administration route for co-delivery has remained a big challenge that can be addressed by MNs. For this purpose, DOX-encapsulated dissolvable hyaluronic acid MNs (DOX-loaded HA MNs) containing a PEGylated gold nanorod (PEGylated-GNR) as a NIR light-responsive agent was developed for human epidermoid cancer therapy [ 131 ]. In this system, PEGylated-GNR acted as a photothermal agent, and hyaluronic MNs presented a high DOX loading capacity and good skin penetration capability.…”

Theranostic Microneedle Devices: Innovative Biosensing and Transdermal Drugs Administration

“…Also anticancer drugs belong to an important field of application of MNDs: two research groups have investigated on DOX administration by means of MNs in [44] and in [45]. Nguyen et al found in vitro studies that Polyvinyl Alcohol (PVA) MNs enhance the transdermal delivery of DOX.…”