Near-infrared light-responsive, pramipexole-loaded biodegradable PLGA microspheres for therapeutic use in Parkinson's disease

Li, Shuang; Liu, Jiaxin; Li, Ge; Zhang, Xueyan; Xu, Fengyuan; Fu, Zhijiang; Teng, Lesheng; Li, Youxin; Sun, Fengying

doi:10.1016/j.ejpb.2019.05.013

Cited by 17 publications

(12 citation statements)

References 22 publications

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“…Phasic as opposed to continuous release of bioactive agents has implications for the improved treatment of a variety of diseases, including cancer 43 , osteoporosis 44,45 and neurological disorders 10 . Existing ultrasound and NIR-releasing systems, such as DOPE liposomes 17 and pramipexole PLGA microspheres 46 , use minutes of stimulus to create phasic or stepwise concentration changes on an hour timescale. In contrast, the HGN-liposome system can be activated with both NIR 9,10 and ultrasound stimuli on a second timescale to create burst concentrations lasting for seconds to minutes.…”

Section: Discussionmentioning

confidence: 99%

Dynamic control of neurochemical release with ultrasonically-sensitive nanoshell-tethered liposomes

et al. 2019

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The unique surface plasmon resonance of hollow gold nanoshells can be used to achieve drug release from liposomes upon laser stimulation, and adapted to mimic the intricate dynamics of neurotransmission ex vivo in brain preparations. However, to induce a physiological response in vivo requires the degree of temporal precision afforded by laser stimulation, but with a greater depth of penetration through tissue. Here we report that the attachment of hollow gold nanoshells to the surface of robust liposomes results in a construct that is highly sensitive to ultrasonic stimulation. The resulting construct can be remotely triggered by low intensity, therapeutic ultrasound. To our knowledge, this is the first example of nanoparticleliposome system that can be activated by both laser and acoustic stimulation. The system is capable of encapsulating the neurochemical dopamine, and repeatedly releasing small amounts on-demand in a circulating environment, allowing for precise spatiotemporal control over the release profile.

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Section: Discussionmentioning

confidence: 99%

Dynamic control of neurochemical release with ultrasonically-sensitive nanoshell-tethered liposomes

et al. 2019

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“…The formed emulsion was suspended in more volume of PVA (0.1% w/v) and hardened to make microspheres. Microspheres were [102] Human growth hormone (hGH) P L G A -g r a f t e d d e x t r a n ( D e x -g -P L G A ) g r a f t copolymers [99]. Generally, methylene chloride (dichloromethane) is used as organic phase and PVA (polyvinyl alcohol) is used as aqueous phase in the formulation of s-o-w emulsion [100][101][102][103][104][105].…”

Section: Plga Microspheres Containing Pramipexole-hgns For Parkinson's Diseasementioning

confidence: 99%

“…The optimum drug release profile of s-o-w system facilitated the Sprague-Dawley (SD) rat’s neurons to quickly retrieve from damage caused by MPTP as exhibited by immunohistochemistry and pharmacodynamic studies. TEM analysis of HGNS morphology revealed a near-spherical shape and uniform size distribution without apparent aggregation indicating a stable emulsion [ 99 ].…”

Section: Types Of Emulsionsmentioning

confidence: 99%

Solid-in-Oil-in-Water Emulsion: An Innovative Paradigm to Improve Drug Stability and Biological Activity

Sawant

Kamath

et al. 2021

AAPS PharmSciTech

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An emulsion is a biphasic dosage form comprising of dispersed phase containing droplets that are uniformly distributed into a surrounding liquid which forms the continuous phase. An emulsifier is added at the interface of two immiscible liquids to stabilize the thermodynamically unstable emulsion. Various types of emulsions such as water-in-oil (w-o), oil-in-water (o-w), microemulsions, and multiple emulsions are used for delivering certain drugs in the body. Water (aqueous) phase is commonly used for encapsulating proteins and several other drugs in water-in-oil-in-water (w-o-w) emulsion technique. But this method has posed certain problems such as decreased stability, burst release, and low entrapment efficiency. Thus, a novel “solid-in-oil-in-water” (s-o-w) emulsion system was developed for formulating certain drugs, probiotics, proteins, antibodies, and tannins to overcome these issues. In this method, the active ingredient is encapsulated as a solid and added to an oil phase, which formed a solid-oil dispersion. This dispersion was then mixed with water to form a continuous phase for enhancing the drug absorption. This article focuses on the various studies done to investigate the effectiveness of formulations prepared as solid-oil-water emulsions in comparison to conventional water-oil-water emulsions. A summary of the results obtained in each study is presented in this article. The s-o-w emulsion technique may become beneficial in near future as it has shown to improve the stability and efficacy of the entrapped active ingredient. Graphical abstract

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“…Parkinson's disease (PD) is the second most prevalent chronic and progressive neurodegenerative disorder (Li et al, 2019), resulting in damage to extrapyramidal motor neurons and ultimately leading to symptoms including akinesia, resting tremor, muscle rigidity, bradykinesia, and postural abnormalities (Ascherio & Schwarzschild, 2016; Masellis et al, 2016). Statistically, nearly 1%–2% of the global population with the age of more than 65 years affected symptomatic disease, which could place an untenable burden on patients (Motyl, Przykaza, Boguszewski, Kosson, & Strosznajder, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…The new generation of smart drug delivery exerted appropriate temporal and spatial control of drug release, enhance drug efficacy, and decrease systemic toxicity non‐invasively (Li et al, 2019). Poly(lactic‐co‐glycolic acid) (PLGA), an aliphatic polyester, is well known for its biocompatibility biodegradability, and minimal toxicity, and wide used in medical applications, nanotechnology, and tissue engineering (Danhier et al, 2012; Fan, Chi, et al, 2019; Fan, Cui, et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Vascular endothelial growth factor‐loaded poly‐lactic‐co‐glycolic acid nanoparticles with controlled release protect the dopaminergic neurons in Parkinson's rats

et al. 2020

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Vascular endothelial growth factor (VEGF) had neuroprotective effects on dopaminergic (DA) neurons. In order to overcome the gastrointestinal digestion and bioaccessibility, VEGF was encapsulated with poly-lactic-co-glycolic acid nanospheres (NS) in order to prevent the VEGF degradation until its release. The caudal administration of VEGF and NS encapsulated VEGF at different doses (1.0, 10.0, and 100.0 ng/ ml) on the rats with Parkinson's disease lesion was evaluated. Intravenous injected VEGF at the dose of 1 ng/ml displayed the strongest neuroprotective effect than other groups as well as the stereotaxic group. The NS encapsulated with VEGF can pass through blood-brain barrier and protect the DA neurons. There was no significant difference between intravenous injection method and stereotaxic method, while the first method is simpler and convenient. Injection of NS encapsulated with VEGF may become a valuable neurorescuing therapeutic approach for Parkinson's disease.

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Near-infrared light-responsive, pramipexole-loaded biodegradable PLGA microspheres for therapeutic use in Parkinson's disease

Cited by 17 publications

References 22 publications

Dynamic control of neurochemical release with ultrasonically-sensitive nanoshell-tethered liposomes

Dynamic control of neurochemical release with ultrasonically-sensitive nanoshell-tethered liposomes

Solid-in-Oil-in-Water Emulsion: An Innovative Paradigm to Improve Drug Stability and Biological Activity

Vascular endothelial growth factor‐loaded poly‐lactic‐co‐glycolic acid nanoparticles with controlled release protect the dopaminergic neurons in Parkinson's rats

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