Near infrared conjugated polymer nanoparticles (CPN™) for tracking cells using fluorescence and optoacoustic imaging

Muñiz-García, Ana; Pichardo, Alejandra Hernandez; Littlewood, James; Tasker, Suzannah; Sharkey, Jack; Wilm, Bettina; Peace, Hannah; O'Callaghan, Dermott; Green, Mark; Taylor, Arthur; Murray, Patricia

doi:10.1039/d3na00546a

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…The goal is to enhance the intraoperative visualization of anatomical structures, leading to safer and more efficient surgery. ICG fluorescence technology has received approval from the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for clinical use [ 7 ]. More recently, the utilization of ICG fluorescence technology has seen a remarkable surge.…”

Section: Introductionmentioning

confidence: 99%

Indocyanine green (ICG) fluorescence technology in pediatric robotic surgery

Esposito,

Masieri,

Cerulo

et al. 2024

J Robotic Surg

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This study aimed to report our experience in indocyanine green (ICG) fluorescence-guided surgery (FGS) in pediatric robotics. The data of 55 patients (35 boys and 20 girls), who underwent robotic surgery using ICG fluorescence in three institutions over the last 7 years, were retrospectively reviewed. The following robotic procedures were included: pyeloplasty (n = 21), complex Lich–Gregoir ureteral reimplantation (n = 8), varicocelectomy (n = 7), adnexal pathology resection (n = 8), partial nephrectomy (n = 4), nephrectomy (n = 4), renal cyst removal (n = 2), and excision of prostatic utricle (n = 1). The ICG was injected intravenously in all indications except for varicocele where intratesticular injection was done, and prostatic utricle or paraureteral diverticulum where trans-catheter injection was done. The ICG dosage was 0.2–0.3 mg/mL/kg. All the procedures were performed using da Vinci Xi platform. Firefly® allowed to switch form bright light to ICG-NIRF view and vice versa. All the procedures were accomplished in robotics without conversions to laparoscopy or open surgery. No episodes of allergy or anaphylaxis to ICG were recorded. An excellent ICG-NIRF view of target organs was obtained in all procedures. Based on our experience, we believe that application of ICG FGS in pediatric robotics enhances the identification of critical anatomical elements and pathological structures, thereby positively impacting both oncological and functional outcomes. This technique is safe, feasible, and versatile. We advocate the consideration of ICG as the standard of care in certain procedures such as partial nephrectomy, varicocele repair, tumor resection, and ovarian torsion. Nonetheless, further investigations are warranted to explore its potential broader applications in pediatric urology.

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Section: Introductionmentioning

confidence: 99%

Indocyanine green (ICG) fluorescence technology in pediatric robotic surgery

Esposito,

Masieri,

Cerulo

et al. 2024

J Robotic Surg

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Rational Design of NIR‐II Emitting Conjugated Polymer Derived Nanoparticles for Image‐Guided Cancer Interventions

Gill,

Srivastava,

Tropp

2024

Adv Healthcare Materials

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Due to the reduced absorption, light scattering, and tissue autofluorescence in the NIR‐II (1000–1700 nm) region, significant efforts are underway to explore diverse material platforms for in vivo fluorescence imaging, particularly for cancer diagnostics and image‐guided interventions. Of the reported imaging agents, nanoparticles derived from conjugated polymers (CPNs) offer unique advantages to alternative materials including biocompatibility, remarkable absorption cross‐sections, exceptional photostability, and tunable emission behavior independent of cell labeling functionalities. Herein we summarize the current state of NIR‐II emitting CPNs and highlight structure‐function‐property relationships that can be used to elevate the performance of next‐generation CPNs. Methods for particle processing and incorporating cancer targeting modalities are discussed, as well as detailed characterization methods to improve interlaboratory comparisons of novel materials. We then highlight contemporary methods to specifically apply CPNs for cancer diagnostics and therapies. This review not only summarizes the current state of the field, but offers future directions and provides clarity to the advantages of CPNs over other classes of imaging agents.This article is protected by copyright. All rights reserved

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Near infrared conjugated polymer nanoparticles (CPN™) for tracking cells using fluorescence and optoacoustic imaging

Abstract: Tracking the biodistribution of cell therapies is crucial for understanding their safety and efficacy. Optical imaging techniques are particularly useful for tracking cells due to their clinical translatability and potential...

Cited by 2 publications

References 33 publications

Indocyanine green (ICG) fluorescence technology in pediatric robotic surgery

Indocyanine green (ICG) fluorescence technology in pediatric robotic surgery

Rational Design of NIR‐II Emitting Conjugated Polymer Derived Nanoparticles for Image‐Guided Cancer Interventions

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