Near-Infrared AIE Dots with Chemiluminescence for Deep-Tissue Imaging

Abstract

A novel AIEgen named TBL was designed based on the classic CL emitter luminol. The NIR CL emission of TBL dots could penetrate through 3 cm-thick pork ham, which is much better than NIR fluorescence and blue CL emission. Moreover, the successful differentiation of tumor and normal tissue makes this system promising for CL-guided tumor diagnosis and surgery.

Synthesizing Ag+: MgS, Ag+: Nb2S5, Sm3+: Y2S3, Sm3+:Er2S3, and Sm3+:ZrS2 Compound Nanoparticles for Multicolor Fluorescence Imaging of Biotissues

“…It is worth mentioning that our samples present interesting NIR fluorescence ranging from 800 to 1100 nm, which is the so-called NIR-I region for deep tissue imaging. 51 However, we have to optimize the sample prepared in order to obtain a strong NIR fluorescence intensity for taking their unique advantage in achievable penetration depth. This can be done by adjusting the amount of Mg 2+ , Nb 5+ , Y 3+ , Er 3+ , and Zr 4+ ion treatment, which can change the amount of donors and acceptors and ultimately, the configuration of energy levels.…”

Aggregation-Induced Fluorogens in Bio-Detection, Tumor Imaging, and Therapy: A Review

“…49,23 Because of low photon scattering and phototoxicity, negligible autofluorescence, 22,23,50 deep tissue penetration, the NIR and two-photon capable AIEgens enlightens the biomedical application effectively. 47,48,50,51 The NIR capable AIE molecules are constructed by improving the D-A-D effect by installing substituents with strong electron donors and acceptors to elevate the HOMO level and lower the LUMO level. 43 Furthermore, the quantum efficiency of the molecules are boosted by careful design strategies.…”

“…For example, replacing the sulphur group in the BBTD acceptor unit with selenium shifts the emission maxima from 810 nm (9) to 897 nm (11). 51 On the other side, strengthening the electron-donor molecules (triphenylamine, thiophene, and alkoxy chains) lowers the bandgap to achieve NIR emission. 58 By introducing a high electron-donating moiety, e.g., N, N-diphenyl-4-(1,2,2-triphenylvinyl)aniline and AIE unit (TPE) with the central BBTD core, yields emission c. a.…”

Nanobiotechnology‐enabled energy utilization elevation for augmenting minimally‐invasive and noninvasive oncology thermal ablation

“…Comparing to PTTAs featuring narrow characteristic absorption, these black PTTAs with full spectrum absorption are much preferable. It can be attributed to the fact that they can absorb NIR light within NIR‐I and NIR‐II windows and convert them into heat, increasing the applicability since NIR light shares deep penetration and poor attenuation (Bordat et al, 2019; Cao et al, 2020; C. C. Liu, Wang, et al, 2020; Prodi et al, 2015; Smith et al, 2009). In practice, some narrow characteristic absorption peaks of some PTTAs are centered within NIR window, and these PTTAs are also favorable for PTA, for example, indocyanine green (ICG), gold nanostar or nanorod or nanocube, CuS, CuSe, Bi 2 S 3 , and so on (X. Cheng et al, 2017; Deng et al, 2019).…”