Near-infrared heptamethine cyanine dye-based nanoscale coordination polymers with intrinsic nucleus-targeting for low temperature photothermal therapy

Jiang, Zhenqi; Yuan, Bo; Wang, Yinjie; Wei, Zhenni; Sun, Shan; Akakuru, Ozioma Udochukwu; Li, Yong; Li, Juan; Wu, Aiguo

doi:10.1016/j.nantod.2020.100910

Cited by 57 publications

(39 citation statements)

References 35 publications

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“…The NPs could accumulate in the cell nucleus and release mild heat enough for destroying nuclear DNA under NIR-II light irradiation. Jiang et al synthesized an Hf-heptamethine indocyanine dye- (Hf-HI-4COOH-) based nanoscale coordination polymer (NCP) which possessed strong NIR absorption and excellent photothermal conversion capacity to serve as an intrinsic nucleus-targeting PTA [ 142 ]. Under low-power NIR light irradiation, the NCP could generate enough heat to destroy the nucleus at a mild temperature, leading to the elimination of cancer cells.…”

Section: Applications Of Low-temperature Pttmentioning

confidence: 99%

“…Copyright 2019, Elsevier Ltd. (e) Scheme illustrating the Hf-HI-4COOH NCP structure and nucleus-targeted low-temperature PTT. Reprinted with permission from Reference [ 142 ]. Copyright 2020, Elsevier Ltd. (f) Scheme depicting the synthesis of PEG-PtCNPs and PEG-PtCNPs-RITC and their application for multimodal imaging-guided and multiorganelle-targeted PTT.…”

Section: Figurementioning

confidence: 99%

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Low-Temperature Photothermal Therapy: Strategies and Applications

Duan

2021

Research

102

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Although photothermal therapy (PTT) with the assistance of nanotechnology has been considered as an indispensable strategy in the biomedical field, it still encounters some severe problems that need to be solved. Excessive heat can induce treated cells to develop thermal resistance, and thus, the efficacy of PTT may be dramatically decreased. In the meantime, the uncontrollable diffusion of heat can pose a threat to the surrounding healthy tissues. Recently, low-temperature PTT (also known as mild PTT or mild-temperature PTT) has demonstrated its remarkable capacity of conquering these obstacles and has shown excellent performance in bacterial elimination, wound healing, and cancer treatments. Herein, we summarize the recently proposed strategies for achieving low-temperature PTT based on nanomaterials and introduce the synthesis, characteristics, and applications of these nanoplatforms. Additionally, the combination of PTT and other therapeutic modalities for defeating cancers and the synergistic cancer therapeutic effect of the combined treatments are discussed. Finally, the current limitations and future directions are proposed for inspiring more researchers to make contributions to promoting low-temperature PTT toward more successful preclinical and clinical disease treatments.

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Section: Applications Of Low-temperature Pttmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Low-Temperature Photothermal Therapy: Strategies and Applications

Duan

2021

Research

102

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“…[ 167 ] Moreover, utilizing the interfacial coordination interactions between the Ag + ion at the surface of Ag NPs and O/N atom of a fluorescent cyano‐carboxylic derivative (noted as CECZA), a two‐photon PTT agent was fabricated through self‐assembly of Ag NPs and CECZA, and the assemblies demonstrated good PTT effect on HeLa cells. [ 168 ] Apart from the works mentioned above, there are others studies on the use of the coordination effect derived from V 3+/4+ , [ 24 , 169 ] Zr 4+ , [ 170 ] Ag + , [ 171 ] Hf 4+ , [ 91 , 92 , 93 , 94 ] Sn 4+ , [ 172 ] Re + , [ 173 ] Ir 3+ , [ 174 ] and Bi 3+[ 175 ] to fabricate various nanoplatforms for cancer theranostic investigation.…”

