Near-infrared fluorescent carbon dots encapsulated liposomes as multifunctional nano-carrier and tracer of the anticancer agent cinobufagin in vivo and in vitro

Ren, Wei; Chen, Shiqing; Liao, Yuyang; Li, Shumu; Ge, Jiechao; Tao, Fengyun; Huo, Qing; Zhang, Yangyang; Zhao, Zhenwen

doi:10.1016/j.colsurfb.2018.11.041

Cited by 43 publications

(33 citation statements)

References 38 publications

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“…The prepared CDs appear spherical and are highly water soluble and good dispersion, with a size ranging from 5 to 8 nm (Figure 1A). The UV‐vis absorption spectrum of CDs showed that a broad absorption peak exists at 440 nm (Figure 1B), which was assigned to the n‐π* transition from the surface groups and was consistent with our previous reports [21–22] . The photoluminescence (PL) emission spectrum of the CDs had a wide range from 550 to 700 nm with a peak at 608 nm, exhibiting the excitation‐independent PL behavior, which was related to the surface states/groups of the CDs (Figure 1B) [20] .…”

Section: Resultssupporting

confidence: 89%

“…Simultaneously, we discovered that N and S elements doping is an effective approach to obtain red emissive CDs and the electrostatic attraction coupled with π‐π interactions between the oppositely charged CDs and surfactant molecules could form CDs‐surfactant complexes [20] . Further, we successfully constructed a multifunctional nano‐carrier system using red emissive CDs encapsulated liposomes with integrated therapeutic and imaging functions [21] . However, more extensive and deep‐going explorations of the applications of red emissive CDs are still needed.…”

Section: Introductionmentioning

confidence: 99%

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Red Emissive Carbon Dots Prepared from Polymers as an Efficient Nanocarrier for Coptisine Delivery in vivo and in vitro

Ren

Nan

et al. 2020

ChemMedChem

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Negatively charged fluorescent carbon dots (CDs, Em=608 nm) were hydrothermally prepared from thiophene phenylpropionic acid polymers and then successfully loaded with the positively charged anticancer cargo coptisine, which suffers from poor bioavailability. The formed CD‐coptisine complexes were thoroughly characterized by particle size, morphology, drug loading efficiency, drug release, cellular uptake and cellular toxicity in vitro and antitumor activities in vivo. In this nano‐carrier system, red emissive CDs possess multiple advantages as follows: 1) high drug loading efficiency (>96 %); 2) sustained drug release; 3) enhanced drug efficacy towards cancer cells; 4) EPR effect; 5) drug release tracing with near‐infrared imaging. These properties indicated that red emissive CDs prepared from polymers could be used as a novel drug delivery system with integrated therapeutic and imaging functions in cancer therapy, which are expected to have great potential in future clinical applications.

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Section: Resultssupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Red Emissive Carbon Dots Prepared from Polymers as an Efficient Nanocarrier for Coptisine Delivery in vivo and in vitro

Ren

Nan

et al. 2020

ChemMedChem

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“…Interestingly, the CNDs can freely penetrate the blood-brain barrier and reach the brain in only 5 min, while in 15 min the highest fluorescence could be observed only from the glioma tissue, with the normal brain tissue to scarcely exhibit fluorescence. Similarly, Ren et al produced red emissive CNDs from the hydrothermal treatment of phenylpropionic acid polymers [99]. Next, they prepared liposomes loaded with the CNDs, and authors demonstrated that the CNDs loaded liposomes are more efficient for the MCF-7 tumor imaging in nude mice, compared with plain CNDs (Figure 4).…”

Section: In Vivo Imaging Applicationsmentioning

confidence: 98%

Bioimaging Applications of Carbon Nanodots: A Review

Kasouni

Chatzimitakos

Stalikas

2019

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Carbon nanodots (CNDs) is the newest member of carbon-based nanomaterials and one of the most promising for the development of new, advanced applications. Owing to their unique and unparalleled physicochemical and photoluminescent properties, they are considered to be a rising star among nanomaterials. During the last decade, many applications have been developed based on CNDs. Among others, they have been used as bioimaging agents to label cells and tissues. In this review, we will discuss the advancements in the applications of CNDs in in the field of imaging, in all types of organisms (i.e., prokaryotes, eukaryotes, and animals). Selective imaging of one type of cells over another, imaging of (bio)molecules inside cells and tumor-targeting imaging are some of the studies that will be discussed hereafter. We hope that this review will assist researchers with obtaining a holistic view of the developed applications and hit on new ideas so that more advanced applications can be developed in the near future.

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“…It has shown significant efficacy in the treatment of various malignant tumors, especially lung, liver, and pancreatic cancers, when used alone or in combination with other chemotherapy drugs (Qi et al, 2011). However, due to the poor water solubility, short circulating half-life, and low bioavailability of Cino, improving its anticancer efficacy is an urgent clinical problem that needs to be solved (Ren et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…In order to improve the therapeutic efficacy and enhanced solubility of the anticancer agent, a stimuli-responsive and targeting molecule-modified organic nanomedicine was developed. The biodegradable PDA nanomedicine was firstly synthesized via a classical Stöber method (by the reduction of dopamine hydrochloride to PDA in an aqueous alkaline solution) (Ren et al, 2019). Subsequently, the surface of the PDA nanomedicine was modified by the targeting molecule FA through the covalent coupling reaction of amino and carboxyl groups in the presence of EDC and NHS.…”

Section: Introductionmentioning

confidence: 99%

Cinobufagin-Loaded and Folic Acid-Modified Polydopamine Nanomedicine Combined With Photothermal Therapy for the Treatment of Lung Cancer

Zhang

Deng

et al. 2021

Front. Chem.

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Cinobufagin is used as a traditional Chinese medicine for cancer therapy. However, it has some disadvantages, such as poor water solubility, short circulating half-life, and low bioavailability. In the present study, a targeted delivery and smart responsive polydopamine (PDA)-based nanomedicine for delivering cinobufagin was rationally designed to improve the anticancer efficacy of the compound for the treatment of lung cancer. The modification of the nanomedicine using folic acid first mediated tumor targeting via the interaction between folic acid and its receptors on tumor cells. After lysosomes escape, the PDA nanomedicine was triggered by the low pH and released its cargo into the tumor microenvironment. The nanomedicine had a better therapeutic effect against lung cancer when used in combination with photothermal therapy. Compared with other nanomedicines used with photothermal therapy, this nanocarrier was not only sensitive to biologically low pH levels for on-demand drug release, but was also biodegradable, breaking down into biocompatible terminal products. Therefore, the proposed drug delivery system with targeted delivery and smart release demonstrated potential as a multifunctional nanoplatform that can enhance the bioavailability and reduce the side effects of chemotherapeutic agents.

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Near-infrared fluorescent carbon dots encapsulated liposomes as multifunctional nano-carrier and tracer of the anticancer agent cinobufagin in vivo and in vitro

Cited by 43 publications

References 38 publications

Red Emissive Carbon Dots Prepared from Polymers as an Efficient Nanocarrier for Coptisine Delivery in vivo and in vitro

Red Emissive Carbon Dots Prepared from Polymers as an Efficient Nanocarrier for Coptisine Delivery in vivo and in vitro

Bioimaging Applications of Carbon Nanodots: A Review

Cinobufagin-Loaded and Folic Acid-Modified Polydopamine Nanomedicine Combined With Photothermal Therapy for the Treatment of Lung Cancer

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