Navigating practical challenges in immunotherapy for metastatic triple negative breast cancer

Licata, Luca; Dieci, Maria Vittoria; De Angelis, Carmine; Marchiò, Caterina; Miglietta, Federica; Cortesi, Laura; Fabi, Alessandra; Schmid, Peter; Cortes, Javier; Pusztai, Lajos; Bianchini, Giampaolo; Curigliano, Giuseppe

doi:10.1016/j.ctrv.2024.102762

Cited by 1 publication

(1 citation statement)

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“…The introduction of immunotherapy has revolutionized the therapeutic strategies of numerous cancer types ( 9 ). Notable clinical outcomes have been achieved with cancer vaccines, adoptive T cell therapies, and antibodies that enhance T lymphocyte function ( 10 ). Furthermore, there is growing evidence that adaptive immunity plays a significant role in the enduring clinical benefits of traditional anticancer treatments like chemotherapy and radiotherapy ( 11 , 12 ).…”

Section: Introductionmentioning

confidence: 99%

Neoantigens in cancer immunotherapy: focusing on alternative splicing

Huang,

Wen,

Tuerhong

et al. 2024

Front. Immunol.

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Alternative splicing (AS) functions as a crucial program in transcriptional modulation, leading to proteomic diversity and functional alterations of proteins. These splicing actions induce various neoantigens that hold prognostic significance and contribute to various aspects of cancer progression, including immune responses against cancer. The advent of immunotherapy has remarkably revolutionized tumor therapy. In this regard, AS-derived neoantigens are potent targets for cancer vaccines and chimeric antigen receptor (CAR) T cell therapies. In this review, we outline that AS-derived neoantigens serve as promising immunotherapeutic targets and guide immunotherapy strategies. This evidence contributes to a deeper comprehension of the complexity of proteomic diversity and provides novel perspectives and techniques for precision medicine in immunotherapy. Moreover, we underscore the obstacles that are awaited to be addressed for this novel approach to become clinically applicable.

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