Near-infrared excited cooperative upconversion in luminescent Ytterbium(ΙΙΙ) bioprobes as light-responsive theranostic agents

Dasari, Srikanth; Singh, Swati; Kumar, Priyaranjan; Sivakumar, S.; Patra, Ashis K.

doi:10.1016/j.ejmech.2018.12.010

Cited by 35 publications

(33 citation statements)

References 112 publications

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“…The K app equals 3.9 10 7 M −1 , indicating high affinity to CT-DNA, most probably through a DNA intercalative mode. A similar value of 1.2 10 7 M −1 was found for a [Pt(pydppz)Cl]Cl (pydppz = 6-(2-pyridyl)-dipyrido-[3,2-a:2 ,3 -c]phenazine) complex[33], while lower values of ∼1.3-6.0 10 6 M −1 have often been reported for other lanthanide dppz complexes[20,25,29].…”

supporting

confidence: 77%

“…(L = 3,5-heptanedione) complex has been reported, showing strong NIR luminescence and the incorporation of such complexes in poly(methyl methacrylate) (PMMA) thin films was studied for potential biological applications [19]. Ytterbium(III) complexes, such as [Yb(dppz)(DMF) 2 Cl 3 ] and [Yb(dppz)(ttfa) 3 ] (Httfa = 4,4,4-trifluoro-1-(2-thienyl)-1,3-butanedione) have been designed as NIR bioimaging probes using cooperative upconversion luminescence for theranostic application in the biological phototherapeutic window [20]. Another feature of polypyridyl ligands such as dppz is their ability to interact with DNA tracts [21], rendering them perfect candidates as NIR luminescent probes for cellular imaging and diagnostics, when combined with specific lanthanides.…”

Section: Introductionmentioning

confidence: 99%

“…Due to solvent quenching, a drop in the emission intensity is clearly observed. The apparent binding constant K app of the [Nd(NO 3 ) 3 (dppz) 2 ] complex to the CT-DNA was determined using the equation K EthB [EthB] = K app C 50 , where K EthB is the binding constant of EthB (1.0 10 7 M −1 , [EthB] is the EthB concentration (1.27 mM) and C 50 is the concentration of the [Nd(NO 3 ) 3 (dppz) 2 ] complex at 50% reduction of the fluorescence intensity of the EthB (323.6 µM; based on the Stern-Volmer plot of I/I 0 vs [complex]; see Supplementary Materials)[20,32]. The K app equals 3.9 10 7 M −1 , indicating high affinity to CT-DNA, most probably through a DNA intercalative mode.…”

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confidence: 99%

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DNA Intercalating Near-Infrared Luminescent Lanthanide Complexes Containing Dipyrido[3,2-a:2′,3′-c]phenazine (dppz) Ligands: Synthesis, Crystal Structures, Stability, Luminescence Properties and CT-DNA Interaction

et al. 2020

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In order to create near-infrared (NIR) luminescent lanthanide complexes suitable for DNA-interaction, novel lanthanide dppz complexes with general formula [Ln(NO3)3(dppz)2] (Ln = Nd3+, Er3+ and Yb3+; dppz = dipyrido[3,2-a:2′,3′-c]phenazine) were synthesized, characterized and their luminescence properties were investigated. In addition, analogous compounds with other lanthanide ions (Ln = Ce3+, Pr3+, Sm3+, Eu3+, Tb3+, Dy3+, Ho3+, Tm3+, Lu3+) were prepared. All complexes were characterized by IR spectroscopy and elemental analysis. Single-crystal X-ray diffraction analysis of the complexes (Ln = La3+, Ce3+, Pr3+, Nd3+, Eu3+, Er3+, Yb3+, Lu3+) showed that the lanthanide’s first coordination sphere can be described as a bicapped dodecahedron, made up of two bidentate dppz ligands and three bidentate-coordinating nitrate anions. Efficient energy transfer was observed from the dppz ligand to the lanthanide ion (Nd3+, Er3+ and Yb3+), while relatively high luminescence lifetimes were detected for these complexes. In their excitation spectra, the maximum of the strong broad band is located at around 385 nm and this wavelength was further used for excitation of the chosen complexes. In their emission spectra, the following characteristic NIR emission peaks were observed: for a) Nd3+: 4F3/2 → 4I9/2 (870.8 nm), 4F3/2 → 4I11/2 (1052.7 nm) and 4F3/2 → 4I13/2 (1334.5 nm); b) Er3+: 4I13/2 → 4I15/2 (1529.0 nm) c) Yb3+: 2F5/2 → 2F7/2 (977.6 nm). While its low triplet energy level is ideally suited for efficient sensitization of Nd3+ and Er3+, the dppz ligand is considered not favorable as a sensitizer for most of the visible emitting lanthanide ions, due to its low-lying triplet level, which is too low for the accepting levels of most visible emitting lanthanides. Furthermore, the DNA intercalation ability of the [Nd(NO3)3(dppz)2] complex with calf thymus DNA (CT-DNA) was confirmed using fluorescence spectroscopy.

