Navigating surgical fluorescence cameras using near-infrared optical tracking

Oosterom, Matthias N. van; Houting, David A. den; Velde, Cornelis J.H. van de; Leeuwen, Fijs W. B. van

doi:10.1117/1.jbo.23.5.056003

Cited by 7 publications

(8 citation statements)

References 25 publications

(39 reference statements)

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“…Optical technologies such as fluorescence imaging does not require direct contact with tissue for a light source to excite fluorophore molecules and a detector to collect the light that is subsequently emitted [ 136 ]. Since light sources including ambient light [ 137 ], plenum light [ 138 ] and light emitted by optical tracking systems [ 139 ] can interfere with signal detection, fluorescence applications often require dimming of interfering light sources such as the operating room (OR) lights. Radioguidance modalities are purely designed to detect radiopharmaceuticals that intrinsically generate a signal (i.e., gamma rays or beta particles).…”

Section: Resultsmentioning

confidence: 99%

The current status and future prospects for molecular imaging-guided precision surgery

et al. 2022

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Molecular imaging technologies are increasingly used to diagnose, monitor, and guide treatment of i.e., cancer. In this review, the current status and future prospects of the use of molecular imaging as an instrument to help realize precision surgery is addressed with focus on the main components that form the conceptual basis of intraoperative molecular imaging. Paramount for successful interventions is the relevance and accessibility of surgical targets. In addition, selection of the correct combination of imaging agents and modalities is critical to visualize both microscopic and bulk disease sites with high affinity and specificity. In this context developments within engineering/imaging physics continue to drive the growth of image-guided surgery. Particularly important herein is enhancement of sensitivity through improved contrast and spatial resolution, features that are critical if sites of cancer involvement are not to be overlooked during surgery. By facilitating the connection between surgical planning and surgical execution, digital surgery technologies such as computer-aided visualization nicely complement these technologies. The complexity of image guidance, combined with the plurality of technologies that are becoming available, also drives the need for evaluation mechanisms that can objectively score the impact that technologies exert on the performance of healthcare professionals and outcome improvement for patients.

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Section: Resultsmentioning

confidence: 99%

The current status and future prospects for molecular imaging-guided precision surgery

et al. 2022

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“…To evaluate the sufficient fluorescent SBR needed for robotic surgery, we created a custom silicone (4 × 7) grid-phantom setup (Dragon Skin FXPro silicone, mixed with coloring pigment, FormX, Amsterdam, the Netherlands) that contained 28 possible target locations that could be sealed off with silicone lids. As targets we used 33.33 µL fluorescent beads [ 37 ], containing different concentrations of ICG (1–0.0625 mg/mL dissolved in methanol) incorporated in epoxy resin (ratio: 1:6:1 for epoxy resin, epoxy hardener and ICG solution, respectively).…”

Section: Methodsmentioning

confidence: 99%

Quantifying the Impact of Signal-to-background Ratios on Surgical Discrimination of Fluorescent Lesions

et al. 2022

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Purpose Surgical fluorescence guidance has gained popularity in various settings, e.g., minimally invasive robot-assisted laparoscopic surgery. In pursuit of novel receptor-targeted tracers, the field of fluorescence-guided surgery is currently moving toward increasingly lower signal intensities. This highlights the importance of understanding the impact of low fluorescence intensities on clinical decision making. This study uses kinematics to investigate the impact of signal-to-background ratios (SBR) on surgical performance. Methods Using a custom grid exercise containing hidden fluorescent targets, a da Vinci Xi robot with Firefly fluorescence endoscope and ProGrasp and Maryland forceps instruments, we studied how the participants’ (N = 16) actions were influenced by the fluorescent SBR. To monitor the surgeon’s actions, the surgical instrument tip was tracked using a custom video-based tracking framework. The digitized instrument tracks were then subjected to multi-parametric kinematic analysis, allowing for the isolation of various metrics (e.g., velocity, jerkiness, tortuosity). These were incorporated in scores for dexterity (Dx), decision making (DM), overall performance (PS) and proficiency. All were related to the SBR values. Results Multi-parametric analysis showed that task completion time, time spent in fluorescence-imaging mode and total pathlength are metrics that are directly related to the SBR. Below SBR 1.5, these values substantially increased, and handling errors became more frequent. The difference in Dx and DM between the targets that gave SBR < 1.50 and SBR > 1.50, indicates that the latter group generally yields a 2.5-fold higher Dx value and a threefold higher DM value. As these values provide the basis for the PS score, proficiency could only be achieved at SBR > 1.55. Conclusion By tracking the surgical instruments we were able to, for the first time, quantitatively and objectively assess how the instrument positioning is impacted by fluorescent SBR. Our findings suggest that in ideal situations a minimum SBR of 1.5 is required to discriminate fluorescent lesions, a substantially lower value than the SBR 2 often reported in literature.

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“…Dental implants are a predictable treatment option for treating both partially and totally edentulous patients [ 1 ]. However, some complications may occur, causing implant failures.…”

Section: Introductionmentioning

confidence: 99%

Dental Implant Navigation System Based on Trinocular Stereo Vision

Wang

Zou

et al. 2022

Sensors

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Traditional dental implant navigation systems (DINS) based on binocular stereo vision (BSV) have limitations, for example, weak anti-occlusion abilities, as well as problems with feature point mismatching. These shortcomings limit the operators’ operation scope, and the instruments may even cause damage to the adjacent important blood vessels, nerves, and other anatomical structures. Trinocular stereo vision (TSV) is introduced to DINS to improve the accuracy and safety of dental implants in this study. High positioning accuracy is provided by adding cameras. When one of the cameras is blocked, spatial positioning can still be achieved, and doctors can adjust to system tips; thus, the continuity and safety of the surgery is significantly improved. Some key technologies of DINS have also been updated. A bipolar line constraint algorithm based on TSV is proposed to eliminate the feature point mismatching problem. A reference template with active optical markers attached to the jaw measures head movement. A T-type template with active optical markers is used to obtain the position and direction of surgery instruments. The calibration algorithms of endpoint, axis, and drill are proposed for 3D display of the surgical instrument in real time. With the preoperative path planning of implant navigation software, implant surgery can be carried out. Phantom experiments are carried out based on the system to assess the feasibility and accuracy. The results show that the mean entry deviation, exit deviation, and angle deviation are 0.55 mm, 0.88 mm, and 2.23 degrees, respectively.

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Navigating surgical fluorescence cameras using near-infrared optical tracking

Cited by 7 publications

References 25 publications

The current status and future prospects for molecular imaging-guided precision surgery

The current status and future prospects for molecular imaging-guided precision surgery

Quantifying the Impact of Signal-to-background Ratios on Surgical Discrimination of Fluorescent Lesions

Dental Implant Navigation System Based on Trinocular Stereo Vision

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