Near-Infrared Fluorescent Labeled Peptosome for Application to Cancer Imaging

Tanisaka, Hiroki; Kizaka‐Kondoh, Shinae; Makino, Akihiro; Tanaka, Shotaro; Hiraoka, Masahiro; Kimura, Shunsaku

doi:10.1021/bc7001665

Cited by 112 publications

(97 citation statements)

References 55 publications

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“…[17] demonstrated that the polymerization of sarcosine-NCA could be controlled more readily as compared to regular amino acid NCAs. More recently, Zhang and co-workers found that N-substituted NCAs could be polymerized yielding cyclic polypeptoids with excellent yield in a well-controlled manner [18][19][20][21].…”

Section: Open Accessmentioning

confidence: 99%

Thermal Properties of Aliphatic Polypeptoids

Fetsch

Luxenhofer

2013

Polymers

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A series of polypeptoid homopolymers bearing short (C 1 -C 5 ) side chains of degrees of polymerization of 10-100 are studied with respect to thermal stability, glass transition and melting points. Thermogravimetric analysis of polypeptoids suggests stability to >200 °C. The study of the glass transition temperatures by differential scanning calorimetry revealed two dependencies. On the one hand an extension of the side chain by constant degree of polymerization decrease the glass transition temperatures (T g ) and on the other hand a raise of the degree of polymerization by constant side chain length leads to an increase of the T g to a constant value. Melting points were observed for polypeptoids with a side chain comprising not less than three methyl carbon atoms. X-ray diffraction of polysarcosine and poly(N-ethylglycine) corroborates the observed lack of melting points and thus, their amorphous nature. Diffractograms of the other investigated polypeptoids imply that crystalline domains exist in the polymer powder.

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Section: Open Accessmentioning

confidence: 99%

Thermal Properties of Aliphatic Polypeptoids

Fetsch

Luxenhofer

2013

Polymers

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“…Bioinspired polypeptides and polypeptides containing block copolymers have attracted signicant scientic interest in polymer science over the last few decades due to their potential applications in biomedicine and biotechnology elds such as tissue-engineering scaffolds, 1-3 drug-delivery carriers, biomedical imaging agents, 4 and antibacterial agents. [5][6][7][8][9][10] Poly(g-benzyl-L-glutamate) (PBLG) is one of the most well studied polypeptides which could be easily synthesized by ring-opening polymerization (ROP) of N-carboxyanhydrides (NCA) of amino acids.…”

Section: Introductionmentioning

confidence: 99%

A novel self-assembled hybrid organogel of polypeptide-based block copolymers with inclusion of polypeptide-functionalized graphene

Lei

Shi

et al. 2017

RSC Adv.

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Self-assembled hybrid organogels of polypeptides containing block copolymers with the inclusion of polypeptide-functionalized graphene were designed and elaborately prepared, and showed interesting microstructures as well as enhanced mechanical performances. Firstly, a series of peptide-based triblock copolymers (triBCPs),, with different lengths of PBLG helices, were synthesized and characterized. As the length of the PBLG helices increased, the critical gelation concentration of the BDB triBCPs decreased while the gel-sol transition temperature increased. Moreover, the PBLG covalently modified graphene oxide (GO) sheets were successfully incorporated into the BDB organogels in toluene and hybrid organogels were prepared. In the presence of GO sheets, the minimum gelation concentration of the hybrid organogel was slightly lowered, and the hybrid organogels preserved thermoreversibility. In the hybrid gels, the triBCPs still self-assembled into nanoribbon structures and the functionalized GO sheets were well dispersed in the gel medium, which was obviously observed by transmission electron microscopy. In addition, the inclusion of the functionalized graphene greatly enhanced the mechanical performance of the hybrid gels, which was demonstrated by the significant increase of the moduli and the fracture stress of the hybrid gels compared with the corresponding native gels in the rheology experiments.

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“…However, the strong binding of plasma proteins with ICG and its subsequent rapid clearance by the liver results in binding of ICG to the tumor only for a short duration after administration; thus, the use of ICG for tumor imaging applications is limited [17]. A potential approach to overcoming this disadvantage is delivering ICG in a nanocarrier that can provide increased stability and protection from nonspecific plasma protein binding and offer enhanced circulation time [18][19][20]. A novel nanocarrier, ICG-lactosome [21], which is a molecular assembly composed of hydrophobic poly(L-lactic acid) (PLLA) and hydrophilic poly(sarcosine) (PSar) amphiphilic block polydespsipeptide including ICG labeled PLLA in the hydrophobic inner core, provides good tumor imaging without accumulation to the liver.…”

Section: Introductionmentioning

confidence: 99%

Intraoperative Near-infrared Fluorescence Imaging with Novel Indocyanine Green-Loaded Nanocarrier for Spinal Metastasis: A Preliminary Animal Study

Funayama¹,

Sakane²,

Abe³

et al. 2012

TOBEJ

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Abstract:Marginal resection during resection of a spinal metastasis is frequently difficult because of the presence of important tissues such as the aorta, vena cava, and dura mater, including the spinal cord adjacent to the vertebral body. Thus, there is an urgent need for novel intraoperative imaging modalities with the ability to clearly identify bone metastasis. We have proposed a novel nanocarrier loaded with indocyanine green (ICG) (ICG-lactosome) with tumor selectivity attributable to its enhanced permeation and retention (EPR) effect. We studied its feasibility in intraoperative near-infrared (NIR) fluorescence diagnosis with ICG-lactosome for imaging spinal metastasis. A rat model of subcutaneous mammary tumor and a rat model of spinal metastasis of breast cancer were used. Fluorescence emitted by the subcutaneous tumors and the spinal metastasis were clearly detected for at least 24 h. Moreover, imaging of the dissected spine revealed clear fluorescence emitted by the metastatic lesion in the L6 vertebra while the normal bone lacked fluorescence. This study was the first report on NIR fluorescence imaging of spinal metastasis in vivo. NIR fluorescence imaging with ICG-lactosome could be an effective intraoperative imaging modality for detecting spinal metastasis.

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Near-Infrared Fluorescent Labeled Peptosome for Application to Cancer Imaging

Cited by 112 publications

References 55 publications

Thermal Properties of Aliphatic Polypeptoids

Thermal Properties of Aliphatic Polypeptoids

A novel self-assembled hybrid organogel of polypeptide-based block copolymers with inclusion of polypeptide-functionalized graphene

Intraoperative Near-infrared Fluorescence Imaging with Novel Indocyanine Green-Loaded Nanocarrier for Spinal Metastasis: A Preliminary Animal Study

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