Near-Infrared Dyes: Towards Broad-Spectrum Antivirals

Mariewskaya, Kseniya A.; Krasilnikov, Maxim S; Korshun, Vladimir A.; Ustinov, A. V.; Alferova, Vera A.

doi:10.3390/ijms24010188

Cited by 2 publications

(2 citation statements)

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“…Efforts are being made to develop photosensitizers that exhibit antiviral actions more effectively by targeting the envelope lipids of viruses [ 120 ]. For the purpose of anti-microbial infections, photosensitizers that are activatable by near-infrared light, which penetrates deep into tissue, are being developed and have become another approach to the use of 1 O 2 [ 125 ].…”

Section: Cellular Responses To 1 Omentioning

confidence: 99%

Biological Action of Singlet Molecular Oxygen from the Standpoint of Cell Signaling, Injury and Death

2023

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Energy transfer to ground state triplet molecular oxygen results in the generation of singlet molecular oxygen (1O2), which has potent oxidizing ability. Irradiation of light, notably ultraviolet A, to a photosensitizing molecule results in the generation of 1O2, which is thought to play a role in causing skin damage and aging. It should also be noted that 1O2 is a dominant tumoricidal component that is generated during the photodynamic therapy (PDT). While type II photodynamic action generates not only 1O2 but also other reactive species, endoperoxides release pure 1O2 upon mild exposure to heat and, hence, are considered to be beneficial compounds for research purposes. Concerning target molecules, 1O2 preferentially reacts with unsaturated fatty acids to produce lipid peroxidation. Enzymes that contain a reactive cysteine group at the catalytic center are vulnerable to 1O2 exposure. Guanine base in nucleic acids is also susceptible to oxidative modification, and cells carrying DNA with oxidized guanine units may experience mutations. Since 1O2 is produced in various physiological reactions in addition to photodynamic reactions, overcoming technical challenges related to its detection and methods used for its generation would allow its potential functions in biological systems to be better understood.

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Section: Cellular Responses To 1 Omentioning

confidence: 99%

Biological Action of Singlet Molecular Oxygen from the Standpoint of Cell Signaling, Injury and Death

2023

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“…In the absence of virus systems for reparation, the photodamage of the lipid envelope causes a dramatic reduction in the infectivity of virions due to the inactivation of viral fusion. Among the photosensitizers, compounds with absorption in the infrared region are of particular interest in the search for new broad-spectrum antivirals due to their substantially higher tissue transparency for the radiation of this spectrum [465].…”

Section: Disrupting Agents 411 Photosensitizing Antiviralsmentioning

confidence: 99%

Lipid-Centric Approaches in Combating Infectious Diseases: Antibacterials, Antifungals and Antivirals with Lipid-Associated Mechanisms of Action

Ostroumova,

Efimova

2023

Antibiotics

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One of the global challenges of the 21st century is the increase in mortality from infectious diseases against the backdrop of the spread of antibiotic-resistant pathogenic microorganisms. In this regard, it is worth targeting antibacterials towards the membranes of pathogens that are quite conservative and not amenable to elimination. This review is an attempt to critically analyze the possibilities of targeting antimicrobial agents towards enzymes involved in pathogen lipid biosynthesis or towards bacterial, fungal, and viral lipid membranes, to increase the permeability via pore formation and to modulate the membranes’ properties in a manner that makes them incompatible with the pathogen’s life cycle. This review discusses the advantages and disadvantages of each approach in the search for highly effective but nontoxic antimicrobial agents. Examples of compounds with a proven molecular mechanism of action are presented, and the types of the most promising pharmacophores for further research and the improvement of the characteristics of antibiotics are discussed. The strategies that pathogens use for survival in terms of modulating the lipid composition and physical properties of the membrane, achieving a balance between resistance to antibiotics and the ability to facilitate all necessary transport and signaling processes, are also considered.

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Near-Infrared Dyes: Towards Broad-Spectrum Antivirals

Cited by 2 publications

References 161 publications

Biological Action of Singlet Molecular Oxygen from the Standpoint of Cell Signaling, Injury and Death

Biological Action of Singlet Molecular Oxygen from the Standpoint of Cell Signaling, Injury and Death

Lipid-Centric Approaches in Combating Infectious Diseases: Antibacterials, Antifungals and Antivirals with Lipid-Associated Mechanisms of Action

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