Near infrared light-triggered on-demand Cur release from Gel-PDA@Cur composite hydrogel for antibacterial wound healing

Tao, Bailong; Lin, Changjian; Yuan, Zhangfu; He, Ye; Chen, Maowen; Li, Ké; Hu, Jingwei; Yang, Yulu; Xia, Zengzilu; Cai, Kaiyong

doi:10.1016/j.cej.2020.126182

Cited by 160 publications

(122 citation statements)

References 68 publications

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“…High temperature could cause enzyme inactivation, cell membrane permeability changes [ 66 , 82 ], cytoplasmic outflow [ 66 ], and protein denaturation [ 94 ] ( Figure 1 ). The cell membranes of Escherichia coli became shrunken and blurred after NIR irradiation, and the integrity of the cell membranes was destroyed, indicating that high temperature can destroy bacterial cell membranes [ 95 ]. Moreover, Li et al demonstrated that the photothermal effect can destroy bacterial cell membranes, denature bacterial proteins, and change cell membrane permeability [ 96 ].…”

Section: Potential Mechanisms Of Photothermal Hydrogels For Wound Healing and Tissue Engineeringmentioning

confidence: 99%

“…Under NIR irradiation, curcumin can be released rapidly compared to only a slight release without NIR. This phenomenon can be attributed to the fact that π−π stacking and hydrogen bonds can be destroyed by hyperthermia [ 95 , 109 ]. Doxycycline, as a broad-spectrum antibiotic agent, has been used widely in clinical practice [ 110 ].…”

Section: Potential Mechanisms Of Photothermal Hydrogels For Wound Healing and Tissue Engineeringmentioning

confidence: 99%

mentioning

confidence: 99%

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A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

Zhang

Tan

et al. 2021

Polymers

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Photothermal treatment (PTT) is a promising strategy to deal with multidrug-resistant bacteria infection and promote tissue regeneration. Previous studies demonstrated that hyperthermia can effectively inhibit the growth of bacteria, whereas mild heat can promote cell proliferation, further accelerating wound healing and bone regeneration. Especially, hydrogels with photothermal properties could achieve remotely controlled drug release. In this review, we introduce a photothermal agent hybrid in hydrogels for a photothermal effect. We also summarize the potential mechanisms of photothermal hydrogels regarding antibacterial action, angiogenesis, and osteogenesis. Furthermore, recent developments in photothermal hydrogels in wound healing and bone regeneration applications are introduced. Finally, future application of photothermal hydrogels is discussed. Hydrogels with photothermal effects provide a new direction for wound healing and bone regeneration, and this review will give a reference for the tissue engineering.

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Section: Potential Mechanisms Of Photothermal Hydrogels For Wound Healing and Tissue Engineeringmentioning

confidence: 99%

Section: Potential Mechanisms Of Photothermal Hydrogels For Wound Healing and Tissue Engineeringmentioning

confidence: 99%

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A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

Zhang

Tan

et al. 2021

Polymers

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“…PDA-NPs possess excellent photothermal conversion property that could efficiently convert NIR light into heat. Both Han and Tao et al ( Han et al, 2016 ; Tao et al, 2021 ) used PDA-NPs to prepare NIR light stimuli-responsive hydrogels. Enhanced elasticity, biocompatibility, tissue-adhesiveness, and more importantly, bacteria-killing ability by photothermal effect were achieved in the composite hydrogels, showing promising future as wound dressings to accelerate skin tissue repair.…”

Section: Biomedical Applications Of Pda-nps In Tementioning

confidence: 99%

Research Progress on Polydopamine Nanoparticles for Tissue Engineering

et al. 2021

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Tissue engineering is an interdisciplinary field that aims to develop biological substitutes for the replacement, repair, or enhancement of tissue function. The physical and chemical characteristics of biomaterials exert a profound influence on the biological responses and the following biofunction. Nanostructured coatings have been widely applied as an effective surface modification strategy to improve the bioactivity of biomaterials. Especially, polydopamine and polydopamine-derived nanoparticles are found with excessive adhesiveness, redox activity, photothermal conversion capacity, paramagnetism and conductivity other than excellent biocompatibility, and hydrophilicity. In this article, advances about polydopamine nanoparticles in tissue engineering applications are reviewed, including the repair of bone, cartilage, skin, heart, and nerve, to provide strategies for future biomaterial design.

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“…24 Meanwhile, photothermal therapy (PTT) has little damage to the body and hardly develops drug resistance, which is the best choice for preventing wound infection. 25,26 In current studies, various photothermal agents were used in wound dressings such as graphene oxide (GO), 27,28 polydopamine nanoparticles (PDA-NPs) 29,30 and carbon nanotube (CNT). 31 Among them, GO as a two-dimensional nanomaterial has been widely employed for its excellent NIR absorption and conversion capabilities.…”

Section: Introductionmentioning

confidence: 99%

N‐dodecylated chitosan/graphene oxide composite cryogel for hemostasis and antibacterial treatment

Qiu

Dong

Zhao

et al. 2021

J of Applied Polymer Sci

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Uncontrolled massive bleeding remains a global issue, which requires an exigent response for safe and efficient hemostat. However, most of hemostats without antimicrobial property could trigger serious bacterial infection problem. Herein, a composite cryogel was synthesized by double bond N-dodecylated chitosan (DCSG) and graphene oxide (GO). The cryogel (DCSG/GO) with macroporous structure exhibited high-fluid adsorption ability, excellent mechanical property, and fluid-triggered shape recovery performance. Moreover, the in vitro blood coagulation experiments proved that DCSG/ GO 5% possessed better coagulation efficiency than medical gelatin sponge. And the DCSG/GO 5% cryogel exhibited more erythrocyte and platelets activation. Besides, the cryogel had excellent near-infrared (NIR)-assisted photothermal antibacterial activity against both Escherichia coli and Staphylococcus aureus and killed 99% of them after 20 min NIR irradiation. In addition, the vitro hemolysis and cytotoxicity results proved the well biocompatibility of cryogel. Therefore, the biocompatible DCSG/GO cryogel has great potential application prospect in clinical hemorrhage control and anti-infection treatment.

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Near infrared light-triggered on-demand Cur release from Gel-PDA@Cur composite hydrogel for antibacterial wound healing

Cited by 160 publications

References 68 publications

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

Research Progress on Polydopamine Nanoparticles for Tissue Engineering

N‐dodecylated chitosan/graphene oxide composite cryogel for hemostasis and antibacterial treatment

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