Near-infrared carbon dots-based fluorescence turn on aptasensor for determination of carcinoembryonic antigen in pleural effusion

Shao, Kang; Wang, Lanfang; Wen, Ying; Wang, Tao; Teng, Yuanjie; Shen, Zhenlu; Pan, Zaifa

doi:10.1016/j.aca.2019.03.056

Cited by 46 publications

(16 citation statements)

References 34 publications

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“…DNA transcribes RNA and RNA translates into proteins, thus some oligonucleotide or peptide molecules (aptamers) also bind well with DNA strand. The different interaction ability of DNA single strand and probe aptamer with carcinoembryonic antigen (CEA) was delicately exploited by Shao and coworkers for the efficient detection of CEA in pleural effusion . When the CDs-DNA biosensor was exposed to CEA, the fluorescence of CDs quenched by Au nanorods was restored (Figure C), and the recovery of fluorescence intensity is proportional to the concentration of CEA.…”

Section: Applications Of Cd-based Biosensorsmentioning

confidence: 99%

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Recent Developments of Carbon Dots in Biosensing: A Review

2020

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Early diagnosis of diseases is of great importance because it increases the chance of a cure and significantly reduces treatment costs. Thus, development of rapid, sensitive, and reliable biosensing techniques is essential for the benefits of human life and health. As such, various nanomaterials have been explored to improve performance of biosensors, among which, carbon dots (CDs) have received enormous attention due to their excellent performance. In this Review, the recent advancements of CDbased biosensors have been carefully summarized. First, biosensors are classified according to their sensing strategies, and the role of CDs in these sensors is elaborated in detail. Next, several typical CD-based biosensors (including CD-only, enzymatic, antigen− antibody, and nucleic acid biosensors) and their applications are fully discussed. Last, advantages, challenges, and perspectives on the future trends of CD-based biosensors are highlighted.

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Section: Applications Of Cd-based Biosensorsmentioning

confidence: 99%

Section: Applications Of Cd-based Biosensorsmentioning

confidence: 99%

Recent Developments of Carbon Dots in Biosensing: A Review

2020

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“…5 A) [ 100 ]. The fluorophore/quencher can also be replaced by other types of signal transduction, such as gold nanoparticles [ 101 ], carbon dots [ 102 ], quantum dots [ 103 ], or electrode surfaces [ 104 ]. Xiao et al designed a redox probe-labeled, signal-off electrochemical aptasensor for thrombin analysis.…”

Section: Aptamer-based Biosensormentioning

confidence: 99%

Aptamers used for biosensors and targeted therapy

Ning

2020

Biomedicine & Pharmacotherapy

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“…Their presence or quantitative changes may indicate the nature of the tumor, thereby contributing to tumor diagnosis, prognosis judgment, and treatment 8 , 9 . There were many reports about the detection of tumor markers, such as carcinoembryonic antigen (CEA) 10 , alpha fetoprotein (AFP) 11 , cancer antigen (CA) 125 12 and so on. Among many molecular markers, CEA is one of the tumor markers for many cancers, which can be used to indicate postoperative tumor recurrence 13 .…”

Section: Introductionmentioning

confidence: 99%

Gold nanorods-mediated efficient synergistic immunotherapy for detection and inhibition of postoperative tumor recurrence

Zhang

Wang

Tian

et al. 2021

Acta Pharmaceutica Sinica B

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Tumor recurrence after surgery is the main cause of treatment failure. However, the initial stage of recurrence is not easy to detect, and it is difficult to cure in the late stage. In order to improve the life quality of postoperative patients, an efficient synergistic immunotherapy was developed to achieve early diagnosis and treatment of post-surgical tumor recurrence, simultaneously. In this paper, two kinds of theranostic agents based on gold nanorods (AuNRs) platform were prepared. AuNRs and quantum dots (QDs) in one agent was used for the detection of carcinoembryonic antigen (CEA), using fluorescence resonance energy transfer (FRET) technology to indicate the occurrence of in situ recurrence, while AuNRs in the other agent was used for photothermal therapy (PTT), together with anti-PDL1 mediated immunotherapy to alleviate the process of tumor metastasis. A series of assays indicated that this synergistic immunotherapy could induce tumor cell death and the increased generation of CD3 + /CD4 + T-lymphocytes and CD3 + /CD8 + T-lymphocytes. Besides, more immune factors (IL-2, IL-6, and IFN- γ ) produced by synergistic immunotherapy were secreted than mono-immunotherapy. This cooperative immunotherapy strategy could be utilized for diagnosis and treatment of postoperative tumor recurrence at the same time, providing a new perspective for basic and clinical research.

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Near-infrared carbon dots-based fluorescence turn on aptasensor for determination of carcinoembryonic antigen in pleural effusion

Cited by 46 publications

References 34 publications

Recent Developments of Carbon Dots in Biosensing: A Review

Recent Developments of Carbon Dots in Biosensing: A Review

Aptamers used for biosensors and targeted therapy

Gold nanorods-mediated efficient synergistic immunotherapy for detection and inhibition of postoperative tumor recurrence

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