NDM-2 carbapenemase in Acinetobacter baumannii from Egypt

Kaase, Martin; Nordmann, Patrice; Wichelhaus, Thomas A.; Gatermann, Sören; Bonnin, Rémy A.; Poirel, Laurent

doi:10.1093/jac/dkr135

Cited by 193 publications

(159 citation statements)

References 9 publications

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“…These isolates were resistant to high levels of all b-lactams, including carbapenems. Additionally, the first known variant of the bla NDM-1 gene, namely bla NDM-2 , encoding NDM-2, was identified in an A. baumannii isolate from Egypt (30) and was associated with ISAba125, which provided promoter sequences involved in bla NDM-2 expression. Overall, MBLs confer high levels of carbapenem resistance in A. baumannii, and also confer resistance to other b-lactams with the exception of aztreonam.…”

Section: Acquired Carbapenem-hydrolyzing B-lactamasesmentioning

confidence: 99%

Genetic basis of antibiotic resistance in pathogenic Acinetobacter species

2011

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SummaryAntibiotic resistance in Acinetobacter spp., particularly Acinetobacter baumannii, is increasing rapidly. A. baumannii possesses two intrinsic b-lactamase genes, in addition to weak permeability and efflux systems, that together confer a natural reduced susceptibility to antibiotics. In addition, numerous acquired mechanisms of resistance have been identified in A. baumannii. The very high genetic plasticity of A. baumannii allows an accumulation of resistance determinants that give rise to multidrug resistance at an alarming rate. The role of novel genetic elements, such as resistance islands, in concentrating antibiotic resistance genes in A. baumannii requires detailed investigation in the near future.

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Section: Acquired Carbapenem-hydrolyzing B-lactamasesmentioning

confidence: 99%

Genetic basis of antibiotic resistance in pathogenic Acinetobacter species

2011

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“…7,16 These MBLs are IMP-like, VIM-like, Seoul imipenemase (SIM-1), Sao Paulo (SPM-1), German imipenemase (GIM-1), New Delhi (NDM-1) and NDM-2. 7,[17][18][19][20] MBL enzymes require the presence of metal ions to be active. 16 Broadly, MBLs can be divided into those that are mobile and those that are normally carried by the bacterium on its chromosome.…”

mentioning

confidence: 99%

Prevalence of carbapenem resistance genes inAcinetobacter baumanniiisolated from clinical specimens obtained from an academic hospital in South Africa

Kock

Bellomo

Storm

et al. 2013

Southern African Journal of Epidemiology and Infection

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Original Research: Prevalence of carbapenem resistance genes in Acinetobacter baumannii isolated from clinical specimens Acinetobacter baumannii is an important cause of hospital-acquired infections. The occurrence of carbapenem resistance that is caused by the carbapenem-hydrolysing class D β-lactamases and the metallo-β-lactamases (MBLs) limits the range of therapeutic alternatives in treating A. baumannii infections. In this study, two multiplex polymerase chain reactions were performed to screen for both carbapenem-hydrolysing class D β-lactamases and MBL genes in 97 clinical isolates of A. baumannii. Oxacillinase (OXA)-51 had a prevalence of 83% (81/97), and OXA-23 had a prevalence of 59% (57/97). One isolate was positive for an MBL [Verona integron-encoded metallo β-lactamases (VIM)]. Therefore, continuous surveillance and monitoring of A. baumannii is crucial because of the high prevalence of antibiotic resistance genes.Peer reviewed.

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“…Switzerland and the Balkan region confirmed the presence of NDM-1-positive bacteria in May and June 2011, respectively [19,20]. The first variant of NDM-1 (designated as NDM-2) was reported in June 2011 [21]. It harbored a C to G substitution at position 82, resulting in an amino acid substitution of proline to alanine at position 28 [21].…”

Section: A Concise Update On Global Epidemiology (2009-2012)mentioning

confidence: 84%

“…The first variant of NDM-1 (designated as NDM-2) was reported in June 2011 [21]. It harbored a C to G substitution at position 82, resulting in an amino acid substitution of proline to alanine at position 28 [21]. Several variants of NDM-1 have been reported, NDM-6 (GenBank: JN967644.1) being the latest addition to the list.…”

Section: A Concise Update On Global Epidemiology (2009-2012)mentioning

confidence: 99%

A Region-specific Treatment Strategy To Address The Problem Of Drug Resistance By NDM-1-producing Pathogens

Ahmad¹,

Ashraf²

2013

Enz Eng

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New Delhi metallo-β-lactamase (NDM-1) is a serious threat to the existing antibiotic armory, and a potent weapon for bacteria to aid in in their 'battle'. It has the ability to inactivate all β-lactams, except aztreonam. However, most of the NDM-1-producers also produce aztreonam hydrolysing-β-lactamases, thereby making these pathogens absolutely resistant to all β-lactams. This minireview incorporates a concise update on global epidemiology (2009-2012) of NDM-1. However, the crux of the discussion is to focus on paucity of clinically useful therapeutic options, and suggest a solution to the drug resistance threat imposed by NDM-1 bacterial enzyme. The manuscript presents a 'region-specific treatment strategy' in a lucid flowchart format. The flowchart which lies at the interface of clinical microbiology and bioinformatics is expected to be useful in containing the problem of drug resistance due to NDM-1-producing bacterial pathogens.

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NDM-2 carbapenemase in Acinetobacter baumannii from Egypt

Abstract: This work further underlines the spread of NDM carbapenemases in A. baumannii, and the spread of the corresponding gene in the Middle East. It also describes the first variant of NDM-1.

Cited by 193 publications

References 9 publications

Genetic basis of antibiotic resistance in pathogenic Acinetobacter species

Genetic basis of antibiotic resistance in pathogenic Acinetobacter species

Prevalence of carbapenem resistance genes inAcinetobacter baumanniiisolated from clinical specimens obtained from an academic hospital in South Africa

A Region-specific Treatment Strategy To Address The Problem Of Drug Resistance By NDM-1-producing Pathogens

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