(1) Background: A disabled student or employee in a certain university faces a large number of obstacles in achieving his/her ordinary duties. An interactive smart search and communication application can support the people at the university campus and Science Park in a number of ways. Primarily, it can strengthen their professional network and establish a responsive eco-system. Therefore, the objective of this research work is to design and implement a unified flexible and adaptable interface. This interface supports an intensive search and communication tool across the university. It would benefit everybody on campus, especially the People with Disabilities (PWDs).(2) Methods: In this project, three main contributions are presented: (A) Assistive Technology (AT) software design and implementation (based on user-and technology-centered design); (B) A wireless sensor network employed to track and determine user's location; and (C) A novel event behavior algorithm and movement direction algorithm used to monitor and predict users' behavior and intervene with them and their caregivers when required. (3) Results: This work has developed a comprehensive and universal application with a unified, flexible, and adaptable interface to support the different conditions of PWDs. It has employed an interactive smart based-location service for establishing a smart university Geographic Information System (GIS) solution. This GIS solution has been based on tracking location service, mobility, and wireless sensor network technologies. (4) Conclusion: The proposed system empowered inter-disciplinary interaction between management, staff, researchers, and students, including the PWDs. Identifying the needs of the PWDs has led to the determination of the relevant requirements for designing and implementing a unified flexible and adaptable interface suitable for PWDs on the university campus.