Near-field acoustic densimeter and viscosimeter

Patois, R.; Vairac, Pascal; Cretin, B.

doi:10.1063/1.1286308

Cited by 21 publications

(19 citation statements)

References 11 publications

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“…Frequency shifts are clearly observed among all liquid combinations. The bandwidth Df increases as the quality factor decreases, a fact that has been observed by other investigators (Patois et al, 2000). As derived in the Appendix, the Q-factor variation for two liquids follows ½s 2 À s 1 1=2 Â ðm 2 þ m 1 Þ À1 versus single liquid's m À1 , Fig.…”

Section: Solution and Numerical Resultssupporting

confidence: 78%

“…The invention of the atomic force microscope (AFM) (Binnig et al, 1986) encouraged numerous investigations in areas such as dynamic properties of microbeams for sampling surfaces in gases and liquids (Butt et al, 1993;Chen et al, 1994;Walters et al, 1996), measurements of density and viscosity in liquids (Inaba et al, 1993;Oden et al, 1996;Patois et al, 2000), monitoring chemical reactions (Ahmed et al, 2001), cell detection (Yi et al, 2003), and dynamic effects near confining walls (Naik et al, 2003). Among microsensor designs based on microplate dynamics we find concepts based on surface shear oscillations for measuring liquid density and viscosity (Martin et al, 1994;Jakoby et al, 2003), on micromachined diaphragms with piezoelectric thin films (Zhang and Kim, 2003) and on electrothermally excited disk shape structures for chemical and biological applications (Seo and Brand, 2005), to name only a handful of contributions.…”

Section: Introductionmentioning

confidence: 99%

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Microfluidic device concept based on microoscillator dynamics at a liquid–liquid interface

Allievi

2008

Journal of Fluids and Structures

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Section: Solution and Numerical Resultssupporting

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Microfluidic device concept based on microoscillator dynamics at a liquid–liquid interface

Allievi

2008

Journal of Fluids and Structures

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“…Caspase 7 was also analyzed further because of its ability to induce apoptosis ADAM-10 hydrolysis of Substance P Neprilysin is thought to be the main endopetidase which cleaves Substance P [82]. However, another neprilysin substrate, b-amyloid peptide [36], is also known to be hydrolyzed by ADAM-10 [65], raising the possibility that SP is also an ADAM-10 substrate. Purified SP was incubated in vitro with purified ADAM-10, and hydrolysis products were separated by HPLC and examined by MALDI-TOF mass spectrometry.…”

Section: Capsaicin Treatment Alters Gaea Profiles In Primary Tumorsmentioning

confidence: 99%

Capsaicin-induced inactivation of sensory neurons promotes a more aggressive gene expression phenotype in breast cancer cells

Erin

Zhao

Bylander

et al. 2006

Breast Cancer Res Treat

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Capsaicin-induced inactivation of sensory neurons has been reported to enhance metastasis of a murine breast cancer cell line, specifically enhancing myocardial metastases. Here we characterized changes in gene expression patterns in primary tumors which developed in capsaicin-treated vs. control mice. We identified a small cohort of genes (17) which all showed significant decreases in expression levels. All of the identified genes have been linked to cell growth, differentiation, and/or cancer progression. Three representative genes, Caspase-7 (an executor of apoptosis), ADAM-10 (A Disintegrin and Metalloprotease), and Elk-3 (a transcriptional repressor of the ternary factor subfamily of the Ets factors) were further investigated. All three showed dramatic downregulation at the protein level in primary tumors from capsaicin-treated animals compared with control (vehicle-treated) animals, and their expression was also lost in cell culture. Elk-3 and Caspase-7 were not expressed in vitro in cultured cell lines, suggesting that their expression was induced by the tumor microenvironment. Loss of Caspase-7 expression can be expected to result in loss of function of apoptotic pathways. At first glance, loss of ADAM-10 expression would be expected to result in decreased invasive capability, due to loss of matrix metalloprotease activity. However, just the opposite appears to be true. We found that ADAM-10 actually hydrolyzes Substance P. Specifically ADAM-10 produces the same growth-inhibitory products from Substance P (i.e., SP (1-7)) that Neprilysin does, so that loss of ADAM-10 expression actually results in loss of production of growth inhibitory peptides from Substance P. Similarly, ADAM-10 also efficiently hydrolyzes Calcitonin Gene-Related Peptide, which may act in concert with Substance P. Finally, overactivity of Ets transcriptional suppressor functions has been linked to inhibition of tumorigenesis (e.g., Erf and Mef), and in addition loss of Elk-3 expression might also be be linked to tumorigenesis via loss of its putative anti-inflammatory activities. There is anecdotal evidence in the literature to indicate that the rest of the down-regulated genes may also contribute to development of a more aggressive phenotype in this breast cancer model.

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“…There are also fluid-filled vibrating U-tube densimeters fabricated with MEMS albeit with a square rather than the traditional circular cross section [15][16][17]. In addition to these devices, there are numerous applications of cantilever beams (developed from the devices used in atomic force microscopy [18]) to the measurement of density and viscosity [19][20][21][22][23][24][25][26][27][28]. The width and length of cantilevers vary from about 2 to 200 µm with a thickness of the order of 1 µm [29].…”

Section: Introductionmentioning

confidence: 99%

A Vibrating Plate Fabricated by the Methods of Microelectromechanical Systems (MEMS) for the Simultaneous Measurement of Density and Viscosity: Results for Argon at Temperatures Between 323 and 423K at Pressures up to 68 MPa

et al. 2006

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In the petroleum industry, measurements of the density and viscosity of petroleum reservoir fluids are required to determine the value of the produced fluid and the production strategy. Measurements of the density and viscosity of petroleum fluids require a transducer that can operate at reservoir conditions, and results with an uncertainty of about ±1% in density and ±10% in viscosity are needed to guide value and exploitation calculations with sufficient rigor. Necessarily, these specifications place robustness as a superior priority to accuracy for the design. A vibrating plate, with dimensions of the order of 1 mm and a mass of about 0.12 mg, clamped along one edge, has been fabricated, with the methods of Microelectromechanical (MEMS) technology, to provide measurements of both density and viscosity of fluids in which it is immersed. The resonance frequency (at pressure p = 0 is about 12 kHz) and quality factor (at p = 0 is about 2 800) of the first order bending (flexural) mode of the plate are combined with semi-empirical working equations, coefficients obtained by calibration, and the mechanical properties of the plate to provide the density and viscosity of the fluid into which it is immersed. When the device was surrounded by argon at temperatures between 348 and 423 K and at pressures between 20 and 68 MPa, the density and viscosity were determined with an expanded (k = 2) uncertainty, including the calibration, of about ±0.35% and ±3%, respectively. These results, when compared with accepted correlations for argon reported in the literature, were found to lie within ±0.8% for density and less than ±5% for viscosity of literature values, which are within a reasonable multiple of the relative combined expanded (k = 2) uncertainty.

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Near-field acoustic densimeter and viscosimeter

Cited by 21 publications

References 11 publications

Microfluidic device concept based on microoscillator dynamics at a liquid–liquid interface

Microfluidic device concept based on microoscillator dynamics at a liquid–liquid interface

Capsaicin-induced inactivation of sensory neurons promotes a more aggressive gene expression phenotype in breast cancer cells

A Vibrating Plate Fabricated by the Methods of Microelectromechanical Systems (MEMS) for the Simultaneous Measurement of Density and Viscosity: Results for Argon at Temperatures Between 323 and 423K at Pressures up to 68 MPa

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