Near-infrared light-responsive supramolecular nanovalve based on mesoporous silica-coated gold nanorods

Li, Hui; Tan, Lili; Jia, Ping; Li, Qinglan; Sun, Yulong; Zhang, Jian; Ning, Yin; Yu, Jihong; Yang, Ying‐Wei

doi:10.1039/c4sc00198b

Cited by 218 publications

(117 citation statements)

References 45 publications

(69 reference statements)

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“…It was found that the stimulation of NIR light could obviously trigger drug release from WS 2 -IO@MS-PEG/DOX (Fig. 2b), similar to the behaviors of many other mesoporous silica coated photothermal nano-carriers [1,54,55]. Interestingly, the NIR light responsiveness of our nanocarrier was particularly sensitive within the acidic environment.…”

Section: Preparation and Characterization Of Ws 2 -Io@ms-peg/doxsupporting

confidence: 71%

Two-dimensional magnetic WS2@Fe3O4 nanocomposite with mesoporous silica coating for drug delivery and imaging-guided therapy of cancer

et al. 2015

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Section: Preparation and Characterization Of Ws 2 -Io@ms-peg/doxsupporting

confidence: 71%

Two-dimensional magnetic WS2@Fe3O4 nanocomposite with mesoporous silica coating for drug delivery and imaging-guided therapy of cancer

et al. 2015

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“…32 Various simple and robust methods have been reported for the synthesis of multifunctional mesoporous silica-encapsulated AuNPs (core-shell Au@mSiO 2 NPs) for use as cancer theranostics. 33,34 Previously, we successfully designed and synthesized Janus Au@mSiO 2 NPs, which might not only efficiently deliver imaging agents or drugs into cancer cells but also exhibit good photothermal properties, thus representing a promising theranostic candidate for use in combined photothermo-/chemo-cancer therapy. 30 Given …”

Section: Discussionmentioning

confidence: 99%

Cytotoxicity of various types of gold-mesoporous silica nanoparticles in human breast cancer cells

Liu

et al. 2015

IJN

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Recently, gold nanoparticles (AuNPs) have shown promising biological applications due to their unique electronic and optical properties. However, the potential toxicity of AuNPs remains a major hurdle that impedes their use in clinical settings. Mesoporous silica is very suitable for the use as a coating material for AuNPs and might not only reduce the cytotoxicity of cetyltrimethylammonium bromide-coated AuNPs but might also facilitate the loading and delivery of drugs. Herein, three types of rod-like gold-mesoporous silica nanoparticles (termed bare AuNPs, core–shell Au@mSiO 2 NPs, and Janus Au@mSiO 2 NPs) were specially designed, and the effects of these AuNPs on cellular uptake, toxic behavior, and mechanism were then systematically studied. Our results indicate that bare AuNPs exerted higher toxicity than the Au@mSiO 2 NPs and that Janus Au@mSiO 2 NPs exhibited the lowest toxicity in human breast cancer MCF-7 cells, consistent with the endocytosis capacity of the nanoparticles, which followed the order, bare AuNPs > core–shell Au@mSiO 2 NPs > Janus Au@mSiO 2 NPs. More importantly, the AuNPs-induced apoptosis of MCF-7 cells exhibited features that were characteristic of intracellular reactive oxygen species (ROS) generation, activation of c-Jun-N-terminal kinase (JNK) phosphorylation, an enhanced Bax-to-Bcl-2 ratio, and loss of the mitochondrial membrane potential. Simultaneously, cytochrome c was released from mitochondria, and the caspase-3/9 cascade was activated. Moreover, both ROS scavenger ( N -acetylcysteine) and JNK inhibitor (SP600125) partly blocked the induction of apoptosis in all AuNPs-treated cells. Taken together, these findings suggest that all AuNPs induce apoptosis through the ROS-/JNK-mediated mitochondrial pathway. Thus, Janus Au@mSiO 2 NPs exhibit the potential for applications in biomedicine, thus aiding the clinical translation of AuNPs.

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“…[40] The use of GNR allowed the authors to use near infrared light (NIR, 808 nm) to create heat around the nanodevice ( Figure 5). [40] The use of GNR allowed the authors to use near infrared light (NIR, 808 nm) to create heat around the nanodevice ( Figure 5).…”

Section: Plasmonic Heatingmentioning

confidence: 99%

Externally Controlled Nanomachines on Mesoporous Silica Nanoparticles for Biomedical Applications

2016

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Many machines (including nanomachines) consist of a solid support with moving parts that can undergo large amplitude motion to carry out specific tasks. In this Minireview, we will describe nanomachines that are supported on mesoporous silica nanoparticles that are typically 50-100 nanometers in diameter and have an array of open, readily accessible pores with an average width of a few nanometers. For triggering a large amplitude motion of the moving parts, we will focus primarily on external stimuli such as heat or light. As for the specific task the machines are carrying out, this Minireview will focus on the controlled release of pharmaceutically active agents in biomedical applications. We will discuss examples of how nanomachines can be used for remotely controlled cargo release and how existing machines that were originally designed to respond to internal physiological stimuli could be reconfigured to respond to external stimuli instead.

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Near-infrared light-responsive supramolecular nanovalve based on mesoporous silica-coated gold nanorods

Cited by 218 publications

References 45 publications

Two-dimensional magnetic WS2@Fe3O4 nanocomposite with mesoporous silica coating for drug delivery and imaging-guided therapy of cancer

Two-dimensional magnetic WS2@Fe3O4 nanocomposite with mesoporous silica coating for drug delivery and imaging-guided therapy of cancer

Cytotoxicity of various types of gold-mesoporous silica nanoparticles in human breast cancer cells

Externally Controlled Nanomachines on Mesoporous Silica Nanoparticles for Biomedical Applications

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