Near infrared-emitting persistent luminescent nanoparticles for Hepatocellular Carcinoma imaging and luminescence-guided surgery

Ai, Ting; Shang, Wenting; H, Yan; Zeng, Chaoting; Wang, Kun; Gao, Yuan; Guan, Tianwang; Fang, Chihua; Tian, Jie

doi:10.1016/j.biomaterials.2018.01.031

Cited by 65 publications

(38 citation statements)

References 42 publications

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“…Reproduced with permission. [234] They developed a CT/luminescence contrast agent, termed ZnGa 2 O 4 :Cr 0.004 , for imaging of hepatocellular carcinoma and IGS. www.advmat.de www.advancedsciencenews.com penile carcinoma, even in robotic-assisted surgery.…”

Section: Pet/spect/ct-based Multimodal Imagingmentioning

confidence: 99%

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

et al. 2019

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Surgical resection is the primary and most effective treatment for most patients with solid tumors. However, patients suffer from postoperative recurrence and metastasis. In the past years, emerging nanotechnology has led the way to minimally invasive, precision and intelligent oncological surgery after the rapid development of minimally invasive surgical technology. Advanced nanotechnology in the construction of nanomaterials (NMs) for precision imaging-guided surgery (IGS) as well as surgery-assisted synergistic therapy is summarized, thereby unlocking the advantages of nanotechnology in multimodal IGS-assisted precision synergistic cancer therapy. First, mechanisms and principles of NMs to surgical targets are briefly introduced. Multimodal imaging based on molecular imaging technologies provides a practical method to achieve intraoperative visualization with high resolution and deep tissue penetration. Moreover, multifunctional NMs synergize surgery with adjuvant therapy (e.g., chemotherapy, immunotherapy, phototherapy) to eliminate residual lesions. Finally, key issues in the development of ideal theranostic NMs associated with surgical applications and challenges of clinical transformation are discussed to push forward further development of NMs for multimodal IGS-assisted precision synergistic cancer therapy.

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Section: Pet/spect/ct-based Multimodal Imagingmentioning

confidence: 99%

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

et al. 2019

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“…Imaging-guided surgery can effectively improve the accuracy and safety of surgery and reduce excessive resection of the non-lesioned tissue. 101 In 2019, Ding et al…”

Section: Application Of Vplnps In Biomedicinementioning

confidence: 99%

Electronic structure engineering and biomedical applications of low energy-excited persistent luminescence nanoparticles

Lin

et al. 2020

Nanoscale Adv.

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“…6 Therefore, a number of strategies using nanoparticles such as Nano-structured lipid carrier (NLC), which is called the second generation lipid nanoparticles have been applied in the field of cancer therapy. 7,8 By adding liquid lipids to solid lipids can delay drug leakage and increase drug entrapment efficiency and drug loading. 9 The NLC is composed of a blend of the solid lipid and the liquid lipid leading to a crystal structure with more imperfections and therefore with more room for drug accommodation especially for hydrophobic drugs.…”

Section: Introductionmentioning

confidence: 99%

<p>Formulation, Preparation and Evaluation of Nanostructured Lipid Carrier Containing Naringin and Coix Seed Oil for Anti-Tumor Application Based on “Unification of Medicines and Excipients”</p>

Zhu¹,

Huang²,

Zhang³

et al. 2020

DDDT

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Background: "Unification of medicines and excipients" is the special principle which means fatty oil with pharmacodynamic activity derived from traditional Chinese medicine are taken as liquid lipids in perparation for dual-drug delivery, which improve the treatment effect and reduce unnecessary excipients. Purpose: The aim of this study was to prepare a nanostructured lipid carrier (NLC) with naringin (NG) containing coix seed oil (CSO) as liquid lipid based on the theory (NCNLC) in order to achieve synergistic antitumor activity against hepatocellular carcinoma. Methods: We developed NCNLCs using ultrasonic melt-emulsification method. The antitumor effect in vivo/in vitro and drug release ability were compared to NLC prepared with conventional liquid lipids: neodecanoate triglycerides (NDNLC) and oleic acid (NONLC). Results: Transmission electron microscopy showed that NCNLCs had a well-defined spherical shape, small size, and narrow polydispersity index. Importantly, the release of drugs from NDNLCs and NONLCs was slower than NCNLCs. In the cell study, the result showed a significantly greater antiproliferative effect towards HepG2 cells, and the half-maximal inhibitory concentration of NCNLCs was 3.24-fold, 1.70-fold and 1.52-fold lower to that of free drug, NDNLCs and NONLCs, respectively. Moreover, NCNLCs significantly induced HepG2 cells apoptosis by being 2.12-fold and 9.28-fold higher to that of NDNLCs and NONLCs, respectively. In the study of antitumor efficacy in vivo, the synergistic effect of NCNLCs formulation showed markedly enhanced antitumor efficacy in a xenograft model of liver cancer. Conclusion: The advantages of "unification of medicines and excipients" in formulation characters, drug release and synergistic antitumor effect provide a new idea for the application of the fatty oil of traditional Chinese medicine in the nano-drug delivery for cancer therapy.

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Near infrared-emitting persistent luminescent nanoparticles for Hepatocellular Carcinoma imaging and luminescence-guided surgery

Cited by 65 publications

References 42 publications

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

Electronic structure engineering and biomedical applications of low energy-excited persistent luminescence nanoparticles

<p>Formulation, Preparation and Evaluation of Nanostructured Lipid Carrier Containing Naringin and Coix Seed Oil for Anti-Tumor Application Based on “Unification of Medicines and Excipients”</p>

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