Near infrared light responsive hybrid nanoparticles for synergistic therapy

Liang, Yan; Gao, Wenxia; Peng, Xinyu; Deng, Xianjun; Sun, Changzhen; Wu, Haixia; He, Bin

doi:10.1016/j.biomaterials.2016.05.023

Cited by 52 publications

(39 citation statements)

References 53 publications

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“…Then, the dialysis tube was immersed into a 50 mL tube containing 20 mL dextrose solution (fraction 5%) in a shaker at 37°C and 120 rpm. At predetermined times (5,10,15,20,30,45, and 60 min), 5 mL of the external dextrose solution was replaced with the corresponding fresh dextrose solution. The concentration of Gd(III) was determined by ICP-AES, and I -was measured using the chloric acid method.…”

Section: Ltca Releasementioning

confidence: 99%

“…13 Upon near-infrared (NIR) light laser irradiation, the dissipation of absorbed light energy as heat can not only mediate hyperthermia of tumor with high spatial and temporal resolution but also activate the rapid release of contents at the site of interest. [14][15][16][17] The introducing of the light-triggered release systems in CA delivery will help to utilize the self-quench property of fluorescence at high concentrations, and has been used for optic imaging. 18 However, previous reports on light-triggered nanotheranostics mostly focused on cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Near-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy

Wu¹,

Wang²,

Lu³

et al. 2017

IJN

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The major challenge in current clinic contrast agents (CAs) and chemotherapy is the poor tumor selectivity and response. Based on the self-quench property of IR820 at high concentrations, and different contrast effect ability of Gd-DOTA between inner and outer of liposome, we developed “bomb-like” light-triggered CAs (LTCAs) for enhanced CT/MRI/FI multimodal imaging, which can improve the signal-to-noise ratio of tumor tissue specifically. IR820, Iohexol and Gd-chelates were firstly encapsulated into the thermal-sensitive nanocarrier with a high concentration. This will result in protection and fluorescence quenching. Then, the release of CAs was triggered by near-infrared (NIR) light laser irradiation, which will lead to fluorescence and MRI activation and enable imaging of inflammation. In vitro and in vivo experiments demonstrated that LTCAs with 808 nm laser irradiation have shorter T 1 relaxation time in MRI and stronger intensity in FI compared to those without irradiation. Additionally, due to the high photothermal conversion efficiency of IR820, the injection of LTCAs was demonstrated to completely inhibit C6 tumor growth in nude mice up to 17 days after NIR laser irradiation. The results indicate that the LTCAs can serve as a promising platform for NIR-activated multimodal imaging and photothermal therapy.

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Section: Ltca Releasementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Near-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy

Wu¹,

Wang²,

Lu³

et al. 2017

IJN

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“…These results further proved that DOX-loaded gels had better inhibition effect on tumours. Metastasis and invasion always go with angiogenesis in the process of growth for solid tumours [46]. In order to research the tumour suppression mechanism and the antitumour efficacy, the Ki-67 and CD31 antigen staining were evaluated to assess the antitumour efficacy on tumour cell proliferation, and TUNEL assay was performed to research the apoptotic programmed cell death as shown in Figure 8.…”

Section: Resultsmentioning

confidence: 99%

Effective combination therapy of percutaneous ethanol injection and chemotherapy based on injectable low molecular weight gels

Liang

Sun

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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Percutaneous ethanol injection (PEI) therapy was used in liver cancer treatment, however, the therapeutic ethanol in PEI easily flew away from injected solid tumours and hinder the treatment effect. In this paper, injectable supramolecular gels formed by self-assembly of low molecular weight gelators (LMWGs) based on glycylglycine modified phenylboronic acid were prepared to localize ethanol and load chemotherapeutic drug for in situ synergistic therapy. The mechanism, morphology and rheological property of supramolecular gels were characterized by NMR, UV, SEM, etc. The rheological study revealed that the gels were formed in situ rapidly and recovered promptly once damaged. The gels were non-toxicity to both normal 3T3 fibroblasts cells and 4T1 breast cancer cells. Doxorubicin (DOX) hydrochloride and ethanol were encapsulated in the gels for the combination of chemotherapy and PEI therapy. The in vivo anticancer activity of the DOX-loaded gels was carried out in tumour bearing mice. The injected gels were coated around tumour tissues to lock ethanol, and DOX was released sustainingly from the gels to maintain effective concentration to induce the apoptosis of tumour cells. DOX-loaded gels and the ethanol exhibited excellent therapeutic efficacy and low side effects in local cancer therapy.

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“…Cytotoxicity assay. The biocompatibility of probes in living cells is an important consideration (30,31). In the current study, the ICG and IR787 probes were evaluated in vitro to determine any cytotoxicity in A549 cells using the MTT method.…”

Section: Characterizationmentioning

confidence: 99%

Novel near‑infrared fluorescent probe for live cell imaging

2019

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Near infrared (NIR) fluorescent probes play a crucial role in biological system imaging. A novel NIR fluorescent probe, IR787, was designed in the present study. Compared with indocyanine green (ICG), IR787 showed lower background fluorescent interference and higher fluorescence enhancement. Fluorescence intensities were detected by a Cary Eclipse fluorescence spectrophotometer. The interference of intracellular ions (Cu 2+ , Ca 2+ , Mg 2+ and Zn 2+) on the measurement was negligible, which indicated a good photostability of IR787. MTT assay demonstrated that cell viability of human lung adenocarcinoma epithelial cell line A549 was not significantly affected by the use of the IR787 probe compared with the ICG probe. This result suggested that the IR787 probe was safe for in vitro cell imaging. In vitro NIR optical imaging experiments further revealed cellular uptake and strong intracellular NIR fluorescence of the IR787 probe in A549 cells. The excitation wavelength was 787 nm for IR787. Compared with the previously reported NIR fluorescent probe ICG, the IR787 NIR fluorescent probe had improved prospects for intracellular imaging. IR787 may play a pivotal role in the understanding cell biology, pharmacology and disease diagnosis.

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Near infrared light responsive hybrid nanoparticles for synergistic therapy

Cited by 52 publications

References 53 publications

Near-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy

Near-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy

Effective combination therapy of percutaneous ethanol injection and chemotherapy based on injectable low molecular weight gels

Novel near‑infrared fluorescent probe for live cell imaging

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