Near-infrared absorbing Ru(ii) complexes act as immunoprotective photodynamic therapy (PDT) agents against aggressive melanoma

Abstract

Mounting evidence over the past 20 years suggests that photodynamic therapy (PDT), an anticancer modality known mostly as a local treatment, has the capacity to invoke a systemic antitumor immune...

It Takes Three to Tango: The Length of the Oligothiophene Chain Determines the Nature of the Long‐Lived Excited State and the Resulting Photocytotoxicity of a Ruthenium(II) Photodrug

“…This trend is consistent with the trend for photocytotoxicity as reflected in the PI values that increase with n (see Figure 2d) [1] . This positive correlation between singlet oxygen quantum yields and photocytotoxicity suggests that singlet oxygen is involved in their mode of action [20–22] . Enhanced sensitivity toward oxygen is normally reflected as a drastic decrease in triplet excited state lifetime in the presence of oxygen [8] .…”

Modification of amyloid-beta peptide aggregation via photoactivation of strained Ru(ii) polypyridyl complexes

“…While visible light is incompatible with external activation of Ru1-3 due to limited tissue penetration, the recent development of near-infrared photoactivatable Ru complexes may provide an opportunity for this strategy in AD treatment moving forward. [95][96][97] Overall, our results show that the extended hydrophobic ligands present in Ru1 and Ru2 enhance the peptide interaction, especially at early time points, facilitating the formation of a covalent adduct between the Ru(II) complexes and Ab when samples are photoactivated.…”

An ultra-stable bio-inspired bacteriochlorin analogue for hypoxia-tolerant photodynamic therapy

“…The short wavelength light absorbed by PSs cannot reach the deep tissue due to absorption of the skin and subcutaneous adipose tissue, resulting in lower photoconversion, serious tissue damage and the limited clinical application of PDT in deep tumors 3 . To address this issue, some strategies such as two-photon excitation (TPE) technique 4,5 and upconversion nanoparticles (UCNPs) 6,7 had been introduced for the therapy of deep tumors, but the complex equipment and the low conversion efficiency will bring about new problems for the clinic application 8,9 . Thus, PSs with strong NIR (700-1000 nm) absorption, which display deeper tissue penetration and minimized photodamage, have attracted intense research efforts for eradicating tumor in deep site [10][11][12] .…”