Near infrared photolysis of a Ru polypyridyl complex by upconverting nanoparticles

Ruggiero, Emmanuel; Habtemariam, Abraha; Yate, Luis; Mareque‐Rivas, Juan C.; Salassa, Luca

doi:10.1039/c3cc47601d

Cited by 51 publications

(51 citation statements)

References 23 publications

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“…However, a new approach that is currently gaining momentum may help overcome this problem: the use in photochemotherapy of compounds and materials designed to upconvert near-infrared light into higher-energy visible photons. It has been applied to activation of ruthenium complexes suggested as prodrugs for photoactivatable anticancer therapy (59,60). Perhaps, the same or similar compounds could help trigger the azobenzene photoisomerization in lipid amphiphiles by infrared light.…”

Section: Phototriggerable Flipidsmentioning

confidence: 99%

Fliposomes: stimuli-triggered conformational flip of novel amphiphiles causes an instant cargo release from liposomes

Samoshin

2014

Biomolecular Concepts

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This review presents a new strategy for the design of stimuli-responsive liposomes for targeted delivery - the construction of a liposome membrane (lipid bilayer) using amphiphiles able to perform a stimuli-triggered conformational flip ('flipids'). When done simultaneously by a major or significant part of the bilayer molecules, this massive flip disrupts the liposome membrane and induces a rapid release of the liposome load specifically in response to the initial stimulus. The conformational switches incorporated into the amphiphilic molecules could potentially be controlled by various internal or external factors (pH, metal complexation, light, electric field, etc.). Using this concept, we designed a series of pH-triggerable flipids, and prepared and tested 'fliposomes' with extraordinary characteristics: high stability in storage and in serum combined with an instant release of their cargo in response to a weakly acidic medium.

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Section: Phototriggerable Flipidsmentioning

confidence: 99%

Fliposomes: stimuli-triggered conformational flip of novel amphiphiles causes an instant cargo release from liposomes

Samoshin

2014

Biomolecular Concepts

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“…[29,30] Previous systems have successfully used ruthenium compounds, often coupled with upconverting nanoparticles, to achieve near-IR activation of the ruthenium and release of active protein. [31,32] …”

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confidence: 99%

Ruthenium‐Crosslinked Hydrogels with Rapid, Visible‐Light Degradation

Rapp

Highley

Manor

et al. 2018

Chemistry A European J

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Incorporation of photoresponsive molecules within soft materials can provide spatiotemporal control over bulk properties and address challenges in targeted delivery and mechanical variability. However, the kinetics of in situ photochemical reactions are often slow and typically employ ultraviolet wavelengths. Here, we present a novel photoactive crosslinker Ru(bipyridine) (3-pyridinaldehyde) (RuAldehyde), which was reacted with hydrazide-functionalized hyaluronic acid to form hydrogels capable of encapsulating protein cargo. Visible light irradiation (400-500 nm) initiated rapid ligand exchange on the ruthenium center, which degraded the hydrogel within seconds to minutes, depending on gel thickness. An exemplar enzyme cargo, TEM1 β-lactamase, was loaded into and photoreleased from the Ru-hydrogel. To expand their applications, Ru-hydrogels were also processed into microgels using a microfluidic platform.

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“…Ford and co-workers showedt hat the NIR irradiation of UCNPs loaded with either the Roussin black salt anion or the photoactivated CO-releasing moiety (photoCORM) trans-[Mn(2,2'-bipyridine)(PPh 3 ) 2 (CO) 2 ] results in the release of NO and CO, respectively. [13,14] Similarly, we have demonstrated that related upconversion nanosystems promoted the release of pyridine fromaR u-polypyridyl complex [16] and the generation of aP t II speciesf rom aP t IV prodrug candidate. [17] Alternatively,H ee tal.…”

Section: Introductionmentioning

confidence: 92%

Upconverting Nanoparticles Prompt Remote Near‐Infrared Photoactivation of Ru(II)–Arene Complexes

Ruggiero

Garino

Mareque‐Rivas

et al. 2016

Chemistry A European J

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The synthesis and full characterisation (including X-ray diffraction studies and DFT calculations) of two new piano-stool Ru(II) -arene complexes, namely [(η(6) -p-cym)Ru(bpy)(m-CCH-Py)][(PF)6]2 (1) and [(η(6) -p-cym)Ru(bpm)(m-CCH-Py)][(PF)6]2 (2; p-cym=p-cymene, bpy=2,2'-bipyridine, bpm=2,2'-bipyrimidine, and m-CCH-Py=3-ethynylpyridine), is described and discussed. The reaction of the m-CCH-Py ligand of 1 and 2 with diethyl-3-azidopropyl phosphonate by Cu-catalysed click chemistry affords [(η(6) -p-cym)Ru(bpy)(P-Trz-Py)][(PF)6]2 (3) and [(η(6) -p-cym)Ru(bpm)(P-Trz-Py)][(PF)6]2 (4; P-Trz-Py=[3-(1-pyridin-3-yl-[1,2,3]triazol-4-yl)-propyl]phosphonic acid diethyl ester). Upon light excitation at λ=395 nm, complexes 1-4 photodissociate the monodentate pyridyl ligand and form the aqua adduct ions [(η(6) -p-cym)Ru(bpy)(H2O)](2+) and [(η(6) -p-cym)Ru(bpm)(H2O)](2+). Thulium -doped upconverting nanoparticles (UCNPs) are functionalised with 4, thus exploiting their surface affinity for the phosphonate group in the complex. The so-obtained nanosystem UCNP@4 undergoes near-infrared (NIR) photoactivation at λ=980 nm, thus producing the corresponding reactive aqua species that binds the DNA-model base guanosine 5'-monophosphate.

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Near infrared photolysis of a Ru polypyridyl complex by upconverting nanoparticles

Cited by 51 publications

References 23 publications

Fliposomes: stimuli-triggered conformational flip of novel amphiphiles causes an instant cargo release from liposomes

Fliposomes: stimuli-triggered conformational flip of novel amphiphiles causes an instant cargo release from liposomes

Ruthenium‐Crosslinked Hydrogels with Rapid, Visible‐Light Degradation

Upconverting Nanoparticles Prompt Remote Near‐Infrared Photoactivation of Ru(II)–Arene Complexes

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