Near Full-Length Genome Identification of a Novel HIV-1 Recombinant Form (CRF01_AE/B′/C) Among Heterosexuals in Jilin, China

Li, Xingguang; Ning, Chuanyi; Chen, Yanli; Feng, Yi; Wei, Min; Xing, Hui; Shao, Yiming

doi:10.1089/aid.2013.0278

Cited by 12 publications

(5 citation statements)

References 9 publications

(9 reference statements)

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“…In this study, the main reasons of respondents for not disclosing HIV status were fear of stigma and discrimination, and lack of trust on people. This finding is also supported by other studies [15,16].…”

Section: Discussionsupporting

confidence: 91%

“…This result is consistent with the findings from Ethiopia (Southern region) [11]. However, the current finding was lower when compared to studies conducted in different part of Ethiopia [12][13][14], Tanzania [15] and Zimbabwe [16]. The possible explanation for this difference might be due to the socio-demographic difference; plus this study includes all health facilities of ART clinics and uses only reproductive age women as study population.…”

Section: Discussionsupporting

confidence: 89%

See 1 more Smart Citation

Determinants and Status of HIV Disclosure among Reproductive Age Women on Antiretroviral Therapy at Three Health Facilities in Jimma Town, Ethiopia, 2017

Kassahun¹,

Tenaw²,

Belachew³

et al. 2018

Health Sci J

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 89%

Determinants and Status of HIV Disclosure among Reproductive Age Women on Antiretroviral Therapy at Three Health Facilities in Jimma Town, Ethiopia, 2017

Kassahun¹,

Tenaw²,

Belachew³

et al. 2018

Health Sci J

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“…In recent years, many novel HIV-1 recombinant strains in heterosexuals have since been confirmed by using molecular subtyping in China [32–34], suggesting that heterosexual transmission is intermixed with all other high-risk populations and contribute to the complexity of the HIV-1 epidemic. In this study, several potential HIV-1 recombinant strains may be present in some subjects.…”

Section: Discussionmentioning

confidence: 99%

HIV-1 genotype diversity and distribution characteristics among heterosexually transmitted population in Jiangsu province, China

Xiao

Zhou

et al. 2019

Virol J

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Background Heterosexual transmission has contributed greatly to the current HIV-1 epidemic in China. However, the HIV-1 genetic characteristics in the heterosexually transmitted population in Jiangsu province remained unclear. Methods A molecular epidemiological investigation on heterosexual transmission of HIV-1 was conducted across Jiangsu province. 301 HIV-1 patients infected through heterosexual transmission were involved in this study. The epidemiological information was investigated by trained staff via face-to-face interviews. Blood samples were taken from each patient, HIV-1 RNA was extracted from the plasma, and used for amplifying the gag and env genes followed by further products sequencing. The genotypes of HIV-1 were determined using phylogenetic tree analyses in the neighbor-joining method. Results A total of 262 samples were successfully taken for genotyping. The main subtypes which accounted for 90.5% of all HIV-1 strains are CRF01_AE (45.4%), CRF07_BC (21.4%), subtype B (12.6%), CRF08_BC (11.1%). Minor subtypes were also detected, such as CRF68_01B, subtype C, CRF55_01B, CRF02_AG and subtype A. Time trend analysis suggested the prevalence of subtype B and CRF08_BC decreased gradually, but the prevalence of CRF01_AE increased over time. A relatively higher prevalence of CRF07_BC in Central Jiangsu and subtype B were detected in South Jiangsu, while a relatively lower prevalence of subtype B and CRF08_BC were detected in Central Jiangsu. Conclusion Complex and unbalanced HIV distribution characteristics suggest that heterosexual transmission of HIV needs to be taken seriously. It is necessary to implement more effective and comprehensive intervention strategies for further control of HIV-1 dissemination.

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“…All of the recombinants are identified among heterosexuals or MSM. 12,[18][19][20] The emergence of multiple second-generation recombinants suggests the presence of complex transmission networks of different HIV subtype/CRF infections among sexual transmissions in this region. Therefore, a continuing HIV-1 molecular epidemiologic investigation is necessary to characterize the transmission networks within subtypes and CRFs, which is of great importance in understanding the dynamics of the HIV-1 epidemic in this region.…”

mentioning

confidence: 99%

Identification of a Novel HIV-1 Second-Generation Recombinant Form (CRF01_AE/CRF07_BC) in Jilin, China

Feng

Li²,

Zang³

et al. 2014

AIDS Research and Human Retroviruses

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We report here a novel HIV-1 second-generation recombinant form (CRF01_AE/CRF07_BC) isolated from an HIV-positive male subject infected through heterosexual contact in Jilin province in northeastern China. Phylogenic analysis shows that this novel second-generation recombinant ( JL.RF09) was composed of two well-established circulating recombinant forms (CRF01_AE and CRF07_BC), with two recombinant breakpoints observed in the vpu/env and env gene regions, respectively. The CRF01_AE region of the recombinant was clustered together with a previously described subcluster 4a lineage of CRF01_AE, which is exclusively circulating among men who have sex with men (MSM) in northern China, indicating that the parental origin of the CRF01_AE region in JL.RF09 was from MSM in north China. The CRF07_BC regions of the recombinant are clustered within the CRF07_BC cluster but are distinct from other CRF07_BC references. The detailed origin of CRF07_BC in this recombinant is still not clear. The emergence of the novel HIV-1 recombinant indicates the ongoing generation of recombinants involving CRF01_AE and CRF07_BC, and may provide vital insights into our understanding of the dynamics and complexity of the HIV-1 epidemic in China.

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Near Full-Length Genome Identification of a Novel HIV-1 Recombinant Form (CRF01_AE/B′/C) Among Heterosexuals in Jilin, China

Cited by 12 publications

References 9 publications

Determinants and Status of HIV Disclosure among Reproductive Age Women on Antiretroviral Therapy at Three Health Facilities in Jimma Town, Ethiopia, 2017

Determinants and Status of HIV Disclosure among Reproductive Age Women on Antiretroviral Therapy at Three Health Facilities in Jimma Town, Ethiopia, 2017

HIV-1 genotype diversity and distribution characteristics among heterosexually transmitted population in Jiangsu province, China

Identification of a Novel HIV-1 Second-Generation Recombinant Form (CRF01_AE/CRF07_BC) in Jilin, China

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