Near-infrared (NIR) laparoscopy for intraoperative lymphatic road-mapping and sentinel node identification during definitive surgical resection of early-stage colorectal neoplasia

Ra, Chisei; Anderson, Mark J.; Wang, Lai Mun; Lindsey, Ian; Cunningham, Chris; Mortensen, Neil

doi:10.1007/s00464-011-1854-3

Cited by 148 publications

(128 citation statements)

References 31 publications

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“…Quick switch of NIRF imaging facilitated the confirmation of mesocolic lymphatic drainage patterns and the identification of SLNs. 169 The aforementioned studies ascertain the effectiveness of NIRF imaging in clinical settings. NIRF imaging has been experiencing explosive development and will be employed in more operating rooms and other biomedical applications.…”

mentioning

confidence: 99%

Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field

Yi¹,

Wang²,

Qin³

et al. 2014

IJN

211

149

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Near-infrared fluorescence (NIRF) imaging is an attractive modality for early cancer detection with high sensitivity and multi-detection capability. Due to convenient modification by conjugating with moieties of interests, NIRF probes are ideal candidates for cancer targeted imaging. Additionally, the combinatory application of NIRF imaging and other imaging modalities that can delineate anatomical structures extends fluorometric determination of biomedical information. Moreover, nanoparticles loaded with NIRF dyes and anticancer agents contribute to the synergistic management of cancer, which integrates the advantage of imaging and therapeutic functions to achieve the ultimate goal of simultaneous diagnosis and treatment. Appropriate probe design with targeting moieties can retain the original properties of NIRF and pharmacokinetics. In recent years, great efforts have been made to develop new NIRF probes with better photostability and strong fluorescence emission, leading to the discovery of numerous novel NIRF probes with fine photophysical properties. Some of these probes exhibit tumoricidal activities upon light radiation, which holds great promise in photothermal therapy, photodynamic therapy, and photoimmunotherapy. This review aims to provide a timely and concise update on emerging NIRF dyes and multifunctional agents. Their potential uses as agents for cancer specific imaging, lymph node mapping, and therapeutics are included. Recent advances of NIRF dyes in clinical use are also summarized.

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mentioning

confidence: 99%

Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field

Yi¹,

Wang²,

Qin³

et al. 2014

IJN

211

149

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“…Several studies have found that the detection rate for sentinel nodes using ICG is relatively high [23, 25, 27-30]. The studies varied in their method of instilling the tracer, with some using laparoscopic insertion of the dye through the serosa and others using colonoscopic administration.…”

Section: Resultsmentioning

confidence: 99%

Intraoperative Sentinel Node Mapping in the Colon: Potential and Pitfalls

Currie¹

2019

Eur Surg Res

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Sentinel lymph node mapping (SLNM) may play a significant role in future delivery of colon cancer surgery because of an increase in early-stage, node-negative disease due to national bowel cancer screening programmes. Traditionally, colon lymphatic drainage has not been thought relevant as the operative approach cannot be tailored. Recent advances in local and endoscopic risk-reducing interventions for colonic malignancy have caused a rethink in approach. SLNM was initially attempted with blue dye techniques with limited success. Technological improvement has allowed surgeons to use near-infrared (NIR) light and NIR active tracers such as indocyanine green. This review provides an overview of the current status of intraoperative lymph node mapping in the colon, identifies challenges to the delivery of the techniques, and discusses potential solutions that may help SLNM play a role in improving the delivery of surgical care for patients with colon cancer.

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“…39 In turn, the increase in exposure times during NIR fluorescence detection resulted in low acquisition frame rates making this approach impractical for real-time ergonomic clinical use. Furthermore, the potential of NIR fluorescence-guided endoscopic imaging is highlighted by the development of commercial clinically compatible systems optimized for NIR fluorescence imaging (e.g., Storz FL series 40 and Novadaq spyscope 41 ). These systems are, however, either designed for single-channel imaging (i.e., either color or NIR), or present a significant amount of fluorescence background.…”

Section: Introductionmentioning

confidence: 99%

Design and characterization of an optimized simultaneous color and near-infrared fluorescence rigid endoscopic imaging system

et al. 2013

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Abstract. We report the design, characterization, and validation of an optimized simultaneous color and near-infrared (NIR) fluorescence rigid endoscopic imaging system for minimally invasive surgery. This system is optimized for illumination and collection of NIR wavelengths allowing the simultaneous acquisition of both color and NIR fluorescence at frame rates higher than 6.8 fps with high sensitivity. The system employs a custom 10-mm diameter rigid endoscope optimized for NIR transmission. A dual-channel light source compatible with the constraints of an endoscope was built and includes a plasma source for white light illumination and NIR laser diodes for fluorescence excitation. A prism-based 2-CCD camera was customized for simultaneous color and NIR detection with a highly efficient filtration scheme for fluorescence imaging of both 700-and 800-nm emission dyes. The performance characterization studies indicate that the endoscope can efficiently detect fluorescence signal from both indocyanine green and methylene blue in dimethyl sulfoxide at the concentrations of 100 to 185 nM depending on the background optical properties. Finally, we performed the validation of this imaging system in vivo during a minimally invasive procedure for thoracic sentinel lymph node mapping in a porcine model.

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Near-infrared (NIR) laparoscopy for intraoperative lymphatic road-mapping and sentinel node identification during definitive surgical resection of early-stage colorectal neoplasia

Cited by 148 publications

References 31 publications

Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field

Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field

Intraoperative Sentinel Node Mapping in the Colon: Potential and Pitfalls

Design and characterization of an optimized simultaneous color and near-infrared fluorescence rigid endoscopic imaging system

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