Near infrared photothermal conversion materials: mechanism, preparation, and photothermal cancer therapy applications

Li, Jie; Zhang, Wei; Ji, Wenhui; Wang, Jiqing; Wang, Nanxiang; Wu, Wanxia; Wu, Qiong; Hou, Xiaotong; Hu, Wenbo; Li, Lin

doi:10.1039/d1tb01310f

Cited by 219 publications

(152 citation statements)

References 153 publications

Supporting

Mentioning

134

Contrasting

Order By: Relevance

“…Indeed, it has been reported that cancer cells have poor endurance to heat [ 252 ]. The photothermal effect of organic materials is associated with the transition of electrons in molecules when they are irradiated with light subjected to absorption, scattering, and transmission [ 253 ]. Additionally, carbon and inorganic materials, such as metals and metal oxide-based NPs, also offer advantageous photothermal features, as they present high photothermal efficiencies and intrinsic optical properties, such as the localized surface plasmon resonance (LSPR), among others.…”

Section: Light-responsive Polymersomes For Anticancer Therapeutic Del...mentioning

confidence: 99%

“…In the case of PTT, they transform it into heat, increasing the temperature of the milieu, which is also called hyperthermia. In clinical settings, hyperthermia refers to treating diseases, such as cancer, through heating, inducing arduous processes, such as lysis of cell membranes, denaturation of proteins, or even evaporation of cytosol, leading to induced cell death [ 252 , 253 , 254 , 255 , 256 ]. Examples of polymersomes used in PTT are summarized in Table 3 .…”

Section: Light-responsive Polymersomes For Anticancer Therapeutic Del...mentioning

confidence: 99%

See 1 more Smart Citation

Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery

et al. 2022

View full text Add to dashboard Cite

Polymersomes are biomimetic cell membrane-like model structures that are self-assembled stepwise from amphiphilic copolymers. These polymeric (nano)carriers have gained the scientific community’s attention due to their biocompatibility, versatility, and higher stability than liposomes. Their tunable properties, such as composition, size, shape, and surface functional groups, extend encapsulation possibilities to either hydrophilic or hydrophobic cargoes (or both) and their site-specific delivery. Besides, polymersomes can disassemble in response to different stimuli, including light, for controlling the “on-demand” release of cargo that may also respond to light as photosensitizers and plasmonic nanostructures. Thus, polymersomes can be spatiotemporally stimulated by light of a wide wavelength range, whose exogenous response may activate light-stimulable moieties, enhance the drug efficacy, decrease side effects, and, thus, be broadly employed in photoinduced therapy. This review describes current light-responsive polymersomes evaluated for anticancer therapy. It includes light-activable moieties’ features and polymersomes’ composition and release behavior, focusing on recent advances and applications in cancer therapy, current trends, and photosensitive polymersomes’ perspectives.

show abstract

Section: Light-responsive Polymersomes For Anticancer Therapeutic Del...mentioning

confidence: 99%

Section: Light-responsive Polymersomes For Anticancer Therapeutic Del...mentioning

confidence: 99%

Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Interestingly, some tumor tissues faded away at the end of treatment with Ti 3 C 2 -Gel and NIR radiation. During the treatment, the temperature of the tumor tissues increased to 50°C within 2 min, which can disrupt the cell membranes of cancer cells; the underlying mechanisms resulting from PTT have been reported as follows: 1) inhibition of DNA, RNA, and protein synthesis at high temperatures; 2) changes in cell membrane permeability; 3) induction of immunogenic death of cancer cells due to the release of tumor-specific antigens; and 4) production of blood vessel spasms that result in intravascular thrombosis of tumor tissue ( Liu et al, 2019b ; Poursalehi et al, 2019 ; Ye et al, 2019 ; Shang et al, 2020 ; Chang et al, 2021 ; Li et al, 2021 ).…”

