Near-Infrared Light-Triggered Switchable Nanoparticles for Targeted Chemo/Photothermal Cancer Therapy

Abstract

Accumulation of nanoparticles in solid tumors depends on their extravasation, but their efficacy is often compromised by intrinsic physiological heterogeneity in tumors. The conventional solutions to circumvent this problem are size control of nanoparticles or increasing the vascular permeability. The aim of this study is to investigate the combination effect of size variation of stimuli-responsive nanoparticles and improved vascular permeability triggered by near-infrared (NIR) light irradiation. Doxorubicin (DOX), a clinically proven drug for bladder cancer, was encapsulated in the nanocomposites with high loading content up to 45%. We show that NIR light-responsive size-switchable nanocarriers could considerably enhance the tumor-targeting of DOX in bladder tumor-bearing mice. Moreover, a combination of NIR-induced hyperthermia and DOX-mediated chemotherapy resulted in remarkable inhibition of tumor growth in mice. Histological results suggest that the change in morphology of tumor microvasculature may account for enhanced extravasation and accumulation of the nanodrugs upon NIR irradiation. Together, these data suggest that external stimuli-responsive drug delivery system offers a safe and effective means of targeted chemo/photothermal therapy.

Human cytotoxic T-lymphocyte membrane-camouflaged nanoparticles combined with low-dose irradiation: a new approach to enhance drug targeting in gastric cancer

“…51 External stimuli, including variations in temperature, magnetic fields, 52,53 and NIR light, 54,55 have been well employed in drug delivery systems in previous studies. However, compared with the LDI in this study, externally placed magnets have no antitumor efficacy themselves, while NIR light or thermotherapy are not widely applied.…”

Recent progress on nanoparticle-based drug delivery systems for cancer therapy

“…The pRGO@MS (DOX)-HA showed excellent photothermal properties and good dispersibility under NIR laser irradiation. Gao et al 62 developed a thermal/pH dual-sensitive nanocarrier for the treatment of bladder cancer. Their results revealed that chemo/photothermal targeted therapy might be more advantageous than conventional therapeutics for bladder cancer.…”

Polymer-Based Nanocarriers for Co-Delivery and Combination of Diverse Therapies against Cancers

“…In the scope of this review, frames are (but not limited to) carbon-based nanomaterials (mesoporous carbon nanoparticle, graphene, graphene oxide, single- or multi-walled carbon nanotubes, etc.) [ 29 , 36 , 37 , 39 , 41 , 59 , 63 , 66 , 68 , 79 , 94 , 95 , 96 , 97 , 98 ], silica-based nanomaterials [ 30 , 31 , 93 , 99 ], nanogold materials [ 75 , 77 , 78 , 99 , 100 , 101 , 102 , 103 ], polydopamine (PDA) [ 28 , 47 , 67 ], polypyrrole (PPy) [ 27 , 49 , 69 , 70 , 71 , 72 , 73 , 94 ], metal organic frameworks [ 73 , 104 ], Prussian blue [ 104 , 115 ], other inorganic materials [ 22 , 35 , 69 , 105 ,…”