ncRNAs and their impact on dopaminergic neurons: Autophagy pathways in Parkinson's disease

Thapa, Riya; Moglad, Ehssan; Afzal, Muhammad; Gupta, Gaurav; Bhat, Asif Ahmad; almalki, Waleed Hassan; Kazmi, Imran; Alzarea, Sami I.; Pant, Kumud; Ali, Haider; Paudel, Keshav Raj; Dureja, Harish; Singh, Thakur Gurjeet; Singh, Sachin Kumar; Dua, Kamal

doi:10.1016/j.arr.2024.102327

Ageing Research Reviews

2024

DOI: 10.1016/j.arr.2024.102327

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ncRNAs and their impact on dopaminergic neurons: Autophagy pathways in Parkinson's disease

Riya Thapa,

Ehssan Moglad,

Muhammad Afzal

et al.

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2024

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Cited by 3 publications

References 205 publications

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lncRNAs as prognostic markers and therapeutic targets in cuproptosis-mediated cancer

Bhat,

Afzal,

Moglad

et al. 2024

Clin Exp Med

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Long non-coding RNAs (lncRNAs) have emerged as crucial regulators in various cellular processes, including cancer progression and stress response. Recent studies have demonstrated that copper accumulation induces a unique form of cell death known as cuproptosis, with lncRNAs playing a key role in regulating cuproptosis-associated pathways. These lncRNAs may trigger cell-specific responses to copper stress, presenting new opportunities as prognostic markers and therapeutic targets. This paper delves into the role of lncRNAs in cuproptosis-mediated cancer, underscoring their potential as biomarkers and targets for innovative therapeutic strategies. A thorough review of scientific literature was conducted, utilizing databases such as PubMed, Google Scholar, and ScienceDirect, with search terms like 'lncRNAs,' 'cuproptosis,' and 'cancer.' Studies were selected based on their relevance to lncRNA regulation of cuproptosis pathways and their implications for cancer prognosis and treatment. The review highlights the significant contribution of lncRNAs in regulating cuproptosis-related genes and pathways, impacting copper metabolism, mitochondrial stress responses, and apoptotic signaling. Specific lncRNAs are potential prognostic markers in breast, lung, liver, ovarian, pancreatic, and gastric cancers. The objective of this article is to explore the role of lncRNAs as potential prognostic markers and therapeutic targets in cancers mediated by cuproptosis.

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lncRNAs as prognostic markers and therapeutic targets in cuproptosis-mediated cancer

Bhat,

Afzal,

Moglad

et al. 2024

Clin Exp Med

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From diagnosis to therapy: The critical role of lncRNAs in hepatoblastoma

Alzahrani,

Khan,

Singla

et al. 2024

Pathology - Research and Practice

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Therapeutic Approaches to Microglial Dysfunction in Alzheimer's Disease: Enhancing Phagocytosis and Metabolic Regulation

Almalki,

Almujri

2024

Pathology - Research and Practice

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ncRNAs and their impact on dopaminergic neurons: Autophagy pathways in Parkinson's disease

Cited by 3 publications

References 205 publications

lncRNAs as prognostic markers and therapeutic targets in cuproptosis-mediated cancer

lncRNAs as prognostic markers and therapeutic targets in cuproptosis-mediated cancer

From diagnosis to therapy: The critical role of lncRNAs in hepatoblastoma

Therapeutic Approaches to Microglial Dysfunction in Alzheimer's Disease: Enhancing Phagocytosis and Metabolic Regulation

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