2011
DOI: 10.1093/jac/dkr135
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NDM-2 carbapenemase in Acinetobacter baumannii from Egypt

Abstract: This work further underlines the spread of NDM carbapenemases in A. baumannii, and the spread of the corresponding gene in the Middle East. It also describes the first variant of NDM-1.

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Cited by 192 publications
(159 citation statements)
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“…These isolates were resistant to high levels of all b-lactams, including carbapenems. Additionally, the first known variant of the bla NDM-1 gene, namely bla NDM-2 , encoding NDM-2, was identified in an A. baumannii isolate from Egypt (30) and was associated with ISAba125, which provided promoter sequences involved in bla NDM-2 expression. Overall, MBLs confer high levels of carbapenem resistance in A. baumannii, and also confer resistance to other b-lactams with the exception of aztreonam.…”
Section: Acquired Carbapenem-hydrolyzing B-lactamasesmentioning
confidence: 99%
“…These isolates were resistant to high levels of all b-lactams, including carbapenems. Additionally, the first known variant of the bla NDM-1 gene, namely bla NDM-2 , encoding NDM-2, was identified in an A. baumannii isolate from Egypt (30) and was associated with ISAba125, which provided promoter sequences involved in bla NDM-2 expression. Overall, MBLs confer high levels of carbapenem resistance in A. baumannii, and also confer resistance to other b-lactams with the exception of aztreonam.…”
Section: Acquired Carbapenem-hydrolyzing B-lactamasesmentioning
confidence: 99%
“…7,16 These MBLs are IMP-like, VIM-like, Seoul imipenemase (SIM-1), Sao Paulo (SPM-1), German imipenemase (GIM-1), New Delhi (NDM-1) and NDM-2. 7,[17][18][19][20] MBL enzymes require the presence of metal ions to be active. 16 Broadly, MBLs can be divided into those that are mobile and those that are normally carried by the bacterium on its chromosome.…”
mentioning
confidence: 99%
“…Switzerland and the Balkan region confirmed the presence of NDM-1-positive bacteria in May and June 2011, respectively [19,20]. The first variant of NDM-1 (designated as NDM-2) was reported in June 2011 [21]. It harbored a C to G substitution at position 82, resulting in an amino acid substitution of proline to alanine at position 28 [21].…”
Section: A Concise Update On Global Epidemiology (2009-2012)mentioning
confidence: 84%
“…The first variant of NDM-1 (designated as NDM-2) was reported in June 2011 [21]. It harbored a C to G substitution at position 82, resulting in an amino acid substitution of proline to alanine at position 28 [21]. Several variants of NDM-1 have been reported, NDM-6 (GenBank: JN967644.1) being the latest addition to the list.…”
Section: A Concise Update On Global Epidemiology (2009-2012)mentioning
confidence: 99%