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confidence: 77%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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DNA Intercalating Near-Infrared Luminescent Lanthanide Complexes Containing Dipyrido[3,2-a:2′,3′-c]phenazine (dppz) Ligands: Synthesis, Crystal Structures, Stability, Luminescence Properties and CT-DNA Interaction

et al. 2020

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Section: Introductionmentioning

confidence: 99%

“…[10] For instance, lanthanide (with special emphasis on gadolinium) chelates have been developed as potential theragnostic agents for the precise delivery of anticancer agents while monitoring the in vivo biological effects. [10][11][12][13] Although reports on the anticancer activity are still scarce, lanthanide complexes have also proven their therapeutic potential as effective cytotoxic agents and noncovalent DNA interactors. [14] In this context, we report the synthesis and structural investigation of four new complexes of Sm(III), Eu(III), Gd(III), and Tb(III) with 5-hydroxyflavone and 1,10-phenanthroline.…”

mentioning

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New heteroleptic lanthanide complexes as multimodal drugs: Cytotoxicity studies, apoptosis, cell cycle analysis, DNA interactions, and protein binding

Arbănași

Musat

Mihăilă³

et al. 2020

Applied Organom Chemis

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We report herein the synthesis and characterization of four new heteroleptic complexes of Sm(III), Eu(III), Gd(III), and Tb(III) with the natural flavonoid 5-hydroxyflavone (primuletin) and 1,10-phenanthroline. According to the physicochemical characterization, the mononuclear complexes correspond to the general formula [Ln(OH) 2 L 1 L 2 ]ÁnH 2 O, where L 1 = C 15 H 9 O 3 (deprotonated 5-hydroxyflavone) and L 2 = C 12 H 8 N 2 (1,10-phenanthroline), Ln is the lanthanide cation, and n = 4 for Sm(III), 3.5 for Eu(III), 2 for Gd(III), and 3 for Tb(III). A six-coordinated distorted octahedron geometry was proposed for the complexes, and density functional theory (DFT) studies were used to calculate their optimized geometry. Cytotoxicity was studied using MTS assay on cervical, colorectal, colon, breast, and ovarian adenocarcinoma cell lines. Flow cytometry data were consistent with apoptotic cell death and disruption of the cell cycle in cervical and colon cancer cells. As a means to investigate the mechanism underlying the cytotoxic effects, the abilities of the complexes to interact with calf thymus DNA, human serum albumin, and transferrin have also been assessed. According to experimental and computational studies, the four lanthanide complexes act as DNA intercalators and bind strongly to serum proteins.

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Luminescent Lanthanide Probes for Inorganic and Organic Phosphates

Martinon

Pierre

2022

Chemistry An Asian Journal

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Inorganic and organic phosphates‐including orthophosphate, nucleotides, and DNA‐are some of the most fundamental anions in cellular biology, regulating numerous processes of both medical and environmental significance. The characteristic long lifetimes of emitting lanthanides, including the brighter europium(III) and terbium(III), make them ideally suited for the development of molecular probes for the detection of phosphates directly in complex aqueous media. Moreover, given their high oxophilicity and the exquisite sensitivity of their quantum yields to their hydration number, those luminescent lanthanides are perfect for the detection of phosphates. Herein we discuss the principles that have guided the recent developments of molecular probes selective for inorganic or organic phosphates and how these lanthanide complexes facilitate the study of numerous biological processes.

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Near-infrared excited cooperative upconversion in luminescent Ytterbium(ΙΙΙ) bioprobes as light-responsive theranostic agents

Cited by 35 publications

References 112 publications

DNA Intercalating Near-Infrared Luminescent Lanthanide Complexes Containing Dipyrido[3,2-a:2′,3′-c]phenazine (dppz) Ligands: Synthesis, Crystal Structures, Stability, Luminescence Properties and CT-DNA Interaction

DNA Intercalating Near-Infrared Luminescent Lanthanide Complexes Containing Dipyrido[3,2-a:2′,3′-c]phenazine (dppz) Ligands: Synthesis, Crystal Structures, Stability, Luminescence Properties and CT-DNA Interaction

New heteroleptic lanthanide complexes as multimodal drugs: Cytotoxicity studies, apoptosis, cell cycle analysis, DNA interactions, and protein binding

Luminescent Lanthanide Probes for Inorganic and Organic Phosphates

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