Near Full-Length Genome Sequence of a Novel HIV-1 Recombinant Form (CRF01_AE/B) Detected Among Men Who Have Sex with Men in Jilin Province, China

Abstract

We report here a novel HIV-1 recombinant form (CRF01_AE/B) detected from a comprehensive HIV-1 molecular epidemiologic study among men who have sex with men (MSM) in Jilin province of northeastern China. The near full-length genome (NFLG) analyses showed that the novel HIV-1 recombinant isolate ( JL.RF07) was composed of CRF01_AE cluster 5 (northeastern China origin) and subtype B (U.S. and European origin), with six recombinant breakpoints observed in the pol, vif, tat, rev, and env gene regions. To the best of our knowledge, this is the first detection of a novel HIV-1 recombinant form (CRF01_AE/B) in Jilin, which may indicate an active transmission network of HIV-1 infection among MSM in the region. Further studies of the molecular epidemiology of the HIV-1 epidemic among MSM in northeastern China are necessary to gain a fuller understanding of the transmission network and potential public health impact of HIV-1 among MSM in this region.

Determinants and Status of HIV Disclosure among Reproductive Age Women on Antiretroviral Therapy at Three Health Facilities in Jimma Town, Ethiopia, 2017

“…In this study, the main reasons of respondents for not disclosing HIV status were fear of stigma and discrimination, and lack of trust on people. This finding is also supported by other studies [15,16].…”

“…This result is consistent with the findings from Ethiopia (Southern region) [11]. However, the current finding was lower when compared to studies conducted in different part of Ethiopia [12][13][14], Tanzania [15] and Zimbabwe [16]. The possible explanation for this difference might be due to the socio-demographic difference; plus this study includes all health facilities of ART clinics and uses only reproductive age women as study population.…”

Molecular epidemiology is becoming complex under the dynamic HIV prevalence: The perspective from Harbin, China

“…Co‐circulation of the diverse HIV‐1 subtype prevalence greatly increases the probability of HIV‐1 recombination. Based on the CRF01_AE continuous pandemic nationwide, more and more URFs were identified with CRF01_AE as the main component to appear, such as the CRF07_ BC/01_AE and CRF01_AE/B recombination, in the MSM population from Sichuan and Jilin [Li et al, , ; Wei et al, ], as well as the population of intravenous drug users in Jiangsu [Guo et al, ]. In addition, the novel HIV‐1 circulating recombinant form (CRF65_cpx), which is comprised of CRF01_AE and subtypes B and C, was also identified in western Yunnan [Feng et al, ].…”

Identification of a Novel HIV-1 Second-Generation Recombinant Form (CRF01_AE/CRF07_BC) in Jilin, China

“…All of the recombinants are identified among heterosexuals or MSM. 12,[18][19][20] The emergence of multiple second-generation recombinants suggests the presence of complex transmission networks of different HIV subtype/CRF infections among sexual transmissions in this region. Therefore, a continuing HIV-1 molecular epidemiologic investigation is necessary to characterize the transmission networks within subtypes and CRFs, which is of great importance in understanding the dynamics of the HIV-1 epidemic in this region.…”