Near fatal acute colchicine intoxication in a child. A case report

Abstract

To the best of our knowledge, this is the first time colchicine intoxication in this age group has been described in the English literature.

Grapefruit Juice and its Constituents Augment Colchicine Intestinal Absorption: Potential Hazardous Interaction and the Role of P-Glycoprotein

“…Hence, a mechanistic interaction with GFJ, a P-gp and CYP3A4 inhibitor, is suggested. Moreover, a near fatal acute colchicine intoxication in a child after drinking high amounts of natural GFJ was recently described (25). Hence, in this study we directly investigated the possible effects of GFJ on colchicine intestinal permeability.…”

“…Hence, a potential mechanistic-based pharmacokinetic interaction with GFJ is suggested. Moreover, a case report describing a near fatal acute colchicine intoxication in a child after drinking high amounts of natural GFJ was recently published (25).…”

Enzyme‐ and transporter‐mediated beverage–drug interactions: An update on fruit juices and green tea

“…For example, Peynaud et al reported nephrotoxicity of tacrolimus after consumption of a large amount of marmalade that contained grapefruit (1.5 kg eaten during the preceding 1 week) . Goldbart et al reported myelotoxicity of colchicine after consumption of juice 1 L/day for the preceding 2 months . The limitation of the case reports is that the patients took multiple drugs together, and there is no information available regarding the concentration of the drug with toxicity.…”

Colchicine‐Containing Plants

“…22 In a study of volunteers administered 0.5 -1.5 g colchicine orally, the volume of distribution (V d ) ranged from about 11 -15 L/kg. 22 In a study of volunteers administered 0.5 -1.5 g colchicine orally, the volume of distribution (V d ) ranged from about 11 -15 L/kg.…”