Near-Infrared Photoactivatable Oxygenation Catalysts of Amyloid Peptide

Ni, Jizhi; Taniguchi, Atsuhiko; Ozawa, Shuta; Hori, Yukiko; Kuninobu, Yoichiro; Saito, Takashi; Saido, Takaomi C.; Tomita, Taisuke; Sohma, Youhei; Kanai, Motomu

doi:10.1016/j.chempr.2018.02.008

Cited by 73 publications

(62 citation statements)

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“…53,54 Photo-oxygenating Ab is capable of disintegrating Ab aggregates through increasing the protein polarity, which is an attractive strategy for AD therapy. [55][56][57][58] However, in the presence of Cu, just oxygenating Ab may not entirely block its brillation because Cu can still promote protein aggregation by coordinating to Ab. Considering that Cu and Ab are two critical pathogenic factors of AD, 59,60 we envisioned that in situ synthesized bifunctional drug agent with Ab-oxygenating and Cu-chelating properties could effectively disassemble Ab-Cu aggregates in vivo.…”

Section: Resultsmentioning

confidence: 99%

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Self-triggered click reaction in an Alzheimer's disease model:in situbifunctional drug synthesis catalyzed by neurotoxic copper accumulated in amyloid-β plaques

et al. 2019

Chem. Sci.

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Section: Resultsmentioning

confidence: 99%

“…S15 †). 55,61 Ab40 (10 mM) and compound 6 (20 mM) were irradiated with UV light (1 W cm À2 ) for 1 h and then photooxygenated Ab was detected by MS. Fig. S16 † illustrates that both compounds 4 and 6 can effectively oxygenate Ab40.…”

Section: Resultsmentioning

confidence: 99%

Self-triggered click reaction in an Alzheimer's disease model:in situbifunctional drug synthesis catalyzed by neurotoxic copper accumulated in amyloid-β plaques

et al. 2019

Chem. Sci.

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“…To solve this issue, chemical strategies have also been applied to suppress Aβ aggregation and downstream toxicity for AD treatment. Although inconsistent and even contradictory to the discussed antioxidative therapy, several reports have indicated that the oxidative modification of Aβ peptides may contribute to the inhibition of Aβ aggregation and the improvement of AD treatment . These efforts involve the harvesting of external optical energy to activate photocatalysts and facilitate ROS generation in pathological region, thus acquiring therapeutic effect.…”

Section: Nanocatalytic Medicine For Nontumoral Therapiesmentioning

confidence: 99%

Nanocatalytic Medicine

2019

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Catalysis and medicine are often considered as two independent research fields with their own respective scientific phenomena. Promoted by recent advances in nanochemistry, large numbers of nanocatalysts, such as nanozymes, photocatalysts, and electrocatalysts, have been applied in vivo to initiate catalytic reactions and modulate biological microenvironments for generating therapeutic effects. The rapid growth of research in biomedical applications of nanocatalysts has led to the concept of “nanocatalytic medicine,” which is expected to promote the further advance of such a subdiscipline in nanomedicine. The high efficiency and selectivity of catalysis that chemists strived to achieve in the past century can be ingeniously translated into high efficacy and mitigated side effects in theranostics by using “nanocatalytic medicine” to steer catalytic reactions for optimized therapeutic outcomes. Here, the rationale behind the construction of nanocatalytic medicine is eludicated based on the essential reaction factors of catalytic reactions (catalysts, energy input, and reactant). Recent advances in this burgeoning field are then comprehensively presented and the mechanisms by which catalytic nanosystems are conferred with theranostic functions are discussed in detail. It is believed that such an emerging catalytic therapeutic modality will play a more important role in the field of nanomedicine.

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“…The cytotoxicity of the RB-treated Aβ42 peptides was also remarkably reduced compared with the untreated one. Similar lightinduced inhibition was also reported using ruthenium (II) complex[168], porphyrins[21], carbenoxolone[169] and CRANAD-2 derivatives[170]. For in vivo studies, light penetration is a challenge in order to achieve the needed light-induced inhibition.…”

supporting

confidence: 63%

“…By introducing a bromine atom into an amyloid dye, CRANAD-2, they created a photoactivatable oxygenation catalyst that can be turned on under NIR irradiation. The tissue permeability of NIR light makes it possible to function under mouse skin and even inside mouse brains[170].…”

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confidence: 99%

Investigation into multifunctional nanoparticles for the detection, imaging and intervention of amyloid

Xia¹

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Amyloid is defined as insoluble, extracellular, proteinous aggregates formed by misfolding of proteins or peptides which are normally soluble. In the human body, amyloid is toxic and can cause cell death. Therefore, the presence of amyloid is linked with several diseases, including Alzheimer's disease (AD), spongiform encephalopathies and type II diabetes, which are also referred as amyloidosis. AD is one of the most well-known amyloidoses. In AD, the amyloid aggregates appear predominantly in the patients' brain, composed by a certain group of peptides known as amyloid beta (Aβ) peptides. Current clinical diagnoses of AD are primarily based on cognitive symptoms. However, it is often too late for intervention when the symptoms are detectable and there is no effective treatment for AD. On the other hand, the onset of amyloid aggregation may start years before the appearance of AD symptoms. Therefore, the detection and intervention of AD related amyloid at the molecular level are expected to be developed as powerful diagnostic and therapeutic methods for AD. Nanoparticle facilitated therapy and diagnosis have recently achieved impressive success in biomedical researches, especially in oncology studies. Compared to small molecule based probes and drugs, nanoparticles are capable to generate more comprehensive diagnosis, enhanced therapeutic effect, and better specific targeting. However, the reported applications of nanoparticles for AD research are still limited. In this context, by identifying the aforementioned research gap, this thesis aims to investigate the potential of nanoparticles for the early detection, imaging, and intervention of amyloid. To fulfill this objective, three nanoparticles: gold nanoparticles (AuNPs), carbon dots (C-dots) and iron oxide nanoparticles (IONPs), have been selected due to their unique physiochemical properties.

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Near-Infrared Photoactivatable Oxygenation Catalysts of Amyloid Peptide

Cited by 73 publications

References 38 publications

Self-triggered click reaction in an Alzheimer's disease model:in situbifunctional drug synthesis catalyzed by neurotoxic copper accumulated in amyloid-β plaques

Self-triggered click reaction in an Alzheimer's disease model:in situbifunctional drug synthesis catalyzed by neurotoxic copper accumulated in amyloid-β plaques

Nanocatalytic Medicine

Investigation into multifunctional nanoparticles for the detection, imaging and intervention of amyloid

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