Near-infrared II emissive metal clusters: From atom physics to biomedicine

Ma, Huizhen; Wang, Junying; Zhang, Xiaodong

doi:10.1016/j.ccr.2021.214184

Cited by 40 publications

(25 citation statements)

References 387 publications

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“… 16 In general, photon scattering intensity decays exponentially with increasing wavelengths; compared with visible light (400–700 nm) and near-infrared I (NIR-I, 700–900 nm), NIR-II (1000–1700 nm) can provide the highest spatial-temporal resolution with the lowest autofluorescence and deepest penetration, which has attracted much attention in the potential diagnosis. 17 − 19 …”

Section: Introductionmentioning

confidence: 99%

“…In recent years, near-infrared fluorescence imaging technology has played an important role in applications such as biological imaging, − drug distribution tracking, , disease diagnosis, , and tumor imaging. , Compared with routine imaging technologies including computed tomography (CT), positron emission tomography (PET), single-photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), and ultrasound imaging, the greatest advantage of NIR fluorescence imaging is its high spatial resolution due to the reduced photon scattering, light absorption, and autofluorescence background . In general, photon scattering intensity decays exponentially with increasing wavelengths; compared with visible light (400–700 nm) and near-infrared I (NIR-I, 700–900 nm), NIR-II (1000–1700 nm) can provide the highest spatial-temporal resolution with the lowest autofluorescence and deepest penetration, which has attracted much attention in the potential diagnosis. − …”

Section: Introductionmentioning

confidence: 99%

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Electronic and Near-Infrared-II Optical Properties of I-Doped Monolayer MoTe₂: A First-Principles Study

Zhao

Liu

et al. 2022

ACS Omega

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Near-infrared-II (NIR-II, 1000–1700 nm) fluorescence imaging is widely used for in vivo biological imaging. With the unique electronic structures and capability of band-gap engineering, two-dimensional (2D) materials can be potential candidates for NIR-II imaging. Herein, a theoretical investigation of the electronic structure and optical properties of iodine (I)-doped monolayer MoTe 2 systems with different doping concentrations is carried out through simulations to explore their NIR optical properties. The results suggest that the emergence of impurity levels due to I doping effectively reduces the bandwidth of I-doped monolayer MoTe 2 systems, and the bandwidth decreases with the increase in the I doping concentration. Although the I and Mo atoms possess clear covalent-bonding features according to the charge density difference, impurity levels induced by the strong hybridization between the I 5p and Mo 4d orbitals cross the Fermi level, making the doped systems exhibit metallic behavior. In addition, with the increase in the I doping concentration, the energy required for electron transition from valence bands to impurity levels gradually decreases, which can be linked to the enhancement of the optical absorption in the red-shifted NIR-II region. Meanwhile, with a higher I doping concentration, the emission spectra, which are the product of the absorption spectra and quasi-Fermi distributions for electrons and holes, can be enhanced in the NIR-II window.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Electronic and Near-Infrared-II Optical Properties of I-Doped Monolayer MoTe₂: A First-Principles Study

Zhao

Liu

et al. 2022

ACS Omega

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“…Photoluminescence (PL) has long been of major interest in both fundamental research − and practical applications, − particularly, the dual emission phenomena for deciphering the underlying mechanisms and with great potentials in many fields, including ratiometric sensing, bioimaging, solar cells, and even supramolecular encryption systems. , Ultrasmall Au nanoparticles with atomic precision (1–3 nm in diameter), commonly called nanoclusters (NCs), show near-infrared (NIR) PL. − The determined atomic structures and electronic structure calculations allow the elucidation of structure–property correlations, − and the intrinsic merits of Au NCs such as being biocompatible, stable, and nontoxic make this class of materials quite promising for solar energy conversion and biological applications. − So far, dual emission in Au NCs has only been observed in several bitetrahedral kernel structures, and the PL quantum yields (QYs) of those Au NCs in the NIR region were quite low (∼1%) …”

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confidence: 99%

Near-Infrared Dual Emission from the Au₄₂(SR)₃₂ Nanocluster and Tailoring of Intersystem Crossing

