NDRG2 is expressed on enteric glia and altered in conditions of inflammation and oxygen glucose deprivation/reoxygenation

Zhang, Yuxin; Gao, Hui; Li, Na; Chang, Haiqing; Cheng, Bo; Li, Yansong; Miao, Jiwen; Li, Shuang; Wang, Qiang

doi:10.1007/s10735-020-09927-z

Cited by 5 publications

(2 citation statements)

References 49 publications

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“…Its cytoplasmic localization allows visualization in cell bodies and processes. Its involvement in pathogenesis development was reported in experimental autoimmune encephalomyelitis mice and ischemia models; however, it may act through a different signaling pathway causing opposite effects [ 168 , 169 , 170 ].…”

Section: Astroglia Activationmentioning

confidence: 99%

Beyond the GFAP-Astrocyte Protein Markers in the Brain

et al. 2021

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The idea of central nervous system as one-man band favoring neurons is long gone. Now we all are aware that neurons and neuroglia are team players and constant communication between those various cell types is essential to maintain functional efficiency and a quick response to danger. Here, we summarize and discuss known and new markers of astroglial multiple functions, their natural heterogeneity, cellular interactions, aging and disease-induced dysfunctions. This review is focused on newly reported facts regarding astrocytes, which are beyond the old stereotypes. We present an up-to-date list of marker proteins used to identify a broad spectrum of astroglial phenotypes related to the various physiological and pathological nervous system conditions. The aim of this review is to help choose markers that are well-tailored for specific needs of further experimental studies, precisely recognizing differential glial phenotypes, or for diagnostic purposes. We hope it will help to categorize the functional and structural diversity of the astroglial population and ease a clear readout of future experimental results.

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Section: Astroglia Activationmentioning

confidence: 99%

Beyond the GFAP-Astrocyte Protein Markers in the Brain

et al. 2021

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“…NDRG2 depletion led to destruction of adhesive junctive structures, reduced epithelial barrier function and increased intestinal epithelial permeability. However, NDRG2 has also been found to be upregulated after proinflammatory cytokine intervention in intestinal glia exposed to hypoxia-glucose deprivation/reoxygenation [ 29 ]. In our study, upregulating NDRG2 levels in IL-1β-challenged ATDC5 cells improved cell viability while inhibited cell apoptosis and inflammatory responses.…”

Section: Discussionmentioning

confidence: 99%