Near-infrared fluorescent chemodosimeter for real-time <i>in vivo</i> evaluation of H<sub>2</sub>S-release efficiency of prodrug

Yao, Xufeng; Liu, Wangwang; Zhu, Wenchao; Tiemuer, Aliya; Zhou, Fangyuan; Yang, Shikui; Yu, Hui; Qian, Xinming; Liu, Yi

doi:10.1039/d0cc02814b

Cited by 23 publications

(7 citation statements)

References 52 publications

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“…To increase the nanoprobe's cancer targetability via the EPR effect, c(RGDyK) peptide connected RGD–nanoprobe was intravenously injected, confirming that PA 532nm and PA 700nm signals were successfully recorded in the brain tissue and depended on the concentration of H 2 S. Later, a similar fluorescent probe NRh-N 3 was developed by Liu et al to efficiently evaluate H 2 S release from the prodrug in vitro and in vivo . 215…”

Section: Nir Fluorescent Probes For Small Moleculesmentioning

confidence: 99%

Activity-based NIR fluorescent probes based on the versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook

et al. 2022

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Section: Nir Fluorescent Probes For Small Moleculesmentioning

confidence: 99%

Activity-based NIR fluorescent probes based on the versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook

et al. 2022

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“…The current data analysis types have different degrees of error, which is because the parameters set by different data analysis types have many differences. Therefore, in the process of solving specific problems, the differences of parameters are very different, which will affect the final data operation results [ 21 ]. Intuitionistic fuzzy information algorithm is mainly used to quantitatively analyze the targeted data of different sports public service efficiency and evaluation in solving the problem of sports public service efficiency evaluation.…”

Section: Methodsmentioning

confidence: 99%

Intelligent Evaluation of Public Sports Service Based on Intuitionistic Fuzzy Set Theory

2022

Computational Intelligence and Neuroscience

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At this stage, in the research process of sports public service efficiency evaluation and analysis, due to the use of accurate data analysis methods, there are problems of low evaluation reliability and low analysis speed. Based on this, this paper studies the application of an information strategy based on the intuitionistic fuzzy data matching method in the evaluation and analysis of sports public service efficiency. The efficiency evaluation and analysis model of sports public service based on the intuitive fuzzy information algorithm is established. According to the characteristics of different types of sports public service, different types of data analysis methods are used to evaluate the efficiency, and the optimization of the efficiency analysis model of sports public service is realized according to the service demand and data type of different sports events. Finally, an experiment is designed to quantitatively evaluate the accuracy, stability, and reliability of the sports public service analysis model. The results show that the efficiency intelligent evaluation and analysis model based on the intuitive fuzzy information algorithm can effectively select the optimal sports public service evaluation countermeasures and rules according to the characteristics and data types of different sports events, realize the multi-dimensional accuracy classification of different types of sports events, and effectively improve the reliability of sports public service efficiency evaluation.

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“…NRh-NH 2 was synthesized according to the method reported in the literature 29 . Please refer to the supporting information for detailed synthesis steps ( Figure S1 ).…”

Section: Methodsmentioning

confidence: 99%

γ-Glutamyl transpeptidase-activatable near-infrared nanoassembly for tumor fluorescence imaging-guided photothermal therapy

Zhou¹,

Yang²,

Zhao³

et al. 2021

Theranostics

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Rationale: Precise treatment of tumors is attracting increasing attention. Molecular probes simultaneously demonstrating the diagnostic signal and pharmacological effect in response to tumor microenvironment are highly desired. γ-glutamyl transpeptidase (GGT) is a biomarker with significantly up-regulated expression in the tumor area. We developed a GGT responsive near-infrared (NIR) nanoassembly for tumor-specific fluorescence imaging-guided photothermal therapy. Methods: The GGT responsive NIR probe was constructed by conjugating GGT-specific substrate γ-glutamic acid (γ-Glu) with cyanine fluorophore (NRh-NH 2 ) via amide reaction. The resulting NRh-G spontaneously assembled into nanoparticles (NRh-G-NPs) around 50 nm. The NPs were characterized and the properties evaluated in the presence or absence of GGT. Subsequently, we studied fluorescence imaging and photothermal therapy of NRh-G-NPs in vitro and in vivo . Results: NRh-G-NPs, upon specific reaction with GGT, turned into NRh-NH 2 -NPs, showing a ~180-fold fluorescence enhancement and excellent photothermal effect recovery. NRh-G-NPs could selectively light up U87MG tumor cells while their fluorescence was weak in L02 human normal liver cells. The NPs also showed excellent tumor cell ablation upon laser irradiation. After intravenous injection into tumor-bearing mice, NRh-G-NPs could arrive in the tumor area and specifically light up the tumor. Following laser irradiation, the tumor could be completely erased with no tumor reoccurrence for up to 40 days. Conclusions: NRh-G-NPs were specifically responsive to GGT overexpressed in U87MG tumor cells and selectively lit up the tumor for imaging-guided therapy. Besides, the recovery of photothermal property in the tumor area could improve cancer therapy precision and decreased side effects in normal tissues.

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Near-infrared fluorescent chemodosimeter for real-time in vivo evaluation of H₂S-release efficiency of prodrug

Abstract: A promising platform for evaluating H2S-release in pharmaceutical development, and enabling a great method for monitoring H2S in future clinical medicine.

Cited by 23 publications

References 52 publications

Activity-based NIR fluorescent probes based on the versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook

Activity-based NIR fluorescent probes based on the versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook

Intelligent Evaluation of Public Sports Service Based on Intuitionistic Fuzzy Set Theory

γ-Glutamyl transpeptidase-activatable near-infrared nanoassembly for tumor fluorescence imaging-guided photothermal therapy

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Near-infrared fluorescent chemodosimeter for real-time in vivo evaluation of H2S-release efficiency of prodrug

Abstract: A promising platform for evaluating H2S-release in pharmaceutical development, and enabling a great method for monitoring H2S in future clinical medicine.

Cited by 23 publications

References 52 publications

Activity-based NIR fluorescent probes based on the versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook

Activity-based NIR fluorescent probes based on the versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook

Intelligent Evaluation of Public Sports Service Based on Intuitionistic Fuzzy Set Theory

γ-Glutamyl transpeptidase-activatable near-infrared nanoassembly for tumor fluorescence imaging-guided photothermal therapy

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Product

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Near-infrared fluorescent chemodosimeter for real-time in vivo evaluation of H₂S-release efficiency of prodrug