Near-infrared imaging of brain tumors using the Tumor Paint BLZ-100 to achieve near-complete resection of brain tumors

Butte, Pramod; Mamelak, Adam N.; Parrish-Novak, Julia; Drazin, Doniel; Shweikeh, Faris; Gangalum, Pallavi R.; Chesnokova, Alexandra; Ljubimova, Julia Y.; Black, Keith L.

doi:10.3171/2013.11.focus13497

Cited by 109 publications

(79 citation statements)

References 37 publications

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“…Butte et al presented a NIR imaging probe BLZ-100, using a standard charge-coupled device (CCD) camera to visualize low levels of BLZ-100 binding to the tumors. 157 BLZ-100 exhibited a high affinity for glioma. After injection of BLZ-100 for 48 h, the orthotopic glioma tumors in mice were effectively discriminated from the surrounding normal brain tissue.…”

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confidence: 96%

Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy

et al. 2017

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Surgical resection of solid tumors is currently the gold standard and preferred therapeutic strategy for cancer. Chemotherapy drugs also make a significant contribution by inhibiting the rapid growth of tumor cells and these two approaches are often combined to enhance treatment efficacy. However, surgery and chemotherapy inevitably lead to severe side effects and high systemic toxicity, which in turn results in poor prognosis. Precision medicine has promoted the development of treatment modalities that are developed to specifically target and kill tumor cells. Advances in in vivo medical imaging for visualizing tumor lesions can aid diagnosis, facilitate surgical resection, investigate therapeutic efficacy, and improve prognosis. In particular, the modality of fluorescence imaging has high specificity and sensitivity and has been utilized for medical imaging. Therefore, there are great opportunities for chemists and physicians to conceive, synthesize, and exploit new chemical probes that can image tumors and release chemotherapy drugs in vivo. This review focuses on small molecular ligand-targeted fluorescent imaging probes and fluorescent theranostics, including their design strategies and applications in clinical tumor treatment. The progress in chemical probes described here suggests that fluorescence imaging is a vital and rapidly developing field for interventional surgical imaging, as well as tumor diagnosis and therapy.

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confidence: 96%

Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy

et al. 2017

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“…19,[26][27][28][29][30][31][32][33][34][35][36][37][38][39] The long-term interest in the intraoperative NIR fluorescence visualization is driven by the development of new agents capable of improved delineation of brain tumor margins. Examples of dyes include various derivatives of NIR fluorescent dye currently undergoing preclinical or clinical evaluations, such as BLZ-100, a chlorotoxin-ICG conjugate; 36,37 CLR1502, an alkylphopholine derivative of a cyanine dye; 40,41 anti-EGFR antibody fragments conjugated to IRDye 800 CW; 42,43 and others. 44 We believe that the ability to simultaneously visualize the surgical field and contrast agent within the augmented microscope will enable broad implementation of image guidance in surgeries.…”

Section: Discussionmentioning

confidence: 99%

Augmented microscopy: real-time overlay of bright-field and near-infrared fluorescence images

et al. 2015

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Abstract. Intraoperative applications of near-infrared (NIR) fluorescent contrast agents can be aided by instrumentation capable of merging the view of surgical field with that of NIR fluorescence. We demonstrate augmented microscopy, an intraoperative imaging technique in which bright-field (real) and electronically processed NIR fluorescence (synthetic) images are merged within the optical path of a stereomicroscope. Under luminance of 100,000 lx, representing typical illumination of the surgical field, the augmented microscope detects 189 nM concentration of indocyanine green and produces a composite of the real and synthetic images within the eyepiece of the microscope at 20 fps. Augmentation described here can be implemented as an add-on module to visualize NIR contrast agents, laser beams, or various types of electronic data within the surgical microscopes commonly used in neurosurgical, cerebrovascular, otolaryngological, and ophthalmic procedures.

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“…2). The devices for detecting NIR fluorescence are evolving rapidly and include endoscopes or exoscopes, surgical microscopes, and robotic systems, most incorporating CCD camera technology [49, 50]. Devices that collect and integrate images over short periods of time may have superior sensitivity compared to microscopes, but devices that can display high-definition images in real time will likely be preferred.…”

Section: Device Considerationsmentioning

confidence: 99%

Image-Guided Tumor Resection

2015

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Each year, millions of individuals undergo cancer surgery that is intended to be curative or at least a necessary component of a curative regimen. Particularly for those patients whose cancer harbors cells that are resistant to chemotherapy or radiation, the extent of surgery often defines whether they will be a survivor or casualty of the disease. For many solid tumor types, the difference in survival between patients who undergo gross total resection and those who have residual bulky disease is often profound. With surgery being central to cancer survivorship, it is stunning how few resources have been invested in improving surgical outcomes, particularly in comparison to chemotherapeutic research and discovery. This article reviews recent advances related to developing targeted fluorescent agents to guide surgeons during cancer removal. The goal of these drugs and devices is to clearly distinguish cancer from normal tissue to improve surgical outcome for cancer patients.

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Near-infrared imaging of brain tumors using the Tumor Paint BLZ-100 to achieve near-complete resection of brain tumors

Cited by 109 publications

References 37 publications

Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy

Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy

Augmented microscopy: real-time overlay of bright-field and near-infrared fluorescence images

Image-Guided Tumor Resection

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