Near-Infrared Photobiomodulation in an Animal Model of Traumatic Brain Injury: Improvements at the Behavioral and Biochemical Levels

Quirk, Brendan J.; Torbey, Michel T.; Buchmann, Ellen; Verma, Sumit; Whelan, Harry T.

doi:10.1089/pho.2012.3261

Cited by 65 publications

(48 citation statements)

References 20 publications

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“…15 Quirk et al 34 used the TruScan nose poke test to follow the response of Sprague-Dawley rats with CCI-TBI to tLLLT (670 nm, 5 min, 50 mW∕cm 2 , 15 J∕cm 2 ) per day for 10 days. They found significant reductions in task entries, repeat entries, and task errors that coincided with a decrease in Bax and an increase in Bcl2.…”

Section: Discussionmentioning

confidence: 99%

Transcranial low-level laser therapy enhances learning, memory, and neuroprogenitor cells after traumatic brain injury in mice

Xuan¹,

et al. 2014

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Abstract. The use of transcranial low-level laser (light) therapy (tLLLT) to treat stroke and traumatic brain injury (TBI) is attracting increasing attention. We previously showed that LLLT using an 810-nm laser 4 h after controlled cortical impact (CCI)-TBI in mice could significantly improve the neurological severity score, decrease lesion volume, and reduce Fluoro-Jade staining for degenerating neurons. We obtained some evidence for neurogenesis in the region of the lesion. We now tested the hypothesis that tLLLT can improve performance on the Morris water maze (MWM, learning, and memory) and increase neurogenesis in the hippocampus and subventricular zone (SVZ) after CCI-TBI in mice. One and (to a greater extent) three daily laser treatments commencing 4-h post-TBI improved neurological performance as measured by wire grip and motion test especially at 3 and 4 weeks post-TBI. Improvements in visible and hidden platform latency and probe tests in MWM were seen at 4 weeks. Caspase-3 expression was lower in the lesion region at 4 days post-TBI. Double-stained BrdU-NeuN (neuroprogenitor cells) was increased in the dentate gyrus and SVZ. Increases in double-cortin (DCX) and TUJ-1 were also seen. Our study results suggest that tLLLT may improve TBI both by reducing cell death in the lesion and by stimulating neurogenesis.

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Section: Discussionmentioning

confidence: 99%

Transcranial low-level laser therapy enhances learning, memory, and neuroprogenitor cells after traumatic brain injury in mice

Xuan¹,

et al. 2014

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“…In addition to its beneficial effects observed on a variety of clinical conditions, much attention has been currently given to the satisfactory results observed on functional and structural brain injuries such as traumatic brain injuries resulting in behavioral, cognitive, and biochemical changes [14,15]. Significant results were seen when TCLT was applied to patients suffering from depression and anxiety [16], in neurodegenerative diseases such as Parkinson's and Alzheimer's diseases experimentally induced in rats [17,18], and in cerebral blood flow disruption [19] among others.…”

Section: Overview Of the Use Of Led In Medical Sciencementioning

confidence: 99%

Transcranial Light Emitting Diode Therapy (TCLT) and its Effects on Neurological Disorders

RB¹

2015

J Bioeng Biomed Sci

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The Transcranial LED Therapy (TCLT) is a modality of low-level energy therapy based on the principle of photons delivered in a non-invasive manner for the rehabilitation of some neurological conditions such as psychological disorders, traumatic brain injuries, and neurodegenerative diseases among others. Because the phototherapy approach has attracted interest in the scientific medical field we discuss the action of TCLT at the cellular level in this review. Cytochrome c oxidase is the main target of TCLT for therapeutic effects by enhancing cerebral blood flow. This enzyme boosts cell respiration and energy production, which induces cell proliferation and reduces apoptosis in Alzheimer and Parkinson's diseases. Thus, TCLT is a safe, non-invasive, and low cost alternative treatment compared to other treatment modalities for clinical neurological disorders.

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“…Recently, researchers have shifted the focus of research to the application of LLLT on brain disorders [1][2][3]. During the past decade, LLLT has been widely used to study neurological and psychological diseases [3] such as depressionlike behaviors [4][5][6][7][8], Alzheimer's disease (AD) [9][10][11][12][13][14][15][16][17][18][19][20], Parkinson's disease [21], stroke [22,23] and traumatic brain injury (TBI) [24][25][26][27][28][29][30][31][32]. Because red or NIR light can effectively penetrate into brain tissues [33,34], it can be noninvasive and play a beneficial role in increasing ATP biosynthesis and neurogenesis [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…Transcranial LLLT improved neuromuscular performance, increased brain derived neurotrophic factor (BDNF), reduced brain lesion volume, enhanced learning and memory, and overall improved the neurological severity score in mouse model of TBI [24,25,[28][29][30][31][32]. In addition, the clinical studies found that LLLT could improve cognition and decrease depression, anxiety, headache and insomnia in patients with chronic Review Xiang-Ping Chu and long-term spatial and recognition memory impairments in rats that were injected bilaterally with Aβ 1-42 to the hippocampus CA1 region [9].…”

Section: Introductionmentioning

confidence: 99%

Transcranial Low-Level Laser Therapy for Depression and Alzheimer’s Disease

Chang¹,

Ren²,

Wang³

et al. 2018

Neuropsychiatry

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There is no effective therapy in patients with depression and Alzheimer's disease (AD). The need for novel treatments offers researchers the opportunity to explore new technology for these disorders. Transcranial low-level laser therapy (LLLT) is a novel therapeutic approach based on laser irradiation to biological tissue, and it has been used to treat brain disorders. Although there are certain therapeutic options for depression and AD, there is little treatment available as non-invasive physical therapy. In this mini-review, we focus on a growing body of evidence surrounding the therapeutic effects of LLLT for depression and AD. Transcranial LLLT can enhance ATP biosynthesis, regulate mitochondrial homeostasis, and facilitate neurogenesis and/or neuroplasticity. However, the cellular and molecular mechanisms underlying the treatment of LLLT on these disorders are still at early stages. Clinical trials on depression and AD by transcranial LLLT are critical for future studies.

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Near-Infrared Photobiomodulation in an Animal Model of Traumatic Brain Injury: Improvements at the Behavioral and Biochemical Levels

Cited by 65 publications

References 20 publications

Transcranial low-level laser therapy enhances learning, memory, and neuroprogenitor cells after traumatic brain injury in mice

Transcranial low-level laser therapy enhances learning, memory, and neuroprogenitor cells after traumatic brain injury in mice

Transcranial Light Emitting Diode Therapy (TCLT) and its Effects on Neurological Disorders

Transcranial Low-Level Laser Therapy for Depression and Alzheimer’s Disease

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