Nd:yag Laser Resection Can Improve Symptom Control, Progression Free Period and Survival in Selected Lung Cancer Patients

Zarić, Bojan; C̆anak, V.; Milovančev, Aleksandra; Šarčev, Tatjana; Jovanović, Svetlana; Budisin, Evica; Nišević, V.

doi:10.1378/chest.132.4_meetingabstracts.517b

Cited by 4 publications

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“…As part of a multimodality treatment of advanced lung cancer, HDR-EBBT may influence survival in patients with malignant central airway obstruction [5]. HDR-EBBT has been used alone and with EBRT or interventional pulmonology in various palliative protocols [6][7][8]. Minimally invasive therapies have attained increasing attention for the treatment of cancer patients.…”

Section: Introductionmentioning

confidence: 99%

CT-guided interstitial brachytherapy of inoperable non-small cell lung cancer

Wang

Liu

et al. 2011

Lung Cancer

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Section: Introductionmentioning

confidence: 99%

CT-guided interstitial brachytherapy of inoperable non-small cell lung cancer

Wang

Liu

et al. 2011

Lung Cancer

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“…In the latter study, Zarić et al . (2007a,b) evaluated effects of Nd : YAG laser resection on symptoms, signs and ECOG performance status in lung cancer patients. Once again, the technique showed efficacy in palliation of symptoms and signs leading to improvement in performance status, progression free survival and survival of lung cancer patients.…”

Section: Discussionmentioning

confidence: 99%

Neodymium yttrium-aluminium-garnet laser resection significantly improves quality of life in patients with malignant central airway obstruction due to lung cancer

et al. 2014

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Neodymium yttrium-aluminium-garnet (Nd : YAG) laser resection is one of the mostly used interventional pulmonology techniques for urgent desobstruction of malignant central airway obstruction (CAO). The major aim of this trial was to evaluate potential influence of Nd : YAG laser resection on overall quality of life (QoL) in patients with central lung cancer. Patients with malignant CAO scheduled for Nd : YAG laser resection were prospectively recruited in the trial. All patients were given European Organization for Research and Treatment, Quality of Life questionnaire (EORTC QLQ-30 v.3) before the procedure and approximately 2 weeks after the treatment. There were 37 male and 10 female patients, average age 54 ± 10 years. Most common tumour type was adenocarcinoma diagnosed in 51% of patients. Majority of patients were diagnosed in stage IIIB (53.2%) and stage IV (25.5%). Most common Eastern Cooperative Oncology Group performance status was 1 (72.3%). Nd : YAG laser resection significantly improved (P<0.0001) QoL and overall health according to EORTC QLQ-30. However, in some of the questions dealing with nausea, vomiting, diarrhoea, constipation, family life, social activities and financial situation, we did not observe statistically significant improvement. Nd : YAG laser resection of malignant CAO significantly improves QoL and overall health in patients with lung cancer.

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“…In two of our previous papers that evaluated efficacy of Nd:YAG laser resection in treatment of lung cancer, the overall complication rate was under 5%, even though we did not analyze complications in the mentioned paper and the number of patients was significantly lower than in this study. [3233] There are studies, but with low number of patients, which show the absence of complications after laser resection of centrally located advanced stage lung cancer. [34]…”

Section: Discussionmentioning

confidence: 99%

Patient-related independent clinical risk factors for early complications following Nd: YAG laser resection of lung cancer

et al. 2012

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INTRODUCTION:Neodymium:yttrium aluminum garnet (Nd:YAG) laser resection is one of the most established interventional pulmonology techniques for immediate debulking of malignant central airway obstruction (CAO). The major aim of this study was to investigate the complication rate and identify clinical risk factors for complications in patients with advanced lung cancer.METHODS:In the period from January 2006 to January 2011, data sufficient for analysis were identified in 464 patients. Nd:YAG laser resection due to malignant CAO was performed in all patients. The procedure was carried out in general anesthesia. Complications after laser resection were defined as severe hypoxemia, global respiratory failure, arrhythmia requiring treatment, hemoptysis, pneumothorax, pneumomediastinum, pulmonary edema, tracheoesophageal fistulae, and death. Risk factors were defined as acute myocardial infarction within 6 months before treatment, hypertension, chronic arrhythmia, chronic obstructive pulmonary disease (COPD), stabilized cardiomyopathy, previous external beam radiotherapy, previous chemotherapy, and previous interventional pulmonology treatment.RESULTS:There was 76.1% male and 23.9% female patients in the study, 76.5% were current smokers, 17.2% former smokers, and 6.3% of nonsmokers. The majority of patients had squamous cell lung cancer (70%), small cell lung cancer was identified in 18.3%, adenocarcinoma in 3.4%, and metastases from lung primary in 8.2%. The overall complication rate was 8.4%. Statistically significant risk factors were age (P = 0.001), current smoking status (P = 0.012), arterial hypertension (P < 0.0001), chronic arrhythmia (P = 0.034), COPD (P < 0.0001), and stabilized cardiomyopathy (P < 0.0001). Independent clinical risk factors were age over 60 years (P = 0.026), arterial hypertension (P < 0.0001), and COPD (P < 0.0001).CONCLUSION:Closer monitoring of patients with identified risk factors is advisable prior and immediately after laser resection. In order to avoid or minimize complications, special attention should be directed toward patients who are current smokers, over 60 years of age, with arterial hypertension or COPD.

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Nd:yag Laser Resection Can Improve Symptom Control, Progression Free Period and Survival in Selected Lung Cancer Patients

Cited by 4 publications

References 0 publications

CT-guided interstitial brachytherapy of inoperable non-small cell lung cancer

CT-guided interstitial brachytherapy of inoperable non-small cell lung cancer

Neodymium yttrium-aluminium-garnet laser resection significantly improves quality of life in patients with malignant central airway obstruction due to lung cancer

Patient-related independent clinical risk factors for early complications following Nd: YAG laser resection of lung cancer

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