Near Drowning in Humans

Hasan, Saad; Avery, Wilbur G.; Fabian, Carl E.; Sackner, Marvin A.

doi:10.1378/chest.59.2.191

Cited by 29 publications

(1 citation statement)

References 8 publications

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“…For further comparison, we reviewed reports of near-drowning as examples of severe, generalized hypoxia. The studies included 329 patients; in only three patients were elevations of transaminase levels noted (24)(25)(26)(27). None of the studies mentioned severe liver injury as a complication of near-drowning.…”

Section: Discussionmentioning

confidence: 99%

Acute Liver Injury after Protracted Seizures in Children

Ussery,

Henar,

Black

et al. 1989

J. pediatr. gastroenterol. nutr.

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Three children were observed to have extensive liver injury following protracted seizures. Two recovered with supportive care and one died from central nervous system complications. When first measured, the levels of aminotransferases were minimally elevated, but they increased to 250 to 8,000 times normal within 12 to 24 h after the seizure episode. They fell to near normal over the next 8 to 11 days in the survivors, and to one sixth of the peak level by 4 days in the patient who died. A percutaneous liver biopsy from one child demonstrated centrolobular necrosis consistent with severe ischemic injury. Common causes for liver dysfunction, including viral hepatitis, drug hepatitis, and Reye syndrome, were excluded on clinical, serologic, and histologic grounds. We reason that hepatic injury resulted from ischemia. We speculate that prior treatment with anticonvulsants, which are capable of inducing mixed‐function oxidases in the liver, aggravated the ischemia‐reperfusion injury by increasing the production of reactive oxygen intermediates and reducing cytoprotective mechanisms. Prevention of such injury should be directed toward control of seizures and early respiratory support when seizures occur, not restructuring medication regimens.

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Section: Discussionmentioning

confidence: 99%