Section: Resultsmentioning

confidence: 99%

Injectable and Temperature-Sensitive Titanium Carbide-Loaded Hydrogel System for Photothermal Therapy of Breast Cancer

Yao

Zhu

Peng

et al. 2021

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Recently, organic–inorganic hybrid materials have gained much attention as effective photothermal agents for cancer treatment. In this study, Pluronic F127 hydrogel-coated titanium carbide (Ti3C2) nanoparticles were utilized as an injectable photothermal agent. The advantages of these nanoparticles are their green synthesis and excellent photothermal efficiency. In this system, lasers were mainly used to irradiate Ti3C2 nanoparticles to produce a constant high temperature, which damaged cancer cells. The nanoparticles were found to be stable during storage at low temperatures for at least 2 weeks. The Ti3C2 nanoparticles exhibited a shuttle-shaped structure, and the hydrogels presented a loosely meshed structure. In addition, Ti3C2 nanoparticles did not affect the reversible temperature sensitivity of the gel, and the hydrogel did not affect the photothermal properties of Ti3C2 nanoparticles. The in vitro and in vivo results show that this hydrogel system can effectively inhibit tumor growth upon exposure to near-infrared irradiation with excellent biocompatibility and biosafety. The photothermal agent-embedded hydrogel is a promising photothermal therapeutic strategy for cancer treatment by enhancing the retention in vivo and elevating the local temperature in tumors.

show abstract

“…Photothermal conversion efficiency is defined as converting absorbed light energy into localized heat and usually mentioned as a percentage ( Table 2 ) [ 93 ]. Plasmonic NPs possess a wide conversion efficiency range in the NIR-I and NIR-II regions [ 83 , 92 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 ].…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle-Mediated Photothermal Therapy Limitation in Clinical Applications Regarding Pain Management

et al. 2022

View full text Add to dashboard Cite

The development of new effective cancer treatment methods has attracted much attention, mainly due to the limited efficacy and considerable side effects of currently used cancer treatment methods such as radiation therapy and chemotherapy. Photothermal therapy based on the use of plasmonically resonant metallic nanoparticles has emerged as a promising technique to eradicate cancer cells selectively. In this method, plasmonic nanoparticles are first preferentially uptaken by a tumor and then selectively heated by exposure to laser radiation with a specific plasmonic resonant wavelength, to destroy the tumor whilst minimizing damage to adjacent normal tissue. However, several parameters can limit the effectiveness of photothermal therapy, resulting in insufficient heating and potentially leading to cancer recurrence. One of these parameters is the patient’s pain sensation during the treatment, if this is performed without use of anesthetic. Pain can restrict the level of applicable laser radiation, cause an interruption to the treatment course and, as such, affect its efficacy, as well as leading to a negative patient experience and consequential general population hesitancy to this type of therapy. Since having a comfortable and painless procedure is one of the important treatment goals in the clinic, along with its high effectiveness, and due to the relatively low number of studies devoted to this specific topic, we have compiled this review. Moreover, non-invasive and painless methods for temperature measurement during photothermal therapy (PTT), such as Raman spectroscopy and nanothermometry, will be discussed in the following. Here, we firstly outline the physical phenomena underlying the photothermal therapy, and then discuss studies devoted to photothermal cancer treatment concerning pain management and pathways for improved efficiency of photothermal therapy whilst minimizing pain experienced by the patient.

show abstract

Near infrared photothermal conversion materials: mechanism, preparation, and photothermal cancer therapy applications

Abstract: Photothermal therapy (PTT) has been widely applied in cancer therapy as a result of its non-invasive, localized treatment and good therapeutic effect. In general, the final therapeutic effect of PTT...

Cited by 219 publications

References 153 publications

Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery

Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery

Injectable and Temperature-Sensitive Titanium Carbide-Loaded Hydrogel System for Photothermal Therapy of Breast Cancer

Nanoparticle-Mediated Photothermal Therapy Limitation in Clinical Applications Regarding Pain Management

Contact Info

Product

Resources

About