Near-infrared light-responsive multifunctional hydrogel releasing peptide-functionalized gold nanorods sequentially for diabetic wound healing

Recent advances of hydrogels as smart dressings for diabetic wounds

“…135 To this end, researchers have developed smart hydrogels containing metal photosensitizers, such as gold nanorods and copper nanoparticles, which can exert synergistic effects with PTT through the slow release of inorganic metal ions to enhance antibacterial efficacy. 136,137 PDT is more selective than PTT and mainly exerts its effect through the short-range diffusion of ROS. 138 Wang et al synthesized a wolf-tooth-like Au–CuS heterostructure nanoparticle (gAu–CuS HS) and loaded it into an injectable hydrogel composed of silk fibroin and hyaluronic acid for the treatment of diabetic wounds.…”

Stimulus-Responsive Bioactive Hydrogels in Diabetic Wound Healing

“…44 In another report, a bioactive hydrogel system with two-stage near-infrared (NIR) sequential release was developed (Figure 9B). 18 The bioactive hydrogel could shrink thermally responsively prepared by NG layer and AP layer. NG layer contained gelatin methacrylate (GelMA) and poly(N-isopropylacrylamide)/gelatin methacrylate (PNIPAm) while AP layer was made of polyacrylamide (PAAm), which mean this hydrogel possess biocompatible properties, good stability and stretchability.…”

Thermo‐Responsive Hydrogels Coupled with Photothermal Agents for Biomedical Applications

“…Diabetic wounds are one kind of chronic wounds, that often stagnate in the inflammatory phase, due to excessive production of reactive oxygen species (ROS), dysregulation of proinflammatory cytokines and proteases. [219,220] Excessive production of ROS will hamper wound healing by causing irreversible oxidative damage to biological molecules and cells. What's more, bacterial infection is often found in diabetic wounds owing to impaired immune responses, and bacterial infection will intensify ROS production and aggravate the inflammatory response.…”