Section: Metal‐coordinated Supramolecular Self‐assemblies For Cancer Theranosticsmentioning

confidence: 99%

Metal‐Coordinated Supramolecular Self‐Assemblies for Cancer Theranostics

Wang

Jin

et al. 2021

Advanced Science

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Metal‐coordinated supramolecular nanoassemblies have recently attracted extensive attention as materials for cancer theranostics. Owing to their unique physicochemical properties, metal‐coordinated supramolecular self‐assemblies can bridge the boundary between traditional inorganic and organic materials. By tailoring the structural components of the metal ions and binding ligands, numerous multifunctional theranostic nanomedicines can be constructed. Metal‐coordinated supramolecular nanoassemblies can modulate the tumor microenvironment (TME), thus facilitating the development of TME‐responsive nanomedicines. More importantly, TME‐responsive organic–inorganic hybrid nanomaterials can be constructed in vivo by exploiting the metal‐coordinated self‐assembly of a variety of functional ligands, which is a promising strategy for enhancing the tumor accumulation of theranostic molecules. In this review, recent advancements in the design and fabrication of metal‐coordinated supramolecular nanomedicines for cancer theranostics are highlighted. These supramolecular compounds are classified according to the order in which the coordinated metal ions appear in the periodic table. Furthermore, the prospects and challenges of metal‐coordinated supramolecular self‐assemblies for both technical advances and clinical translation are discussed. In particular, the superiority of TME‐responsive nanomedicines for in vivo coordinated self‐assembly is elaborated, with an emphasis on strategies that enhance the accumulation of functional components in tumors for an ideal theranostic outcome.

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“…[9] However,t he poor solubility,a cute cytotoxicity and serum instability of these HSPs inhibitors make them fail to completely silence HSPs under complex physiological environment. [10] Moreover,t he intricate fabrication of nanosystems with photothermal agents binding HSPs inhibitors would increase pharmacokinetic uncertainty and difficulty in operation and reduce reproducibility for clinical transformation. Therefore,i t si mperative to develop as ingle component nanomaterial as atherapeutic agent that integrates photothermal conversion capability with HSPs silencing simultaneously for mild PTT.…”

Section: Introductionmentioning

confidence: 99%

“…With the expectation of reducing the cancer cell's thermoresistance, some small molecule HSPs inhibitors have been exploited, such as gambogic acid, 17‐AAG, triptolide, STA‐9090 and etc., to enhance the therapeutic effects of mild PTT [9] . However, the poor solubility, acute cytotoxicity and serum instability of these HSPs inhibitors make them fail to completely silence HSPs under complex physiological environment [10] . Moreover, the intricate fabrication of nanosystems with photothermal agents binding HSPs inhibitors would increase pharmacokinetic uncertainty and difficulty in operation and reduce reproducibility for clinical transformation.…”

Section: Introductionmentioning

confidence: 99%

Single‐Atom Pd Nanozyme for Ferroptosis‐Boosted Mild‐Temperature Photothermal Therapy

et al. 2021

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Photothermal therapy( PTT) is an extremely promising tumor therapeutic modality.H owever,e xcessive heat inevitably injures normal tissues near tumors,a nd the damage to cancer cells caused by mild hyperthermia is easily repaired by stress-induced heat shock proteins (HSPs). Thus, maximizing the PTT efficiency and minimizing the damage to healthy tissues simultaneously by adopting appropriate therapeutic temperatures is imperative.H erein, an innovative strategy is reported:f erroptosis-boosted mild PTT based on as ingle-atom nanozyme (SAzyme). The Pd SAzyme with atom-economical utilization of catalytic centers exhibits peroxidase (POD) and glutathione oxidase (GSHOx) mimicking activities,a nd photothermal conversion performance,w hich can result in ferroptosis featuring the up-regulation of lipid peroxides (LPO) and reactive oxygen species (ROS). The accumulation of LPO and ROSprovides apowerfulapproach for cleaving HSPs,which enables Pd SAzyme-mediated mildtemperature PTT.

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Near-infrared heptamethine cyanine dye-based nanoscale coordination polymers with intrinsic nucleus-targeting for low temperature photothermal therapy

Cited by 57 publications

References 35 publications

Low-Temperature Photothermal Therapy: Strategies and Applications

Low-Temperature Photothermal Therapy: Strategies and Applications

Metal‐Coordinated Supramolecular Self‐Assemblies for Cancer Theranostics

Single‐Atom Pd Nanozyme for Ferroptosis‐Boosted Mild‐Temperature Photothermal Therapy

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