Nd4 Cost-Effectiveness of a Lidocaine Plaster Relative to Pregabalin Inthe Treatment of Post-Herpetic Neuralgia in Scotland

Dakin, H; Nuijten, Mjc; Nautrup, B Poulsen; Liedgens, Hiltrud

doi:10.1016/s1098-3015(10)64911-x

Cited by 3 publications

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“… 49 The scenario analysis using 1.03 LMPs per day showed LMP as dominant to gabapentin with a 99.8% confidence at a £20,000 per QALY threshold. The model relative to pregabalin showed LMP costs £674 per QALY relative to pregabalin 300 mg and £434 per QALY relative to pregabalin 600 mg. 50 The PSA demonstrated 99.9% confidence that LMP is cost-effective relative to 300 mg pregabalin and 99.8% confidence that it is cost-effective relative to 600 mg pregabalin at a £20,000 per QALY threshold. Modified TWIST analysis gave costs of £27 and £18 per additional month with sufficient pain relief and no intolerable side effects relative to pregabalin 300 mg and 600 mg, respectively.…”

Section: Resultsmentioning

confidence: 98%

Health economic evidence of 5% lidocaine medicated plaster in post-herpetic neuralgia

Liedgens

Obradović

Nuijten³

2013

CEOR

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BackgroundPost-herpetic neuralgia (PHN) is the most common and most debilitating complication of herpes zoster, and involves considerable associated costs.ObjectiveThis paper presents results from nine health economic studies undertaken in eight European countries that compared lidocaine medicated plaster with gabapentin and/or pregabalin in PHN. It aims to support the increasing need for published cost-effectiveness data for health care decision-making processes in Europe.MethodsAll studies were based on a similar core Markov model with data derived from clinical trials, local Delphi panels, and official national price and tariff lists. The main outcome measure was cost per quality-adjusted life year gained; time without pain or intolerable adverse events was also included as a secondary outcome measure. All studies focused on an elderly population of patients with PHN who had insufficient pain relief with standard analgesics and could not tolerate or had contraindications to tricyclic antidepressants.ResultsDespite considerable differences in many of the variables used, the results showed remarkable similarity and suggested that use of lidocaine medicated plaster offered cost-savings in many of the countries studied, where it proved a highly cost-effective alternative to both gabapentin and pregabalin.ConclusionLidocaine medicated plaster is a cost-effective alternative to gabapentin and pregabalin in the treatment of PHN. These savings are largely the result of the superior safety profile of the lidocaine medicated plaster.

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Section: Resultsmentioning

confidence: 98%