Near infra-red light responsive carbon nanotubes@mesoporous silica for photothermia and drug delivery to cancer cells

Li, Bei; Harlepp, Sébastien; Gensbittel, Valentin; Wells, Connor J. R.; Bringel, O.; Goetz, Jacky G.; Bégin‐Colin, Sylvie; Tasso, Mariana; Bégin, Dominique; Mertz, Damien

doi:10.1016/j.mtchem.2020.100308

Cited by 28 publications

(22 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The inorganic materials with photothermal effects include carbon nanotubes [ 49 , 50 , 51 ], reduced graphene oxide (rGO) [ 52 , 53 ], gold nanoparticles [ 54 , 55 , 56 ], BP [ 57 , 58 ], AuPds [ 31 ], silver [ 59 ], TiO 2 [ 60 ], and platinum nanoparticles [ 61 ]. However, the aggregation of nanoparticles in organisms limits their applications.…”

Section: Composition Of Hydrogels With Photothermal Effectsmentioning

confidence: 99%

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

Zhang

Tan

et al. 2021

Polymers

View full text Add to dashboard Cite

Photothermal treatment (PTT) is a promising strategy to deal with multidrug-resistant bacteria infection and promote tissue regeneration. Previous studies demonstrated that hyperthermia can effectively inhibit the growth of bacteria, whereas mild heat can promote cell proliferation, further accelerating wound healing and bone regeneration. Especially, hydrogels with photothermal properties could achieve remotely controlled drug release. In this review, we introduce a photothermal agent hybrid in hydrogels for a photothermal effect. We also summarize the potential mechanisms of photothermal hydrogels regarding antibacterial action, angiogenesis, and osteogenesis. Furthermore, recent developments in photothermal hydrogels in wound healing and bone regeneration applications are introduced. Finally, future application of photothermal hydrogels is discussed. Hydrogels with photothermal effects provide a new direction for wound healing and bone regeneration, and this review will give a reference for the tissue engineering.

show abstract

Section: Composition Of Hydrogels With Photothermal Effectsmentioning

confidence: 99%

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

Zhang

Tan

et al. 2021

Polymers

View full text Add to dashboard Cite

show abstract

“…Aside from controlled drug delivery systems which require injection to the tumor area, implant-based controlled drug delivery systems, have the advantage of providing a controlled but also localized delivery of the drug and can minimize systemic toxicity. Electrospun PLGA scaffolds, 3D printed PLGA, carbon nanotubes, and mesoporous silica nanoparticles have been used to encapsulate therapeutic agents to be used in implantable controlled drug delivery systems [ 29 , 37 , 38 ]. Of such methods, the distinguishing property of the electropsun scaffolds, is their ability to be tuned and provide various release kinetics of the drug, depending on the selection of the polymer used to fabricate the scaffold [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Novel Honokiol-eluting PLGA-based scaffold effectively restricts the growth of renal cancer cells

et al. 2020

View full text Add to dashboard Cite

Renal Cell Carcinoma (RCC) often becomes resistant to targeted therapies, and in addition, dose-dependent toxicities limit the effectiveness of therapeutic agents. Therefore, identifying novel drug delivery approaches to achieve optimal dosing of therapeutic agents can be beneficial in managing toxicities and to attain optimal therapeutic effects. Previously, we have demonstrated that Honokiol, a natural compound with potent anti-tumorigenic and anti-inflammatory effects, can induce cancer cell apoptosis and inhibit the growth of renal tumors in vivo. In cancer treatment, implant-based drug delivery systems can be used for gradual and sustained delivery of therapeutic agents like Honokiol to minimize systemic toxicity. Electrospun polymeric fibrous scaffolds are ideal candidates to be used as drug implants due to their favorable morphological properties such as high surface to volume ratio, flexibility and ease of fabrication. In this study, we fabricated Honokiol-loaded Poly(lactide-co-glycolide) (PLGA) electrospun scaffolds; and evaluated their structural characterization and biological activity. Proton nuclear magnetic resonance data proved the existence of Honokiol in the drug loaded polymeric scaffolds. The release kinetics showed that only 24% of the loaded Honokiol were released in 24hr, suggesting that sustained delivery of Honokiol is feasible. We calculated the cumulative concentration of the Honokiol released from the scaffold in 24hr; and the extent of renal cancer cell apoptosis induced with the released Honokiol is similar to an equivalent concentration of direct application of Honokiol. Also, Honokiol-loaded scaffolds placed directly in renal cell culture inhibited renal cancer cell proliferation and migration. Together, we demonstrate that Honokiol delivered through electrospun PLGA-based scaffolds is effective in inhibiting the growth of renal cancer cells; and our data necessitates further in vivo studies to explore the potential of sustained release of therapeutic agents-loaded electrospun scaffolds in the treatment of RCC and other cancer types.

show abstract

“…For instance, Matrigel ® provided a scaffold for CNTs conjugated to mesoporous silica for the pulsatile drug delivery of an anticancer agent [ 146 ]. In particular, doxorubicin was released through a photo-thermal effect that was triggered by near-infrared light irradiation of the responsive CNTs [ 154 ]. Whey proteins were recently reported to facilitate CNT dispersion within their hydrogels, with CNTs leading to shortening of the protein fibrils that may have useful implications in the development of innovative therapies for amyloidoses [ 173 ].…”

Section: Recent Advancements On Hydrogels With Carbon Nanomaterials For Medicinementioning

confidence: 99%

Smart Hydrogels Meet Carbon Nanomaterials for New Frontiers in Medicine

2021

View full text Add to dashboard Cite

Carbon nanomaterials include diverse structures and morphologies, such as fullerenes, nano-onions, nanodots, nanodiamonds, nanohorns, nanotubes, and graphene-based materials. They have attracted great interest in medicine for their high innovative potential, owing to their unique electronic and mechanical properties. In this review, we describe the most recent advancements in their inclusion in hydrogels to yield smart systems that can respond to a variety of stimuli. In particular, we focus on graphene and carbon nanotubes, for applications that span from sensing and wearable electronics to drug delivery and tissue engineering.

show abstract

Near infra-red light responsive carbon nanotubes@mesoporous silica for photothermia and drug delivery to cancer cells

Cited by 28 publications

References 65 publications

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

Novel Honokiol-eluting PLGA-based scaffold effectively restricts the growth of renal cancer cells

Smart Hydrogels Meet Carbon Nanomaterials for New Frontiers in Medicine

Contact Info

Product

Resources

About