Nd-doped Calcium Silicate: Photothermal Effect, Fluorescence Performance, and Biological Properties of Its Composite Electrospun Membrane

Abstract

Biomaterials with photothermal effect and tissue repair activity have potential applications in the field of regenerative medicine. Considering the dual functions of fluorescence and photothermal effect of rare earth element Nd, and the excellent tissue repair biological activity of calcium-silicon (Ca-Si) based materials, here Nd-Ca-Si-based bioceramics (Nd/CS) powder we prepared by introducing Nd into calcium silicate through co-precipitation method and sintering at temperatures above 800 ℃, and evaluated phase composition, photothermal, and fluorescence properties of the powder. We further prepared a ceramic powder/polymer composite electrospun membrane, and evaluated its physical, chemical and biological properties. The results showed that Nd/CS ceramic powder and composite membrane not only had excellent photothermal performance and fluorescence emitting effects, but also showed fluorescence thermometry property. Preliminary cell experiments confirmed that the composite membrane was bioactive to stimulate fibroblast activity. This Nd-Ca-Si-based bioceramic and its composite material with integrated photothermal, fluorescence imaging/fluorescence thermometry properties and bioactivity, may have 第 9 期 马玲玲, 等: Nd 掺杂硅酸钙及其复合电纺丝膜的制备及性能研究 975 potential applications in regenerative medicine.