Near-infrared fluorescent probe based on cyanine scaffold for sensitive detection of uranyl ions in living cells and water samples

Zhang, Yibin; Sun, Lin; Yan, Qing; Qiu, Xianyu; Cheng, Yueting; Wang, Boling; Tan, Xiaoping; Fang, Mingxi; Luck, Rudy L.; Liu, Haiying

doi:10.1016/j.microc.2022.107619

Cited by 20 publications

(6 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Preferential targeting was possible for a number of probes bearing single indolium motifs, such as in 91 , bearing ether substitution on to the meso position. [137] Progression from this to acid derivative substitution in 92 [138] and 93 [139] was observed to result in small changes to the photophysical parameters, including narrow Stokes shifts. [138] In turn, a significant hypsochromic shit and larger Stokes shifts can be observed in 94 .…”

Section: Cyaninesmentioning

confidence: 99%

Mitochondrial Targeting and Imaging with Small Organic Conjugated Fluorophores: A Review

Crawford

Dimitriadi

Bassin

et al. 2022

Chemistry A European J

View full text Add to dashboard Cite

The last decade has seen an increasingly large number of studies reporting on the development of novel small organic conjugated systems for mitochondrial imaging exploiting optical signal transduction pathways. Mitochondria are known to play a critical role in a number of key biological processes, including cellular metabolism. Importantly, irregularities on their working function are nowadays understood to be intimately linked to a range of clinical conditions, highlighting the importance of targeting mitochondria for therapeutic benefits. In this work we carry out an in‐depth evaluation on the progress to date in the field to pave the way for the realization of superior alternatives to those currently existing. The manuscript is structured by commonly used chemical scaffolds and comprehensively covers key aspects factored in design strategies such as synthetic approaches as well as photophysical and biological characterization, to foster collaborative work among organic and physical chemists as well as cell biologists.

show abstract

Section: Cyaninesmentioning

confidence: 99%

Mitochondrial Targeting and Imaging with Small Organic Conjugated Fluorophores: A Review

Crawford

Dimitriadi

Bassin

et al. 2022

Chemistry A European J

View full text Add to dashboard Cite

show abstract

“…In recent years, some elegant detectors have been developed for UO 2 2+ detection using organic ionophores, , peptides, , proteins, , microorganisms, and nanomaterials , as recognition elements. Although these methods have made significant contributions to UO 2 2+ detection, their selectivity remains a great challenge in sensing assays .…”

Section: Introductionmentioning

confidence: 99%

Heavy Metal-Induced Assembly of DNA Network Biosensor from Double-Loop Hairpin Probes for Ultrasensitive Detection of UO₂²⁺ in Water and Soil Samples

Chen,

Wang,

Guo

et al. 2024

Anal. Chem.

View full text Add to dashboard Cite

The uranyl ion (UO2 2+) is the most stable form of uranium, which exhibits high toxicity and bioavailability posing a severe risk to human health. The construction of ultrasensitive, reliable, and robust sensing techniques for UO2 2+ detection in water and soil samples remains a challenge. Herein, a DNA network biosensor was fabricated for UO2 2+ detection using DNAzyme as the heavy metal recognition element and double-loop hairpin probes as DNA assembly materials. UO2 2+-activated specific cleavage of the DNAzyme will liberate the triggered DNA fragment, which can be utilized to launch a double-loop hairpin probe assembly among Hab, Hbc, and Hca. Through multiple cyclic cross-hybridization reactions, hexagonal DNA duplex nanostructures (n[Hab•Hbc•Hca]) were formed. This DNA network sensing system generates a high fluorescence response for UO2 2+ monitoring. The biosensor is ultrasensitive, with a detection limit of 2 pM. This sensing system also displays an excellent selectivity and robustness, enabling the DNA network biosensor to work even in complex water and soil samples with excellent accuracy and reliability. With the advantages of enzyme-free operation, outstanding specificity, and high sensitivity, our proposed DNA network biosensor provides a reliable, simple, and robust method for trace levels of UO2 2+ detection in environmental samples.

show abstract

“…12,13 More crucially, fluorescent probes provide direct observation of dynamic information regarding HOCl in live cells, tissues, and animals with great temporal and spatial resolution combined with high resolution confocal microscopy. 14–17 Towards this end, chemists and biologists have made significant progress in generating highly specific fluorescent probes for visualizing lysosomal HOCl. 18–22 Despite these incredible accomplishments, the majority of the reported HOCl/ClO − probes exhibit poor reactivities, short emission wavelengths, high toxicities, and certain interferences from other ROS/RNS.…”

Section: Introductionmentioning

confidence: 99%

In vivo bioimaging and detection of endogenous hypochlorous acid in lysosome using a near-infrared fluorescent probe

Jiang

Wang

et al. 2023

Anal. Methods

Self Cite

View full text Add to dashboard Cite

show abstract

Near-infrared fluorescent probe based on cyanine scaffold for sensitive detection of uranyl ions in living cells and water samples

Cited by 20 publications

References 33 publications

Mitochondrial Targeting and Imaging with Small Organic Conjugated Fluorophores: A Review

Mitochondrial Targeting and Imaging with Small Organic Conjugated Fluorophores: A Review

Heavy Metal-Induced Assembly of DNA Network Biosensor from Double-Loop Hairpin Probes for Ultrasensitive Detection of UO₂²⁺ in Water and Soil Samples

In vivo bioimaging and detection of endogenous hypochlorous acid in lysosome using a near-infrared fluorescent probe

Contact Info

Product

Resources

About

Near-infrared fluorescent probe based on cyanine scaffold for sensitive detection of uranyl ions in living cells and water samples

Cited by 20 publications

References 33 publications

Mitochondrial Targeting and Imaging with Small Organic Conjugated Fluorophores: A Review

Mitochondrial Targeting and Imaging with Small Organic Conjugated Fluorophores: A Review

Heavy Metal-Induced Assembly of DNA Network Biosensor from Double-Loop Hairpin Probes for Ultrasensitive Detection of UO22+ in Water and Soil Samples

In vivo bioimaging and detection of endogenous hypochlorous acid in lysosome using a near-infrared fluorescent probe

Contact Info

Product

Resources

About

Heavy Metal-Induced Assembly of DNA Network Biosensor from Double-Loop Hairpin Probes for Ultrasensitive Detection of UO₂²⁺ in Water and Soil Samples