Luo

Liu

et al. 2022

J. Am. Chem. Soc.

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This work presents the synthesis and intriguing photoluminescence of the Au 42 (PET) 32 (PET = 2-phenylethanethiolate) nanocluster (NC). The Au 42 (PET) 32 NC exhibits dual emission at 875 and 1040 nm, which are revealed to be fluorescence and phosphorescence, respectively. The emission quantum yield (QY) of Au 42 (PET) 32 in dichloromethane is 11.9% at room temperature in air, which is quite rare for thiolate-protected Au NCs. When Au 42 (PET) 32 NCs are embedded in polystyrene films (solid state), the fluorescence was dramatically suppressed while the phosphorescence was significantly enhanced. This divergent behavior is explained by dipolar interaction-induced enhancement of intersystem crossing from singlet to triplet excited state.

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“…Imaging in the near-infrared II (NIR-II) region of between 1100 and 1700 nm is attracting wide interest due to reduced tissue scattering as compared to the NIR-I region (750–900 nm) . In line with this, Liu et al in 2019 synthesized atomically precise GSH capped Au 25 clusters that emit fluorescence between 1100 and 1350 nm by charge transfer between GSH and the gold core.…”

Section: Auncs In Fluorescent Bioimagingmentioning

confidence: 99%

Gold Nanoclusters: Imaging, Therapy, and Theranostic Roles in Biomedical Applications

et al. 2021

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For the past two decades, atomic gold nanoclusters (AuNCs, ultrasmall clusters of several to 100 gold atoms, having a total diameter of <2 nm) have emerged as promising agents in the diagnosis and treatment of cancer. Owing to their small size, significant quantization occurs to their conduction band, which leads to emergent photonic properties and the disappearance of the plasmonic responses observed in larger gold nanoparticles. For example, AuNCs exhibit native luminescent properties, which have been well-explored in the literature. Using proteins, peptides, or other biomolecules as structural scaffolds or capping ligands, required for the stabilization of AuNCs, improves their biocompatibility, while retaining their distinct optical properties. This paved the way for the use of AuNCs in fluorescent bioimaging, which later developed into multimodal imaging combined with computer tomography and magnetic resonance imaging as examples. The development of AuNC-based systems for diagnostic applications in cancer treatment was then made possible by employing active or passive tumor targeting strategies. Finally, the potential therapeutic applications of AuNCs are extensive, having been used as light-activated and radiotherapy agents, as well as nanocarriers for chemotherapeutic drugs, which can be bound to the capping ligand or directly to the AuNCs via different mechanisms. In this review, we present an overview of the diverse biomedical applications of AuNCs in terms of cancer imaging, therapy, and combinations thereof, as well as highlighting some additional applications relevant to biomedical research.

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Near-infrared II emissive metal clusters: From atom physics to biomedicine

Cited by 40 publications

References 387 publications

Electronic and Near-Infrared-II Optical Properties of I-Doped Monolayer MoTe₂: A First-Principles Study

Electronic and Near-Infrared-II Optical Properties of I-Doped Monolayer MoTe₂: A First-Principles Study

Near-Infrared Dual Emission from the Au₄₂(SR)₃₂ Nanocluster and Tailoring of Intersystem Crossing

Gold Nanoclusters: Imaging, Therapy, and Theranostic Roles in Biomedical Applications

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Near-infrared II emissive metal clusters: From atom physics to biomedicine

Cited by 40 publications

References 387 publications

Electronic and Near-Infrared-II Optical Properties of I-Doped Monolayer MoTe2: A First-Principles Study

Electronic and Near-Infrared-II Optical Properties of I-Doped Monolayer MoTe2: A First-Principles Study

Near-Infrared Dual Emission from the Au42(SR)32 Nanocluster and Tailoring of Intersystem Crossing

Gold Nanoclusters: Imaging, Therapy, and Theranostic Roles in Biomedical Applications

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Product

Resources

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Electronic and Near-Infrared-II Optical Properties of I-Doped Monolayer MoTe₂: A First-Principles Study

Electronic and Near-Infrared-II Optical Properties of I-Doped Monolayer MoTe₂: A First-Principles Study

Near-Infrared Dual Emission from the Au₄₂(SR)₃₂ Nanocluster and Tailoring of Intersystem Crossing