Near‐Infrared‐Emitting Boron‐Difluoride‐Curcuminoid‐Based Polymers Exhibiting Thermally Activated Delayed Fluorescence as Biological Imaging Probes

Paisley, Nathan R.; Halldorson, Sarah V.; Tran, Michael V.; Gupta, Rupsa; Kamal, Saied; Algar, W. Russ; Hudson, Zachary M.

doi:10.1002/anie.202103965

Cited by 66 publications

(71 citation statements)

References 53 publications

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“…Strikingly, by virtue of the tailorable synthesis, low-cost input, favorable photophysical features (e.g., long-lived emissive feature), and excellent biocompatibilities (e.g., metal-free molecular structure), the purely organic TADF materials have shown fascinating appeal in the field of biomedicine. [12][13][14][15][16][17] Up to now, substantial contributions have been made to develop TADF materials for biomedical applications. First, as typical metal-free luminophores, TADF emitters could be utilized for conventional fluorescence imaging in different biological systems.…”

Section: Introductionmentioning

confidence: 99%

Thermally Activated Delayed Fluorescence Material: An Emerging Class of Metal‐Free Luminophores for Biomedical Applications

et al. 2021

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The development of simple, efficient, and biocompatible organic luminescent molecules is of great significance to the clinical transformation of biomaterials. In recent years, purely organic thermally activated delayed fluorescence (TADF) materials with an extremely small single-triplet energy gap (𝚫E ST ) have been considered as the most promising new-generation electroluminescence emitters, which is an enormous breakthrough in organic optoelectronics. By merits of the unique photophysical properties, high structure flexibility, and reduced health risks, such metal-free TADF luminophores have attracted tremendous attention in biomedical fields, including conventional fluorescence imaging, time-resolved imaging and sensing, and photodynamic therapy. However, there is currently no systematic summary of the TADF materials for biomedical applications, which is presented in this review. Besides a brief introduction of the major developments of TADF material, the typical TADF mechanisms and fundamental principles on design strategies of TADF molecules and nanomaterials are subsequently described. Importantly, a specific emphasis is placed on the discussion of TADF materials for various biomedical applications. Finally, the authors make a forecast of the remaining challenges and future developments. This review provides insightful perspectives and clear prospects towards the rapid development of TADF materials in biomedicine, which will be highly valuable to exploit new luminescent materials.

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Section: Introductionmentioning

confidence: 99%

Thermally Activated Delayed Fluorescence Material: An Emerging Class of Metal‐Free Luminophores for Biomedical Applications

et al. 2021

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“…42 Furthermore, the red-shifted and delayed emission can be used for time-resolved bio-imaging applications in which the delayed emission remains present after the cell autofluorescence has died out. [43][44][45]…”

Section: Resultsmentioning

confidence: 99%

Dominant dimer emission provides colour stability for red thermally activated delayed fluorescence emitter

et al. 2022

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“…In general, well-defined AIE polymers have shown their great potential in biomedical applications, in particular in nano-assemblies built for fluorescent probes, bioimaging and drug delivery [ 109 , 110 , 111 , 112 , 113 , 114 ]. Single-fluorophore polymers provide a unique strategy to manipulate molecular fluorescence through precision macromolecular engineering.…”

Section: Discussionmentioning

confidence: 99%

Controlling Molecular Aggregation-Induced Emission by Controlled Polymerization

Bao

2021

Molecules

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In last twenty years, the significant development of AIE materials has been witnessed. A number of small molecules, polymers and composites with AIE activity have been synthesized, with some of these exhibiting great potential in optoelectronics and biomedical applications. Compared to AIE small molecules, macromolecular systems—especially well-defined AIE polymers—have been studied relatively less. Controlled polymerization methods provide the efficient synthesis of well-defined AIE polymers with varied monomers, tunable chain lengths and narrow dispersity. In particular, the preparation of single-fluorophore polymers through AIE molecule-initiated polymerization enables the systematic investigation of the structure–property relationships of AIE polymeric systems. Here, the main polymerization techniques involved in these polymers are summarized and the key parameters that affect their photophysical properties are analyzed. The author endeavored to collect meaningful information from the descriptions of AIE polymer systems in the literature, to find connections by comparing different representative examples, and hopes eventually to provide a set of general guidelines for AIE polymer design, along with personal perspectives on the direction of future research.

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Near‐Infrared‐Emitting Boron‐Difluoride‐Curcuminoid‐Based Polymers Exhibiting Thermally Activated Delayed Fluorescence as Biological Imaging Probes

Cited by 66 publications

References 53 publications

Thermally Activated Delayed Fluorescence Material: An Emerging Class of Metal‐Free Luminophores for Biomedical Applications

Thermally Activated Delayed Fluorescence Material: An Emerging Class of Metal‐Free Luminophores for Biomedical Applications

Dominant dimer emission provides colour stability for red thermally activated delayed fluorescence emitter

Controlling Molecular Aggregation-Induced Emission by Controlled Polymerization

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